Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis

All rights reserved. Visceral leishmaniasis (VL) is one of the most important tropical diseases worldwide. Although chemotherapy has been widely used to treat this disease, problems related to the development of parasite resistance and side effects associated with the compounds used have been noted....

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Autores: Duarte, Mariana Costa, Lage, Daniela Pagliara, Martins, Vívian Tamietti, Chávez-Fumagalli, Miguel Angel, Roatt, Bruno Mendes, Menezes-Souza, Daniel, Goulart, Luiz Ricardo, Soto Álvarez, Manuel, Tavares, Carlos Alberto Pereira, Coelho, Eduardo Antonio Ferraz
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/690883
Acceso en línea:http://hdl.handle.net/10486/690883
https://dx.doi.org/10.1590/0037-8682-0120-2016
Access Level:acceso abierto
Palabra clave:Hypothetical proteins
Immuno-proteomic approach
Recombinant proteins
Vaccine
Visceral leishmaniasis
Biología y Biomedicina / Biología
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spelling Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasisDuarte, Mariana CostaLage, Daniela PagliaraMartins, Vívian TamiettiChávez-Fumagalli, Miguel AngelRoatt, Bruno MendesMenezes-Souza, DanielGoulart, Luiz RicardoSoto Álvarez, ManuelTavares, Carlos Alberto PereiraCoelho, Eduardo Antonio FerrazHypothetical proteinsImmuno-proteomic approachRecombinant proteinsVaccineVisceral leishmaniasisBiología y Biomedicina / BiologíaAll rights reserved. Visceral leishmaniasis (VL) is one of the most important tropical diseases worldwide. Although chemotherapy has been widely used to treat this disease, problems related to the development of parasite resistance and side effects associated with the compounds used have been noted. Hence, alternative approaches for VL control are desirable. Some methods, such as vector control and culling of infected dogs, are insufficiently effective, with the latter not ethically recommended. The development of vaccines to prevent VL is a feasible and desirable measure for disease control, for example, some vaccines designed to protect dogs against VL have recently been brought to market. These vaccines are based on the combination of parasite fractions or recombinant proteins with adjuvants that are able to induce cellular immune responses, however, their partial efficacy and the absence of a vaccine to protect against human leishmaniasis underline the need for characterization of new vaccine candidates. This review presents recent advances in control measures for VL based on vaccine development, describing extensively studied antigens, as well as new antigenic proteins recently identified using immuno-proteomic techniquesThis work was supported by grants from Instituto Nacional de Ciência e Tecnologia em Nano-Biofarmacêutica, Rede Nanobiotec/Brasil-Universidade Federal de Uberlândia/CAPES, PRONEX-FAPEMIG (APQ-01019-09), FAPEMIG (CBB-APQ-00819-12 and CBB-APQ-01778-2014), and CNPq (APQ-482976/2012-8, APQ-488237/2013-0, and APQ-467640/2014-9). EAFC and LRG are recipients of the grant from CNPq. MACF is the recipient of grants from FAPEMIG/CAPESSociedade Brasileira de Medicina TropicalDepartamento de Biología MolecularFacultad de Ciencias20162016-07-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/690883https://dx.doi.org/10.1590/0037-8682-0120-2016reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6908832026-06-23T12:46:27Z
dc.title.none.fl_str_mv Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis
title Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis
spellingShingle Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis
Duarte, Mariana Costa
Hypothetical proteins
Immuno-proteomic approach
Recombinant proteins
Vaccine
Visceral leishmaniasis
Biología y Biomedicina / Biología
title_short Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis
title_full Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis
title_fullStr Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis
title_full_unstemmed Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis
title_sort Recent updates and perspectives on approaches for the development of vaccines against visceral leishmaniasis
dc.creator.none.fl_str_mv Duarte, Mariana Costa
Lage, Daniela Pagliara
Martins, Vívian Tamietti
Chávez-Fumagalli, Miguel Angel
Roatt, Bruno Mendes
Menezes-Souza, Daniel
Goulart, Luiz Ricardo
Soto Álvarez, Manuel
Tavares, Carlos Alberto Pereira
Coelho, Eduardo Antonio Ferraz
author Duarte, Mariana Costa
author_facet Duarte, Mariana Costa
Lage, Daniela Pagliara
Martins, Vívian Tamietti
Chávez-Fumagalli, Miguel Angel
Roatt, Bruno Mendes
Menezes-Souza, Daniel
Goulart, Luiz Ricardo
Soto Álvarez, Manuel
Tavares, Carlos Alberto Pereira
Coelho, Eduardo Antonio Ferraz
author_role author
author2 Lage, Daniela Pagliara
Martins, Vívian Tamietti
Chávez-Fumagalli, Miguel Angel
Roatt, Bruno Mendes
Menezes-Souza, Daniel
Goulart, Luiz Ricardo
Soto Álvarez, Manuel
Tavares, Carlos Alberto Pereira
Coelho, Eduardo Antonio Ferraz
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Biología Molecular
Facultad de Ciencias
dc.subject.none.fl_str_mv Hypothetical proteins
Immuno-proteomic approach
Recombinant proteins
Vaccine
Visceral leishmaniasis
Biología y Biomedicina / Biología
topic Hypothetical proteins
Immuno-proteomic approach
Recombinant proteins
Vaccine
Visceral leishmaniasis
Biología y Biomedicina / Biología
description All rights reserved. Visceral leishmaniasis (VL) is one of the most important tropical diseases worldwide. Although chemotherapy has been widely used to treat this disease, problems related to the development of parasite resistance and side effects associated with the compounds used have been noted. Hence, alternative approaches for VL control are desirable. Some methods, such as vector control and culling of infected dogs, are insufficiently effective, with the latter not ethically recommended. The development of vaccines to prevent VL is a feasible and desirable measure for disease control, for example, some vaccines designed to protect dogs against VL have recently been brought to market. These vaccines are based on the combination of parasite fractions or recombinant proteins with adjuvants that are able to induce cellular immune responses, however, their partial efficacy and the absence of a vaccine to protect against human leishmaniasis underline the need for characterization of new vaccine candidates. This review presents recent advances in control measures for VL based on vaccine development, describing extensively studied antigens, as well as new antigenic proteins recently identified using immuno-proteomic techniques
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-07-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/690883
https://dx.doi.org/10.1590/0037-8682-0120-2016
url http://hdl.handle.net/10486/690883
https://dx.doi.org/10.1590/0037-8682-0120-2016
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
publisher.none.fl_str_mv Sociedade Brasileira de Medicina Tropical
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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