MicroRNA-mediated control of myocardial infarction in diabetes
Diabetes mellitus is a global public health problem whose cases will continue to rise along with the pro-gressive increase in obesity and the aging of the population. People with diabetes exhibit higher risk of cardiovascular complications, especially myocardial infarction (MI). microRNAs (miRNAs) a...
| Authors: | , , , |
|---|---|
| Format: | article |
| Status: | Published version |
| Publication Date: | 2023 |
| Country: | España |
| Institution: | INCLIVA |
| Repository: | r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
| OAI Identifier: | oai:incliva.fundanetsuite.com:p16769 |
| Online Access: | https://incliva.portalinvestigacion.com/publicaciones/16769 |
| Access Level: | Open access |
| Keyword: | microRNA Diabetes Myocardial infarction |
| Summary: | Diabetes mellitus is a global public health problem whose cases will continue to rise along with the pro-gressive increase in obesity and the aging of the population. People with diabetes exhibit higher risk of cardiovascular complications, especially myocardial infarction (MI). microRNAs (miRNAs) are evolution-ary conserved small non-coding RNAs involved in the regulation of biological processes by interfering in gene expression at the post-transcriptional level. Accumulating studies in the last two decades have uncovered the role of stage-specific miRNAs associated with key pathobiological events observed in the hearts of people with diabetes and MI, including cardiomyocyte death, angiogenesis, inflammatory re-sponse, myocardial remodeling, and myocardial lipotoxicity. A better understanding of the importance of these miRNAs and their targets may provide novel opportunities for RNA-based therapeutic interventions to address the increased risk of MI in diabetes.(c) 2022 Elsevier Inc. All rights reserved. |
|---|