Sex-dependent role of CD300f immune receptor in generalized anxiety disorder.

Generalized Anxiety Disorder (GAD) presents a high prevalence in the population, leading to distress and disability. Immune system alterations have been associated with anxiety-related behaviors in rodents and GAD patients. CD300f immune receptors are highly expressed in microglia and participate no...

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Autores: Kaufmann, Fernanda N., Lago, Natalia, Alí-Ruiz, Daniela, Jansen, Karen, Dias de Mattos Souza, Luciano, Silva, Ricardo, Lara, Diogo R., Ghisleni, Gabriele, Peluffo, Hugo, Kaster, Manuella P.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/207405
Acceso en línea:https://hdl.handle.net/2445/207405
Access Level:acceso abierto
Palabra clave:Ansietat
Sistema immunitari
Receptors cel·lulars
Depressió psíquica
Polimorfisme genètic
Diferències entre sexes
Anxiety
Immune system
Cell receptors
Mental depression
Genetic polymorphisms
Sex differences
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spelling Sex-dependent role of CD300f immune receptor in generalized anxiety disorder.Kaufmann, Fernanda N.Lago, NataliaAlí-Ruiz, DanielaJansen, KarenDias de Mattos Souza, LucianoSilva, RicardoLara, Diogo R.Ghisleni, GabrielePeluffo, HugoKaster, Manuella P.AnsietatSistema immunitariReceptors cel·lularsDepressió psíquicaPolimorfisme genèticDiferències entre sexesAnxietyImmune systemCell receptorsMental depressionGenetic polymorphismsSex differencesGeneralized Anxiety Disorder (GAD) presents a high prevalence in the population, leading to distress and disability. Immune system alterations have been associated with anxiety-related behaviors in rodents and GAD patients. CD300f immune receptors are highly expressed in microglia and participate not only in the modulation of immune responses but also in pruning and reshaping synapses. It was recently demonstrated that CD300f might be influential in the pathogenesis of depression in a sex-dependent manner. Here, we evaluated the role of CD300f immune receptor in anxiety, using CD300f knockout mice (CD300f-/-) and patients with GAD. We observed that male CD300f-/- mice had numerous behavioral changes associated with a low-anxiety phenotype, including increased open field central locomotion and rearing behaviors, more exploration in the open arms of the elevated plus-maze test, and decreased latency to eat in the novelty suppressed feeding test. In a cross-sectional population-based study, including 1111 subjects, we evaluated a common single-nucleotide polymorphism rs2034310 (C/T) in the cytoplasmatic tail of CD300f gene in individuals with GAD. Notably, we observed that the T allele of the rs2034310 polymorphism conferred protection against GAD in men, even after adjusting for confounding variables. Overall, our data demonstrate that CD300f immune receptors are involved in the modulation of pathological anxiety behaviors in a sex-dependent manner. The biological basis of these sex differences is still poorly understood, but it may provide significant clues regarding the neuropathophysiological mechanisms of GAD and can pave the way for future specific pharmacological interventions.Elsevier2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/207405Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document https://doi.org/10.1016/j.bbih.2020.100191Brain, Behavior, and Immunity - Health (BBI - Health), 2020, vol. 14, num.11https://doi.org/10.1016/j.bbih.2020.100191CC BY-NC-ND (c) Kaufmann, Fernanda N., 2020, et al.info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2074052026-05-27T06:46:51Z
dc.title.none.fl_str_mv Sex-dependent role of CD300f immune receptor in generalized anxiety disorder.
title Sex-dependent role of CD300f immune receptor in generalized anxiety disorder.
spellingShingle Sex-dependent role of CD300f immune receptor in generalized anxiety disorder.
Kaufmann, Fernanda N.
