No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis
Objective: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| Repositorio: | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| OAI Identifier: | oai:iibsantpau.fundanetsuite.com:p16978 |
| Acceso en línea: | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16978 |
| Access Level: | acceso abierto |
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No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysisde Kovel, CGFAftanas, LAleman, AAlexander-Bloch, AFBaune, BTBrack, IBulow, RBusatto, GCarballedo, AConnolly, CGCullen, KRDannlowski, UDavey, CGDima, DDohm, KErwin-Grabner, TFrodl, TFu, CHYHall, GBGlahn, DCGodlewska, BGotlib, IHGoya-Maldonado, RGrabe, HJGroenewold, NAGrotegerd, DGruber, OHarris, MAHarrison, BJHatton, SNHickie, IBHo, TCJahanshad, NKircher, TKramer, BKrug, ALagopoulos, JLeehr, EJLi, MMacMaster, FPMacQueen, GMcIntosh, AMMcLellan, QMedland, SEMueller, BANenadic, IOsipov, EPapmeyer, MPortella, MJReneman, LRosa, PGPSacchet, MDSchnell, KSchrantee, ASim, KSimulionyte, ESindermann, LVan der Werff, SJAVeer, IMVives-Gilabert, YVolzke, HWalter, HWalter, MSchreiner, MWWhalley, HWinter, NWittfeld, KYang, TTYuksel, DZaremba, DThompson, PMVeltman, DJSchmaal, LFrancks, CObjective: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically examined brain anatomical asymmetry in relation to this disorder, and results from those studies have remained inconclusive. At the functional level, some electroencephalography studies have indicated left fronto-cortical hypoactivity and right parietal hypoactivity in depressive disorders, so aspects of lateralized anatomy may also be affected. The authors used pooled individual-level data from data sets collected around the world to investigate differences in laterality in measures of cortical thickness, cortical surface area, and subcortical volume between individuals with major depression and healthy control subjects. Methods: The authors investigated differences in the laterality of thickness and surface area measures of 34 cerebral cortical regions in 2,256 individuals with major depression and 3,504 control subjects from 31 separate data sets, and they investigated volume asymmetries of eight subcortical structures in 2,540 individuals with major depression and 4,230 control subjects from 32 data sets. T-1-weighted MRI data were processedwith a single protocol using FreeSurfer and the Desikan-Killiany atlas. The large sample size provided 80% power to detect effects of the order of Cohen's d=0.1. Results: The largest effect size (Cohen's d) of major depression diagnosis was 0.085 for the thickness asymmetry of the superior temporal cortex, which was not significant after adjustment for multiple testing. Asymmetry measures were not significantly associated with medication use, acute compared with remitted status, first episode compared with recurrent status, or age at onset. Conclusions: Altered brain macro-anatomical asymmetry may be of little relevance to major depression etiology in most cases.AMER PSYCHIATRIC PUBLISHING, INC2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16978AMERICAN JOURNAL OF PSYCHIATRYISSN: 0002953XISSNe: 15357228reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p169782026-06-14T12:41:47Z |
| dc.title.none.fl_str_mv |
No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis |
| title |
No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis |
| spellingShingle |
No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis de Kovel, CGF |
| title_short |
No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis |
| title_full |
No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis |
| title_fullStr |
No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis |
| title_full_unstemmed |
No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis |
| title_sort |
No Alterations of Brain Structural Asymmetry in Major Depressive Disorder: An ENIGMA Consortium Analysis |
| dc.creator.none.fl_str_mv |
de Kovel, CGF Aftanas, L Aleman, A Alexander-Bloch, AF Baune, BT Brack, I Bulow, R Busatto, G Carballedo, A Connolly, CG Cullen, KR Dannlowski, U Davey, CG Dima, D Dohm, K Erwin-Grabner, T Frodl, T Fu, CHY Hall, GB Glahn, DC Godlewska, B Gotlib, IH Goya-Maldonado, R Grabe, HJ Groenewold, NA Grotegerd, D Gruber, O Harris, MA Harrison, BJ Hatton, SN Hickie, IB Ho, TC Jahanshad, N Kircher, T Kramer, B Krug, A Lagopoulos, J Leehr, EJ Li, M MacMaster, FP MacQueen, G McIntosh, AM McLellan, Q Medland, SE Mueller, BA Nenadic, I Osipov, E Papmeyer, M Portella, MJ Reneman, L Rosa, PGP Sacchet, MD Schnell, K Schrantee, A Sim, K Simulionyte, E Sindermann, L Van der Werff, SJA Veer, IM Vives-Gilabert, Y Volzke, H Walter, H Walter, M Schreiner, MW Whalley, H Winter, N Wittfeld, K Yang, TT Yuksel, D Zaremba, D Thompson, PM Veltman, DJ Schmaal, L Francks, C |
| author |
de Kovel, CGF |
| author_facet |
