Influence of shape and gradient refractive index in the accommodative changes of spherical aberration in nonhuman primate crystalline lenses

11 pags., 8 figs.

Detalles Bibliográficos
Autores: Castro, Alberto de, Birkenfeld, Judith S., Maceo, B. M., Manns, Fabrice, Arrieta, Esdras, Parel, Jean Marie, Marcos, Susana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/252454
Acceso en línea:http://hdl.handle.net/10261/252454
Access Level:acceso abierto
Palabra clave:Crystalline lens
Gradient refractive index
Spherical aberration
Accommodation
GRIN
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spelling Influence of shape and gradient refractive index in the accommodative changes of spherical aberration in nonhuman primate crystalline lensesCastro, Alberto deBirkenfeld, Judith S.Maceo, B. M.Manns, FabriceArrieta, EsdrasParel, Jean MarieMarcos, SusanaCrystalline lensGradient refractive indexSpherical aberrationAccommodationGRIN11 pags., 8 figs.Purpose. To estimate changes in surface shape and gradient refractive index (GRIN) profile in primate lenses as a function of accommodation. To quantify the contribution of surface shape and GRIN to spherical aberration changes with accommodation. Methods. Crystalline lenses from 15 cynomolgus monkeys were studied in vitro under different levels of accommodation produced by a stretching system. Lens shape was obtained from optical coherence tomography (OCT) cross-sectional images. The GRIN was reconstructed with a search algorithm using the optical path measured from OCT images and the measured back focal length. The spherical aberration of the lens was estimated as a function of accommodation using the reconstructed GRIN and a homogeneous refractive index. Results. The lens anterior and posterior radii of curvature decreased with increasing lens power. Both surfaces exhibited negative asphericities in the unaccommodated state. The anterior surface conic constant shifted toward less negative values with accommodation, while the value of the posterior remained constant. GRIN parameters remained constant with accommodation. The lens spherical aberration with GRIN distribution was negative and higher in magnitude than that with a homogeneous equivalent refractive index (by 29% and 53% in the unaccommodated and fully accommodated states, respectively). Spherical aberration with the equivalent refractive index shifted with accommodation toward negative values (-0.070 lm/diopter [D]), but the reconstructed GRIN shifted it farther (-0.124 lm/ D). Conclusions. When compared with the lens with the homogeneous equivalent refractive index, the reconstructed GRIN lens has more negative spherical aberration and a larger shift toward more negative values with accommodation. © 2013 The Association for Research in Vision and Ophthalmology, Inc.Supported by a Spanish government Grant FIS2011-25637 and the European Research Council ERC-AdG-294099 (SM); CSIC JAE-Pre Program fellowship (JB); CSIC i-LINKþ 2012, iLINKþ0609 (SM, J-MP); National Eye Institute Grants 2R01EY14225, 1R01EY021834, 1F31EY021444 (NSRA Individual Predoctoral Fellowship [BM]), P30EY14801 (Center Grant); the Florida Lions Eye Bank; the Henri and Flore Lesieur Foundation (J-MP); Research to Prevent Blindness; the Vision Cooperative Research Centre, Sydney, New South Wales, Australia; and the Australian Federal Government through the Cooperative Research Centres ProgrammeAssociation for Research in Vision and OphthalmologyMinisterio de Educación y Ciencia (España)European CommissionConsejo Superior de Investigaciones Científicas (España)National Eye Institute (US)Florida Lions Eye BankHenri and Flore Lesieur FoundationVision Cooperative Research Centre (Australia)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120132021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/252454reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#MEC/FIS2011-25637info:eu-repo/grantAgreement/EC/FP7/294099http://dx.doi.org/10.1167/iovs.13-11996Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2524542026-05-22T06:33:51Z
dc.title.none.fl_str_mv Influence of shape and gradient refractive index in the accommodative changes of spherical aberration in nonhuman primate crystalline lenses
title Influence of shape and gradient refractive index in the accommodative changes of spherical aberration in nonhuman primate crystalline lenses
spellingShingle Influence of shape and gradient refractive index in the accommodative changes of spherical aberration in nonhuman primate crystalline lenses
Castro, Alberto de
Crystalline lens
Gradient refractive index
Spherical aberration
Accommodation
GRIN
title_short Influence of shape and gradient refractive index in the accommodative changes of spherical aberration in nonhuman primate crystalline lenses
title_full Influence of shape and gradient refractive index in the accommodative changes of spherical aberration in nonhuman primate crystalline lenses
title_fullStr Influence of shape and gradient refractive index in the accommodative changes of spherical aberration in nonhuman primate crystalline lenses
title_full_unstemmed Influence of shape and gradient refractive index in the accommodative changes of spherical aberration in nonhuman primate crystalline lenses
title_sort Influence of shape and gradient refractive index in the accommodative changes of spherical aberration in nonhuman primate crystalline lenses
dc.creator.none.fl_str_mv Castro, Alberto de
Birkenfeld, Judith S.
Maceo, B. M.
Manns, Fabrice
Arrieta, Esdras
Parel, Jean Marie
Marcos, Susana
author Castro, Alberto de
author_facet Castro, Alberto de
Birkenfeld, Judith S.
Maceo, B. M.
Manns, Fabrice
Arrieta, Esdras
Parel, Jean Marie
Marcos, Susana
author_role author
author2 Birkenfeld, Judith S.
Maceo, B. M.
Manns, Fabrice
Arrieta, Esdras
Parel, Jean Marie
Marcos, Susana
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Educación y Ciencia (España)
European Commission
Consejo Superior de Investigaciones Científicas (España)
National Eye Institute (US)
Florida Lions Eye Bank
Henri and Flore Lesieur Foundation
Vision Cooperative Research Centre (Australia)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Crystalline lens
Gradient refractive index
Spherical aberration
Accommodation
GRIN
topic Crystalline lens
Gradient refractive index
Spherical aberration
Accommodation
GRIN
description 11 pags., 8 figs.
publishDate 2013
dc.date.none.fl_str_mv 2013
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/252454
url http://hdl.handle.net/10261/252454
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
MEC/FIS2011-25637
info:eu-repo/grantAgreement/EC/FP7/294099
http://dx.doi.org/10.1167/iovs.13-11996
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Association for Research in Vision and Ophthalmology
publisher.none.fl_str_mv Association for Research in Vision and Ophthalmology
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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