Multicenter Comparison of Contrast-Enhanced FDG PET/CT and 64-Slice Multi-Detector-Row CT for Initial Staging and Response Evaluation at the End of Treatment in Patients with Lymphoma
Objectives To compare staging correctness between contrast-enhanced FDG PET/ceCT and 64-slice multi-detector-row CT (ceCT64) for initial staging and response evaluation at the end of treatment (EOT) in patients with Hodgkin lymphoma, diffuse large B cell lymphoma (DLBCL), and follicular lymphoma. Me...
| Autores: | , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/717167 |
| Acceso en línea: | http://hdl.handle.net/10486/717167 https://dx.doi.org/10.1097/RLU.0000000000001718 |
| Access Level: | acceso abierto |
| Palabra clave: | CT FDG PET/CT Hodgkin lymphoma lymphoma non-Hodgkin lymphoma Medicina |
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Multicenter Comparison of Contrast-Enhanced FDG PET/CT and 64-Slice Multi-Detector-Row CT for Initial Staging and Response Evaluation at the End of Treatment in Patients with LymphomaGómez León, M. de las NievesDelgado Bolton, Roberto C.Campo del Val, María Lourdes delCabezas, BeatrizArranz Sáez, María ReyesGarcía, MartaCannata, JimenaGonzález Ortega, SaturninoPérez Sáez, Ángeles M.López-Botet Zulueta, BegoñaRodríguez Vigil, BeatrizMateo, MartaColletti, Patrick M.Rubello, DomenicoCarreras, José L.CTFDG PET/CTHodgkin lymphomalymphomanon-Hodgkin lymphomaMedicinaObjectives To compare staging correctness between contrast-enhanced FDG PET/ceCT and 64-slice multi-detector-row CT (ceCT64) for initial staging and response evaluation at the end of treatment (EOT) in patients with Hodgkin lymphoma, diffuse large B cell lymphoma (DLBCL), and follicular lymphoma. Methods This prospective study compared initial staging and response evaluation at EOT. One hundred eighty-one patients were randomly assigned to either ceCT64 or FDG PET/ceCT. A nuclear medicine physician and a radiologist read FDG PET/ceCT scans independently and achieved post hoc consensus, whereas another independent radiologist interpreted ceCT64 separately. The reference standard included all clinical information, all tests, and follow-up. Ethics committees of the participating centers approved the study, and all participants provided written consent. Results Ninety-one patients were randomized to ceCT64 and 90 to FDG PET/ceCT; 72 had Hodgkin lymphoma, 72 had DLBCL, and 37 had follicular lymphoma. There was excellent correlation between the reference standard and initial staging for both FDG PET/ceCT (κ = 0.96) and ceCT64 (κ = 0.84), although evaluation of the response at EOT was excellent only for FDG PET/ceCT (κ = 0.91). Conclusions Our study demonstrated satisfactory agreement between FDG PET/ceCT (κ = 0.96) and ceCT64 (κ = 0.84) in initial staging compared with the reference standard (P = 0.16). Response evaluation at EOT with FDG PET/ceCT (κ = 0.91) was superior compared with ceCT64 (κ = 0.307) (P < 0.001)This work was financially supported by the Spanish Health Ministry through the Fondo de Investigaciones Sanitarias (F.I.S.) of the Instituto de Salud Carlos III, Madrid (file no. 11/01800) granted in 2011. The final report was presented in 2016Lippincott, Williams & WilkinsDepartamento de MedicinaFacultad de Medicina20172017-08-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/717167https://dx.doi.org/10.1097/RLU.0000000000001718reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7171672026-06-23T12:46:27Z |
| dc.title.none.fl_str_mv |
Multicenter Comparison of Contrast-Enhanced FDG PET/CT and 64-Slice Multi-Detector-Row CT for Initial Staging and Response Evaluation at the End of Treatment in Patients with Lymphoma |
| title |
Multicenter Comparison of Contrast-Enhanced FDG PET/CT and 64-Slice Multi-Detector-Row CT for Initial Staging and Response Evaluation at the End of Treatment in Patients with Lymphoma |
| spellingShingle |
Multicenter Comparison of Contrast-Enhanced FDG PET/CT and 64-Slice Multi-Detector-Row CT for Initial Staging and Response Evaluation at the End of Treatment in Patients with Lymphoma Gómez León, M. de las Nieves CT FDG PET/CT Hodgkin lymphoma lymphoma non-Hodgkin lymphoma Medicina |
| title_short |
Multicenter Comparison of Contrast-Enhanced FDG PET/CT and 64-Slice Multi-Detector-Row CT for Initial Staging and Response Evaluation at the End of Treatment in Patients with Lymphoma |
| title_full |
Multicenter Comparison of Contrast-Enhanced FDG PET/CT and 64-Slice Multi-Detector-Row CT for Initial Staging and Response Evaluation at the End of Treatment in Patients with Lymphoma |