Ansietat
Sistema immunitari
Receptors cel·lulars
Depressió psíquica
Polimorfisme genètic
Diferències entre sexes
Anxiety
Immune system
Cell receptors
Mental depression
Genetic polymorphisms
Sex differences
title_short Sex-dependent role of CD300f immune receptor in generalized anxiety disorder.
title_full Sex-dependent role of CD300f immune receptor in generalized anxiety disorder.
title_fullStr Sex-dependent role of CD300f immune receptor in generalized anxiety disorder.
title_full_unstemmed Sex-dependent role of CD300f immune receptor in generalized anxiety disorder.
title_sort Sex-dependent role of CD300f immune receptor in generalized anxiety disorder.
dc.creator.none.fl_str_mv Kaufmann, Fernanda N.
Lago, Natalia
Alí-Ruiz, Daniela
Jansen, Karen
Dias de Mattos Souza, Luciano
Silva, Ricardo
Lara, Diogo R.
Ghisleni, Gabriele
Peluffo, Hugo
Kaster, Manuella P.
author Kaufmann, Fernanda N.
author_facet Kaufmann, Fernanda N.
Lago, Natalia
Alí-Ruiz, Daniela
Jansen, Karen
Dias de Mattos Souza, Luciano
Silva, Ricardo
Lara, Diogo R.
Ghisleni, Gabriele
Peluffo, Hugo
Kaster, Manuella P.
author_role author
author2 Lago, Natalia
Alí-Ruiz, Daniela
Jansen, Karen
Dias de Mattos Souza, Luciano
Silva, Ricardo
Lara, Diogo R.
Ghisleni, Gabriele
Peluffo, Hugo
Kaster, Manuella P.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ansietat
Sistema immunitari
Receptors cel·lulars
Depressió psíquica
Polimorfisme genètic
Diferències entre sexes
Anxiety
Immune system
Cell receptors
Mental depression
Genetic polymorphisms
Sex differences
topic Ansietat
Sistema immunitari
Receptors cel·lulars
Depressió psíquica
Polimorfisme genètic
Diferències entre sexes
Anxiety
Immune system
Cell receptors
Mental depression
Genetic polymorphisms
Sex differences
description Generalized Anxiety Disorder (GAD) presents a high prevalence in the population, leading to distress and disability. Immune system alterations have been associated with anxiety-related behaviors in rodents and GAD patients. CD300f immune receptors are highly expressed in microglia and participate not only in the modulation of immune responses but also in pruning and reshaping synapses. It was recently demonstrated that CD300f might be influential in the pathogenesis of depression in a sex-dependent manner. Here, we evaluated the role of CD300f immune receptor in anxiety, using CD300f knockout mice (CD300f-/-) and patients with GAD. We observed that male CD300f-/- mice had numerous behavioral changes associated with a low-anxiety phenotype, including increased open field central locomotion and rearing behaviors, more exploration in the open arms of the elevated plus-maze test, and decreased latency to eat in the novelty suppressed feeding test. In a cross-sectional population-based study, including 1111 subjects, we evaluated a common single-nucleotide polymorphism rs2034310 (C/T) in the cytoplasmatic tail of CD300f gene in individuals with GAD. Notably, we observed that the T allele of the rs2034310 polymorphism conferred protection against GAD in men, even after adjusting for confounding variables. Overall, our data demonstrate that CD300f immune receptors are involved in the modulation of pathological anxiety behaviors in a sex-dependent manner. The biological basis of these sex differences is still poorly understood, but it may provide significant clues regarding the neuropathophysiological mechanisms of GAD and can pave the way for future specific pharmacological interventions.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/207405
url https://hdl.handle.net/2445/207405
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document https://doi.org/10.1016/j.bbih.2020.100191
Brain, Behavior, and Immunity - Health (BBI - Health), 2020, vol. 14, num.11
https://doi.org/10.1016/j.bbih.2020.100191
dc.rights.none.fl_str_mv CC BY-NC-ND (c) Kaufmann, Fernanda N., 2020, et al.
info:eu-repo/semantics/openAccess
rights_invalid_str_mv CC BY-NC-ND (c) Kaufmann, Fernanda N., 2020, et al.
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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