de Kovel, CGF Aftanas, L Aleman, A Alexander-Bloch, AF Baune, BT Brack, I Bulow, R Busatto, G Carballedo, A Connolly, CG Cullen, KR Dannlowski, U Davey, CG Dima, D Dohm, K Erwin-Grabner, T Frodl, T Fu, CHY Hall, GB Glahn, DC Godlewska, B Gotlib, IH Goya-Maldonado, R Grabe, HJ Groenewold, NA Grotegerd, D Gruber, O Harris, MA Harrison, BJ Hatton, SN Hickie, IB Ho, TC Jahanshad, N Kircher, T Kramer, B Krug, A Lagopoulos, J Leehr, EJ Li, M MacMaster, FP MacQueen, G McIntosh, AM McLellan, Q Medland, SE Mueller, BA Nenadic, I Osipov, E Papmeyer, M Portella, MJ Reneman, L Rosa, PGP Sacchet, MD Schnell, K Schrantee, A Sim, K Simulionyte, E Sindermann, L Van der Werff, SJA Veer, IM Vives-Gilabert, Y Volzke, H Walter, H Walter, M Schreiner, MW Whalley, H Winter, N Wittfeld, K Yang, TT Yuksel, D Zaremba, D Thompson, PM Veltman, DJ Schmaal, L Francks, C |
| author_role |
author |
| author2 |
Aftanas, L Aleman, A Alexander-Bloch, AF Baune, BT Brack, I Bulow, R Busatto, G Carballedo, A Connolly, CG Cullen, KR Dannlowski, U Davey, CG Dima, D Dohm, K Erwin-Grabner, T Frodl, T Fu, CHY Hall, GB Glahn, DC Godlewska, B Gotlib, IH Goya-Maldonado, R Grabe, HJ Groenewold, NA Grotegerd, D Gruber, O Harris, MA Harrison, BJ Hatton, SN Hickie, IB Ho, TC Jahanshad, N Kircher, T Kramer, B Krug, A Lagopoulos, J Leehr, EJ Li, M MacMaster, FP MacQueen, G McIntosh, AM McLellan, Q Medland, SE Mueller, BA Nenadic, I Osipov, E Papmeyer, M Portella, MJ Reneman, L Rosa, PGP Sacchet, MD Schnell, K Schrantee, A Sim, K Simulionyte, E Sindermann, L Van der Werff, SJA Veer, IM Vives-Gilabert, Y Volzke, H Walter, H Walter, M Schreiner, MW Whalley, H Winter, N Wittfeld, K Yang, TT Yuksel, D Zaremba, D Thompson, PM Veltman, DJ Schmaal, L Francks, C |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| description |
Objective: Asymmetry is a subtle but pervasive aspect of the human brain, and it may be altered in several psychiatric conditions. MRI studies have shown subtle differences of brain anatomy between people with major depressive disorder and healthy control subjects, but few studies have specifically examined brain anatomical asymmetry in relation to this disorder, and results from those studies have remained inconclusive. At the functional level, some electroencephalography studies have indicated left fronto-cortical hypoactivity and right parietal hypoactivity in depressive disorders, so aspects of lateralized anatomy may also be affected. The authors used pooled individual-level data from data sets collected around the world to investigate differences in laterality in measures of cortical thickness, cortical surface area, and subcortical volume between individuals with major depression and healthy control subjects. Methods: The authors investigated differences in the laterality of thickness and surface area measures of 34 cerebral cortical regions in 2,256 individuals with major depression and 3,504 control subjects from 31 separate data sets, and they investigated volume asymmetries of eight subcortical structures in 2,540 individuals with major depression and 4,230 control subjects from 32 data sets. T-1-weighted MRI data were processedwith a single protocol using FreeSurfer and the Desikan-Killiany atlas. The large sample size provided 80% power to detect effects of the order of Cohen's d=0.1. Results: The largest effect size (Cohen's d) of major depression diagnosis was 0.085 for the thickness asymmetry of the superior temporal cortex, which was not significant after adjustment for multiple testing. Asymmetry measures were not significantly associated with medication use, acute compared with remitted status, first episode compared with recurrent status, or age at onset. Conclusions: Altered brain macro-anatomical asymmetry may be of little relevance to major depression etiology in most cases. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
| status_str |
publishedVersion |
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https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16978 |
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https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16978 |
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Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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AMER PSYCHIATRIC PUBLISHING, INC |
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AMER PSYCHIATRIC PUBLISHING, INC |
| dc.source.none.fl_str_mv |
AMERICAN JOURNAL OF PSYCHIATRY ISSN: 0002953X ISSNe: 15357228 reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
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Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
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r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
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r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
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1869407651617570816 |
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15,812455 |