Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity: the role of cardiorespiratory fitness

Objectives: Fat depots localization has a critical role in the metabolic health status of adults. Nevertheless, whether that is also the case in children remains under- studied. Therefore, the aims of this study were: (i) to examine the differ-ences between metabolically healthy (MHO) and unhealthy...

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Authors: Cadenas-Sánchez, Cristina, Medrano Echeverría, María, Villanueva Larre, Arantxa, Cabeza Laguna, Rafael, Idoate, Fernando, Osés Recalde, Maddi, Rodríguez Vigil, Beatriz, Álvarez de Eulate, Natalia, Alberdi Aldasoro, Nerea, Ortega, Francisco B., Labayen Goñi, Idoia
Format: article
Status:Published version
Publication Date:2023
Country:España
Institution:Universidad Pública de Navarra
Repository:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/45959
Online Access:https://hdl.handle.net/2454/45959
Access Level:Open access
Keyword:Abdominal subcutaneous fat
Aerobic capacity
Hepatic fat
Lumbar bone marrow fat
Pancreatic fat
Psoas fat
Visceral fat
Youth
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oai_identifier_str oai:academica-e.unavarra.es:2454/45959
network_acronym_str ES
network_name_str España
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dc.title.none.fl_str_mv Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity: the role of cardiorespiratory fitness
title Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity: the role of cardiorespiratory fitness
spellingShingle Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity: the role of cardiorespiratory fitness
Cadenas-Sánchez, Cristina
Abdominal subcutaneous fat
Aerobic capacity
Hepatic fat
Lumbar bone marrow fat
Pancreatic fat
Psoas fat
Visceral fat
Youth
title_short Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity: the role of cardiorespiratory fitness
title_full Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity: the role of cardiorespiratory fitness
title_fullStr Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity: the role of cardiorespiratory fitness
title_full_unstemmed Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity: the role of cardiorespiratory fitness
title_sort Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity: the role of cardiorespiratory fitness
dc.creator.none.fl_str_mv Cadenas-Sánchez, Cristina
Medrano Echeverría, María
Villanueva Larre, Arantxa
Cabeza Laguna, Rafael
Idoate, Fernando
Osés Recalde, Maddi
Rodríguez Vigil, Beatriz
Álvarez de Eulate, Natalia
Alberdi Aldasoro, Nerea
Ortega, Francisco B.
Labayen Goñi, Idoia
author Cadenas-Sánchez, Cristina
author_facet Cadenas-Sánchez, Cristina
Medrano Echeverría, María
Villanueva Larre, Arantxa
Cabeza Laguna, Rafael
Idoate, Fernando
Osés Recalde, Maddi
Rodríguez Vigil, Beatriz
Álvarez de Eulate, Natalia
Alberdi Aldasoro, Nerea
Ortega, Francisco B.
Labayen Goñi, Idoia
author_role author
author2 Medrano Echeverría, María
Villanueva Larre, Arantxa
Cabeza Laguna, Rafael
Idoate, Fernando
Osés Recalde, Maddi
Rodríguez Vigil, Beatriz
Álvarez de Eulate, Natalia
Alberdi Aldasoro, Nerea
Ortega, Francisco B.
Labayen Goñi, Idoia
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ciencias de la Salud
Ingeniería Eléctrica, Electrónica y de Comunicación
Institute on Innovation and Sustainable Development in Food Chain - ISFOOD
Institute of Smart Cities - ISC
Osasun Zientziak
Ingeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren
dc.subject.none.fl_str_mv Abdominal subcutaneous fat
Aerobic capacity
Hepatic fat
Lumbar bone marrow fat
Pancreatic fat
Psoas fat
Visceral fat
Youth
topic Abdominal subcutaneous fat
Aerobic capacity
Hepatic fat
Lumbar bone marrow fat
Pancreatic fat
Psoas fat
Visceral fat
Youth
description Objectives: Fat depots localization has a critical role in the metabolic health status of adults. Nevertheless, whether that is also the case in children remains under- studied. Therefore, the aims of this study were: (i) to examine the differ-ences between metabolically healthy (MHO) and unhealthy (MUO) overweight/obesity phenotypes on specific abdominal fat depots, and (ii) to further explore whether cardiorespiratory fitness plays a major role in the differences between metabolic phenotypes among children with overweight/obesity. Methods: A total of 114 children with overweight/obesity (10.6 ±1.1 years, 62 girls) were included. Children were classified as MHO (n=68) or MUO. visceral (VAT), abdominal subcutaneous (ASAT), intermuscular abdominal (IMAAT), psoas, hepatic, pancreatic, and lumbar bone marrow adipose tissues were measured by magnetic resonance imaging. Cardiorespiratory fitness was assessed using the 20 m shuttle run test. Results: MHO children had lower VAT and ASAT contents and psoas fat fraction compared to MUO children (difference =12.4%– 25.8%, all p<0.035). MUO- unfit had more VAT and ASAT content than those MUO- fit and MHO- fit (difference =34.8%– 45.3%, all p<0.044). MUO- unfit shows also greater IMAAT fat fraction than those MUO- fit and MHO- fit peers (difference =16.4%– 13.9% respectively, all p≤0.001). In addition, MHO- unfit presented higher IMAAT fat fraction than MHO- fit (difference =13.4%, p<0.001). MUO- unfit presented higher psoas fat fraction than MHO- fit (difference =29.1%, p=0.008). Conclusions: VAT together with ASAT and psoas fat fraction, were lower in MHO than in MUO children. Further, we also observed that being fit, regardless of metabolic phenotype, has a protective role over the specific abdominal fat depots among children with overweight/obesity.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/45959
