Uncovering the Mast Cell Response to Mycobacterium tuberculosis

The immunologic mechanisms that contribute to the response to Mycobacterium tuberculosis infection still represent a challenge in the clinical management and scientific understanding of tuberculosis disease. In this scenario, the role of the different cells involved in the host response, either in t...

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Detalles Bibliográficos
Autores: Torres-Atencio, Ivonne, Campble, Ariadne, Goodridge, Amador, Martín Andorrà, Margarita
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/186606
Acceso en línea:https://hdl.handle.net/2445/186606
Access Level:acceso abierto
Palabra clave:Mycobacterium tuberculosis
Mastòcits
Histamina
Mast cells
Histamine
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spelling Uncovering the Mast Cell Response to Mycobacterium tuberculosisTorres-Atencio, IvonneCampble, AriadneGoodridge, AmadorMartín Andorrà, MargaritaMycobacterium tuberculosisMastòcitsHistaminaMycobacterium tuberculosisMast cellsHistamineThe immunologic mechanisms that contribute to the response to Mycobacterium tuberculosis infection still represent a challenge in the clinical management and scientific understanding of tuberculosis disease. In this scenario, the role of the different cells involved in the host response, either in terms of innate or adaptive immunity, remains key for defeating this disease. Among this coordinated cell response, mast cells remain key for defeating tuberculosis infection and disease. Together with its effector's molecules, membrane receptors as well as its anatomical locations, mast cells play a crucial role in theestablishment and perpetuation of the inflammatory response that leads to the generation of the granuloma during tuberculosis. This review highlights the current evidences that support the notion of mast cells as key link to reinforce the advancements in tuberculosis diagnosis, disease progression, and novel therapeutic strategies. Special focus on mast cells capacity for the modulation of the inflammatory response among patients suffering multidrug resistant tuberculosis or in co-infections such as current COVID-19 pandemic.Frontiers Media2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/186606Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fimmu.2022.886044Frontiers in Immunology, 2022, vol. 13https://doi.org/10.3389/fimmu.2022.886044cc-by (c) Torres-Atencio, Ivonne et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1866062026-05-27T06:46:51Z
dc.title.none.fl_str_mv Uncovering the Mast Cell Response to Mycobacterium tuberculosis
title Uncovering the Mast Cell Response to Mycobacterium tuberculosis
spellingShingle Uncovering the Mast Cell Response to Mycobacterium tuberculosis
Torres-Atencio, Ivonne
Mycobacterium tuberculosis
Mastòcits
Histamina
Mycobacterium tuberculosis
Mast cells
Histamine
title_short Uncovering the Mast Cell Response to Mycobacterium tuberculosis
title_full Uncovering the Mast Cell Response to Mycobacterium tuberculosis
title_fullStr Uncovering the Mast Cell Response to Mycobacterium tuberculosis
title_full_unstemmed Uncovering the Mast Cell Response to Mycobacterium tuberculosis
title_sort Uncovering the Mast Cell Response to Mycobacterium tuberculosis
dc.creator.none.fl_str_mv Torres-Atencio, Ivonne
Campble, Ariadne
Goodridge, Amador
Martín Andorrà, Margarita
author Torres-Atencio, Ivonne
author_facet Torres-Atencio, Ivonne
Campble, Ariadne
Goodridge, Amador
Martín Andorrà, Margarita
author_role author
author2 Campble, Ariadne
Goodridge, Amador
Martín Andorrà, Margarita
author2_role author
author
author
dc.subject.none.fl_str_mv Mycobacterium tuberculosis
Mastòcits
Histamina
Mycobacterium tuberculosis
Mast cells
Histamine
topic Mycobacterium tuberculosis
Mastòcits
Histamina
Mycobacterium tuberculosis
Mast cells
Histamine
description The immunologic mechanisms that contribute to the response to Mycobacterium tuberculosis infection still represent a challenge in the clinical management and scientific understanding of tuberculosis disease. In this scenario, the role of the different cells involved in the host response, either in terms of innate or adaptive immunity, remains key for defeating this disease. Among this coordinated cell response, mast cells remain key for defeating tuberculosis infection and disease. Together with its effector's molecules, membrane receptors as well as its anatomical locations, mast cells play a crucial role in theestablishment and perpetuation of the inflammatory response that leads to the generation of the granuloma during tuberculosis. This review highlights the current evidences that support the notion of mast cells as key link to reinforce the advancements in tuberculosis diagnosis, disease progression, and novel therapeutic strategies. Special focus on mast cells capacity for the modulation of the inflammatory response among patients suffering multidrug resistant tuberculosis or in co-infections such as current COVID-19 pandemic.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/186606
url https://hdl.handle.net/2445/186606
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2022.886044
Frontiers in Immunology, 2022, vol. 13
https://doi.org/10.3389/fimmu.2022.886044
dc.rights.none.fl_str_mv cc-by (c) Torres-Atencio, Ivonne et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Torres-Atencio, Ivonne et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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