A fast method for monitoring the shifts in resonance frequency and dissipation of the QCM sensors of a Monolithic array in biosensing applications
[EN] Improvement of data acquisition rate remains as an important challenge in applications with Quartz Crystal Microbalance (QCM) technology where high throughput is required. To address this challenge, we developed a fast method capable of measuring the response of a large number of sensors and/or...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | inglés |
| OAI Identifier: | oai:riunet.upv.es:10251/161161 |
| Acceso en línea: | https://riunet.upv.es/handle/10251/161161 |
| Access Level: | acceso abierto |
| Palabra clave: | Biosensor Fast acquisition Monolithic Quartz Crystal Microbalance (MQCM) Multiple overtones Sensor array devices TECNOLOGIA ELECTRONICA |
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A fast method for monitoring the shifts in resonance frequency and dissipation of the QCM sensors of a Monolithic array in biosensing applicationsFERNÁNDEZ DÍAZ, ROMÁN|||0000-0002-8883-4653García Narbón, José Vicente|||0000-0001-6303-8258Arnau Vives, Antonio|||0000-0002-5709-1690Jiménez Jiménez, Yolanda|||0000-0003-4835-9007Calero-Alcarria, María Del SeñorReiviakine, IlyaBiosensorFast acquisitionMonolithic Quartz Crystal Microbalance (MQCM)Multiple overtonesSensor array devicesTECNOLOGIA ELECTRONICA[EN] Improvement of data acquisition rate remains as an important challenge in applications with Quartz Crystal Microbalance (QCM) technology where high throughput is required. To address this challenge, we developed a fast method capable of measuring the response of a large number of sensors and/or overtones, with a high time resolution. Our method, which can be implemented in a low-cost readout electronic circuit, is based on the estimation of fr (frequency shift) and D (dissipation shift) from measurements of the sensor response obtained at a single driving frequency. By replacing slow fitting procedures with a direct calculation, the time resolution is only limited by the physical characteristics of the sensor (resonance frequency and quality factor), but not by the method itself. Capabilities of the method are demonstrated by monitoring multiple overtones with a single 5 MHz sensor and a Monolithic QCM array comprising 24 50MHz-sensors. Accuracy of the method is validated and compared with the state-of-the-art, as well as with a reference method based on impedance analysis.This work was supported in part by the Ministerio de Economía, Industria y Competitividad de España-Agencia Estatal de Investigación with Fondo Europeo de Desarrollo Regional (FEDER) Funds under Grant AGL2016-77702-R and in part by the European Commission Horizon 2020 Programme (Capturing non-amplified tumor circulating DNA with ultrasound hydrodynamics) under Agreement H2020-FETOPEN-2016-2017/737212-CATCH-UDNA. The work of María Calero was supported by the Spanish Ministry of Economy, Industry and Competitiveness, Madrid, Spain, under Grant BES-2017-080246.Institute of Electrical and Electronics EngineersDepartamento de Ingeniería ElectrónicaEscuela Técnica Superior de Ingeniería de TelecomunicaciónEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialCentro de Investigación e Innovación en BioingenieríaEuropean CommissionEuropean Regional Development FundAgencia Estatal de InvestigaciónMinisterio de Economía y CompetitividadRepositorio Institucional de la Universitat Politècnica de València Riunet20212021-03-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/161161reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengEuropean Commission https://doi.org/10.13039/501100000780 H2020 737212 Capturing non-Amplified Tumor Circulating DNA with Ultrasound HydrodynamicsMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 AGL2016-77702-R DISEÑO DE UN BIOSENSOR DE ADN BASADO EN TECNOLOGIA HFF-QCM PARA LA DETECCION DE SUSTANCIAS ADULTERANTES EN MIELMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Programa Estatal de Promoción del Talento y su Empleabilidad BES-2017-080246open accesshttp://purl.org/coar/access_right/c_abf2Reserva de todos los derechoshttp://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1611612026-06-13T07:49:27Z |
| dc.title.none.fl_str_mv |
A fast method for monitoring the shifts in resonance frequency and dissipation of the QCM sensors of a Monolithic array in biosensing applications |
| title |
A fast method for monitoring the shifts in resonance frequency and dissipation of the QCM sensors of a Monolithic array in biosensing applications |
| spellingShingle |
A fast method for monitoring the shifts in resonance frequency and dissipation of the QCM sensors of a Monolithic array in biosensing applications FERNÁNDEZ DÍAZ, ROMÁN|||0000-0002-8883-4653 Biosensor Fast acquisition Monolithic Quartz Crystal Microbalance (MQCM) Multiple overtones Sensor array devices TECNOLOGIA ELECTRONICA |
| title_short |
A fast method for monitoring the shifts in resonance frequency and dissipation of the QCM sensors of a Monolithic array in biosensing applications |