| title_fullStr |
Multicenter Comparison of Contrast-Enhanced FDG PET/CT and 64-Slice Multi-Detector-Row CT for Initial Staging and Response Evaluation at the End of Treatment in Patients with Lymphoma |
| title_full_unstemmed |
Multicenter Comparison of Contrast-Enhanced FDG PET/CT and 64-Slice Multi-Detector-Row CT for Initial Staging and Response Evaluation at the End of Treatment in Patients with Lymphoma |
| title_sort |
Multicenter Comparison of Contrast-Enhanced FDG PET/CT and 64-Slice Multi-Detector-Row CT for Initial Staging and Response Evaluation at the End of Treatment in Patients with Lymphoma |
| dc.creator.none.fl_str_mv |
Gómez León, M. de las Nieves Delgado Bolton, Roberto C. Campo del Val, María Lourdes del Cabezas, Beatriz Arranz Sáez, María Reyes García, Marta Cannata, Jimena González Ortega, Saturnino Pérez Sáez, Ángeles M. López-Botet Zulueta, Begoña Rodríguez Vigil, Beatriz Mateo, Marta Colletti, Patrick M. Rubello, Domenico Carreras, José L. |
| author |
Gómez León, M. de las Nieves |
| author_facet |
Gómez León, M. de las Nieves Delgado Bolton, Roberto C. Campo del Val, María Lourdes del Cabezas, Beatriz Arranz Sáez, María Reyes García, Marta Cannata, Jimena González Ortega, Saturnino Pérez Sáez, Ángeles M. López-Botet Zulueta, Begoña Rodríguez Vigil, Beatriz Mateo, Marta Colletti, Patrick M. Rubello, Domenico Carreras, José L. |
| author_role |
author |
| author2 |
Delgado Bolton, Roberto C. Campo del Val, María Lourdes del Cabezas, Beatriz Arranz Sáez, María Reyes García, Marta Cannata, Jimena González Ortega, Saturnino Pérez Sáez, Ángeles M. López-Botet Zulueta, Begoña Rodríguez Vigil, Beatriz Mateo, Marta Colletti, Patrick M. Rubello, Domenico Carreras, José L. |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Medicina Facultad de Medicina |
| dc.subject.none.fl_str_mv |
CT FDG PET/CT Hodgkin lymphoma lymphoma non-Hodgkin lymphoma Medicina |
| topic |
CT FDG PET/CT Hodgkin lymphoma lymphoma non-Hodgkin lymphoma Medicina |
| description |
Objectives To compare staging correctness between contrast-enhanced FDG PET/ceCT and 64-slice multi-detector-row CT (ceCT64) for initial staging and response evaluation at the end of treatment (EOT) in patients with Hodgkin lymphoma, diffuse large B cell lymphoma (DLBCL), and follicular lymphoma. Methods This prospective study compared initial staging and response evaluation at EOT. One hundred eighty-one patients were randomly assigned to either ceCT64 or FDG PET/ceCT. A nuclear medicine physician and a radiologist read FDG PET/ceCT scans independently and achieved post hoc consensus, whereas another independent radiologist interpreted ceCT64 separately. The reference standard included all clinical information, all tests, and follow-up. Ethics committees of the participating centers approved the study, and all participants provided written consent. Results Ninety-one patients were randomized to ceCT64 and 90 to FDG PET/ceCT; 72 had Hodgkin lymphoma, 72 had DLBCL, and 37 had follicular lymphoma. There was excellent correlation between the reference standard and initial staging for both FDG PET/ceCT (κ = 0.96) and ceCT64 (κ = 0.84), although evaluation of the response at EOT was excellent only for FDG PET/ceCT (κ = 0.91). Conclusions Our study demonstrated satisfactory agreement between FDG PET/ceCT (κ = 0.96) and ceCT64 (κ = 0.84) in initial staging compared with the reference standard (P = 0.16). Response evaluation at EOT with FDG PET/ceCT (κ = 0.91) was superior compared with ceCT64 (κ = 0.307) (P < 0.001) |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2017-08-01 |
| dc.type.none.fl_str_mv |
research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10486/717167 https://dx.doi.org/10.1097/RLU.0000000000001718 |
| url |
http://hdl.handle.net/10486/717167 https://dx.doi.org/10.1097/RLU.0000000000001718 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Lippincott, Williams & Wilkins |
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Lippincott, Williams & Wilkins |
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reponame:Biblos-e Archivo. Repositorio Institucional de la UAM instname:Universidad Autónoma de Madrid |
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Universidad Autónoma de Madrid |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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Biblos-e Archivo. Repositorio Institucional de la UAM |
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