url https://hdl.handle.net/2454/45959
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/101028929
info:eu-repo/grantAgreement/MINECO//PI13%2F01335
info:eu-repo/grantAgreement/MINECO//DEP2016-78377-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/FJC2018-037925-I
info:eu-repo/grantAgreement/Gobierno de Navarra//0011-1365-2019-000085
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
reponame_str Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
collection Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
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spelling Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity: the role of cardiorespiratory fitnessCadenas-Sánchez, CristinaMedrano Echeverría, MaríaVillanueva Larre, ArantxaCabeza Laguna, RafaelIdoate, FernandoOsés Recalde, MaddiRodríguez Vigil, BeatrizÁlvarez de Eulate, NataliaAlberdi Aldasoro, NereaOrtega, Francisco B.Labayen Goñi, IdoiaAbdominal subcutaneous fatAerobic capacityHepatic fatLumbar bone marrow fatPancreatic fatPsoas fatVisceral fatYouthObjectives: Fat depots localization has a critical role in the metabolic health status of adults. Nevertheless, whether that is also the case in children remains under- studied. Therefore, the aims of this study were: (i) to examine the differ-ences between metabolically healthy (MHO) and unhealthy (MUO) overweight/obesity phenotypes on specific abdominal fat depots, and (ii) to further explore whether cardiorespiratory fitness plays a major role in the differences between metabolic phenotypes among children with overweight/obesity. Methods: A total of 114 children with overweight/obesity (10.6 ±1.1 years, 62 girls) were included. Children were classified as MHO (n=68) or MUO. visceral (VAT), abdominal subcutaneous (ASAT), intermuscular abdominal (IMAAT), psoas, hepatic, pancreatic, and lumbar bone marrow adipose tissues were measured by magnetic resonance imaging. Cardiorespiratory fitness was assessed using the 20 m shuttle run test. Results: MHO children had lower VAT and ASAT contents and psoas fat fraction compared to MUO children (difference =12.4%– 25.8%, all p<0.035). MUO- unfit had more VAT and ASAT content than those MUO- fit and MHO- fit (difference =34.8%– 45.3%, all p<0.044). MUO- unfit shows also greater IMAAT fat fraction than those MUO- fit and MHO- fit peers (difference =16.4%– 13.9% respectively, all p≤0.001). In addition, MHO- unfit presented higher IMAAT fat fraction than MHO- fit (difference =13.4%, p<0.001). MUO- unfit presented higher psoas fat fraction than MHO- fit (difference =29.1%, p=0.008). Conclusions: VAT together with ASAT and psoas fat fraction, were lower in MHO than in MUO children. Further, we also observed that being fit, regardless of metabolic phenotype, has a protective role over the specific abdominal fat depots among children with overweight/obesity.This project was funded by the Spanish Ministry of Health “Fondos de Investigación Sanitaria del Instituto de Salud Carlos III” (PI13/01335), the Spanish Ministry of Industry and Competitiveness (DEP2016-78377-R), and by EU Fondos Estructurales de la Unión Europea (FEDER) funds (“Una manera de hacer Europa”). Support was also provided by the Department of Economic Development of the Government of Navarra (0011-1365-2019-000085). Dr Cadenas-Sanchez is supported by the Spanish Ministry of Science and Innovation (FJC2018-037925-I) and by a grant from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska Curie grant agreement No. 101028929. Dr Medrano is supported by the European Union NextGeneration EU and the Spanish Ministry of Universities (postdoctoral fellowship Margarita Salas, 572827-MS15). The other authors received no additional funding.WileyCiencias de la SaludIngeniería Eléctrica, Electrónica y de ComunicaciónInstitute on Innovation and Sustainable Development in Food Chain - ISFOODInstitute of Smart Cities - ISCOsasun ZientziakIngeniaritza Elektrikoa, Elektronikoaren eta Telekomunikazio Ingeniaritzaren2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/45959reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/European Commission/Horizon 2020 Framework Programme/101028929info:eu-repo/grantAgreement/MINECO//PI13%2F01335info:eu-repo/grantAgreement/MINECO//DEP2016-78377-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/FJC2018-037925-Iinfo:eu-repo/grantAgreement/Gobierno de Navarra//0011-1365-2019-000085© The Author(s) 2023. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/459592026-06-17T12:41:47Z
score 15,81155

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