| title_full |
A fast method for monitoring the shifts in resonance frequency and dissipation of the QCM sensors of a Monolithic array in biosensing applications |
| title_fullStr |
A fast method for monitoring the shifts in resonance frequency and dissipation of the QCM sensors of a Monolithic array in biosensing applications |
| title_full_unstemmed |
A fast method for monitoring the shifts in resonance frequency and dissipation of the QCM sensors of a Monolithic array in biosensing applications |
| title_sort |
A fast method for monitoring the shifts in resonance frequency and dissipation of the QCM sensors of a Monolithic array in biosensing applications |
| dc.creator.none.fl_str_mv |
FERNÁNDEZ DÍAZ, ROMÁN|||0000-0002-8883-4653 García Narbón, José Vicente|||0000-0001-6303-8258 Arnau Vives, Antonio|||0000-0002-5709-1690 Jiménez Jiménez, Yolanda|||0000-0003-4835-9007 Calero-Alcarria, María Del Señor Reiviakine, Ilya |
| author |
FERNÁNDEZ DÍAZ, ROMÁN|||0000-0002-8883-4653 |
| author_facet |
FERNÁNDEZ DÍAZ, ROMÁN|||0000-0002-8883-4653 García Narbón, José Vicente|||0000-0001-6303-8258 Arnau Vives, Antonio|||0000-0002-5709-1690 Jiménez Jiménez, Yolanda|||0000-0003-4835-9007 Calero-Alcarria, María Del Señor Reiviakine, Ilya |
| author_role |
author |
| author2 |
García Narbón, José Vicente|||0000-0001-6303-8258 Arnau Vives, Antonio|||0000-0002-5709-1690 Jiménez Jiménez, Yolanda|||0000-0003-4835-9007 Calero-Alcarria, María Del Señor Reiviakine, Ilya |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Ingeniería Electrónica Escuela Técnica Superior de Ingeniería de Telecomunicación Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial Centro de Investigación e Innovación en Bioingeniería European Commission European Regional Development Fund Agencia Estatal de Investigación Ministerio de Economía y Competitividad Repositorio Institucional de la Universitat Politècnica de València Riunet |
| dc.subject.none.fl_str_mv |
Biosensor Fast acquisition Monolithic Quartz Crystal Microbalance (MQCM) Multiple overtones Sensor array devices TECNOLOGIA ELECTRONICA |
| topic |
Biosensor Fast acquisition Monolithic Quartz Crystal Microbalance (MQCM) Multiple overtones Sensor array devices TECNOLOGIA ELECTRONICA |
| description |
[EN] Improvement of data acquisition rate remains as an important challenge in applications with Quartz Crystal Microbalance (QCM) technology where high throughput is required. To address this challenge, we developed a fast method capable of measuring the response of a large number of sensors and/or overtones, with a high time resolution. Our method, which can be implemented in a low-cost readout electronic circuit, is based on the estimation of fr (frequency shift) and D (dissipation shift) from measurements of the sensor response obtained at a single driving frequency. By replacing slow fitting procedures with a direct calculation, the time resolution is only limited by the physical characteristics of the sensor (resonance frequency and quality factor), but not by the method itself. Capabilities of the method are demonstrated by monitoring multiple overtones with a single 5 MHz sensor and a Monolithic QCM array comprising 24 50MHz-sensors. Accuracy of the method is validated and compared with the state-of-the-art, as well as with a reference method based on impedance analysis. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021-03-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://riunet.upv.es/handle/10251/161161 |
| url |
https://riunet.upv.es/handle/10251/161161 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
European Commission https://doi.org/10.13039/501100000780 H2020 737212 Capturing non-Amplified Tumor Circulating DNA with Ultrasound Hydrodynamics Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 AGL2016-77702-R DISEÑO DE UN BIOSENSOR DE ADN BASADO EN TECNOLOGIA HFF-QCM PARA LA DETECCION DE SUSTANCIAS ADULTERANTES EN MIEL Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 Programa Estatal de Promoción del Talento y su Empleabilidad BES-2017-080246 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Reserva de todos los derechos http://rightsstatements.org/vocab/InC/1.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 Reserva de todos los derechos http://rightsstatements.org/vocab/InC/1.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Institute of Electrical and Electronics Engineers |
| publisher.none.fl_str_mv |
Institute of Electrical and Electronics Engineers |
| dc.source.none.fl_str_mv |
reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname:Universitat Politècnica de València (UPV) |
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Universitat Politècnica de València (UPV) |
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RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
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RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
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