Characterization of Vaginal Escherichia coli Isolated from Pregnant Women in Two Different African Sites

The relevance of vaginal colonization of pregnant women by Escherichia coli is poorly understood, despite these strains sharing a similar virulence profile with other extraintestinal pathogenic E. coli producing severe obstetric and neonatal infections. We characterized the epidemiology, antimicrobi...

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Detalles Bibliográficos
Autores: Sáez-López, Emma, Cossa, Anelsio, Benmessaoud, Rachid, Madrid, Lola, Moraleda Redecilla, Cinta, Villanueva, Sonia, Tligui, Houssain, Moiane, Benilde, Alami, Hassan, Massora, Sérgio, Bezad, Rachid, Mandomando, Inácio, Bosch Mestres, Jordi, Vila Estapé, Jordi, Bassat Orellana, Quique, Soto González, Sara M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/101551
Acceso en línea:https://hdl.handle.net/2445/101551
Access Level:acceso abierto
Palabra clave:Escheríchia coli
Embarassades
Resistència als medicaments
Septicèmia
Neonatologia
Epidemiologia
Escherichia coli
Pregnant women
Drug resistance
Septicemia
Neonatology
Epidemiology
Descripción
Sumario:The relevance of vaginal colonization of pregnant women by Escherichia coli is poorly understood, despite these strains sharing a similar virulence profile with other extraintestinal pathogenic E. coli producing severe obstetric and neonatal infections. We characterized the epidemiology, antimicrobial susceptibility and virulence profiles of 84 vaginal E. coli isolates from pregnant women from Rabat (Morocco) and Manhica (Mozambique), two very distinct epidemiological settings. Low levels of antimicrobial resistance were observed to all drugs tested, except for trimethoprim-sulfamethoxazole in Manhica, where this drug is extensively used as prophylaxis for opportunistic HIV infections. The most prevalent virulence factors were related to iron acquisition systems. Phylogroup A was the most common in Rabat, while phylogroups E and non-typeable were the most frequent in Manhica. Regardless of the apparently "low virulence" of these isolates, the frequency of infections is higher and the outcomes more devastating in constrained-resources conditions, especially among pregnant women and newborns.

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