Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty

13 Páginas.-- 7 Figuras

Detalles Bibliográficos
Autores: Molina-Gil, Sara, Sotillos, Sol, Espinosa-Vázquez, José Manuel, Almudi, Isabel, Castelli-Gair Hombría, James
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/338492
Acceso en línea:http://hdl.handle.net/10261/338492
https://api.elsevier.com/content/abstract/scopus_id/85171375096
Access Level:acceso abierto
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spelling Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive noveltyMolina-Gil, SaraSotillos, SolEspinosa-Vázquez, José ManuelAlmudi, IsabelCastelli-Gair Hombría, James13 Páginas.-- 7 FigurasThe re-use of genes in new organs forms the base of many evolutionary novelties. A well-characterised case is the recruitment of the posterior spiracle gene network to the Drosophila male genitalia. Here we find that this network has also been co-opted to the testis mesoderm where is required for sperm liberation, providing an example of sequentially repeated developmental co-options. Associated to this co-option event, an evolutionary expression novelty appeared, the activation of the posterior segment determinant Engrailed to the anterior A8 segment controlled by common testis and spiracle regulatory elements. Enhancer deletion shows that A8 anterior Engrailed activation is not required for spiracle development but only necessary in the testis. Our study presents an example of pre-adaptive developmental novelty: the activation of the Engrailed transcription factor in the anterior compartment of the A8 segment where, despite having no specific function, opens the possibility of this developmental factor acquiring one. We propose that recently co-opted networks become interlocked, so that any change to the network because of its function in one organ, will be mirrored by other organs even if it provides no selective advantage to them.We thank Dr. Steve Brown and Dr. Maria Luisa Rivas for helping with the isolation of the upd0.43 cis-regulatory element, Dr. Fernando Casares and his laboratory members for help with Episyrphus cultures and Dr. Judith Kassis for stocks. This work was supported by Ministerio de Ciencia e Innovación grants BFU2016-76528 and PID2019-104656GB-I00 co-funded by the European Regional Development Fund (FEDER) to J.C.-G.H. and by the Spanish Ministry of Science and Innovation (PID2020-116041GB-I00) and Leonardo Grants for Researchers and Cultural Creators 2021 from BBVA Foundation (IN[21]_CMA_BIO_0056) to I. A. The CABD is supported by a María de Maeztu Unit excellence grant CEX-2020-001088-M.Peer reviewedSpringer NatureMinisterio de Ciencia e Innovación (España)European CommissionFundación BBVAConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/338492https://api.elsevier.com/content/abstract/scopus_id/85171375096reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104656GB-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-116041GB-I00Nature communicationsThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1038/s41467-023-41414-3https://doi.org/10.1038/s41467-023-41414-3Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3384922026-05-22T06:33:51Z
dc.title.none.fl_str_mv Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty
title Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty
spellingShingle Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty
Molina-Gil, Sara
title_short Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty
title_full Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty
title_fullStr Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty
title_full_unstemmed Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty
title_sort Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty
dc.creator.none.fl_str_mv Molina-Gil, Sara
Sotillos, Sol
Espinosa-Vázquez, José Manuel
Almudi, Isabel
Castelli-Gair Hombría, James
author Molina-Gil, Sara
author_facet Molina-Gil, Sara
Sotillos, Sol
Espinosa-Vázquez, José Manuel
Almudi, Isabel
Castelli-Gair Hombría, James
author_role author
author2 Sotillos, Sol
Espinosa-Vázquez, José Manuel
Almudi, Isabel
Castelli-Gair Hombría, James
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
European Commission
Fundación BBVA
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description 13 Páginas.-- 7 Figuras
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/338492
https://api.elsevier.com/content/abstract/scopus_id/85171375096
url http://hdl.handle.net/10261/338492
https://api.elsevier.com/content/abstract/scopus_id/85171375096
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
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#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-104656GB-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-116041GB-I00
Nature communications
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1038/s41467-023-41414-3
https://doi.org/10.1038/s41467-023-41414-3
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
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