Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome

Background: Basal forebrain (BF) degeneration occurs in Down syndrome (DS)-associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS. Methods: We inc...

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Autores: Aranha, Mateus Rozalem, González-Ortiz, Sofía, Fortea, Juan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/61249
Acceso en línea:http://hdl.handle.net/10230/61249
http://dx.doi.org/10.1002/alz.12999
Access Level:acceso abierto
Palabra clave:Alzheimer&apos
s disease
Down syndrome
Basal forebrain
Biomarkers
Cholinergic
Magnetic resonance imaging
Neuroimaging
Volumetry
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spelling Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndromeAranha, Mateus RozalemGonzález-Ortiz, SofíaFortea, JuanAlzheimer&aposs diseaseDown syndromeBasal forebrainBiomarkersCholinergicMagnetic resonance imagingNeuroimagingVolumetryBackground: Basal forebrain (BF) degeneration occurs in Down syndrome (DS)-associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS. Methods: We included 234 adults with DS (150 asymptomatic, 38 prodromal AD, and 46 AD dementia) and 147 euploid controls. BF volumes were extracted from T-weighted magnetic resonance images using a stereotactic atlas in SPM12. We assessed BF volume changes with age and along the clinical AD continuum and their relationship to cognitive performance, cerebrospinal fluid (CSF) and plasma amyloid/tau/neurodegeneration biomarkers, and hippocampal volume. Results: In DS, BF volumes decreased with age and along the clinical AD continuum and significantly correlated with amyloid, tau, and neurofilament light chain changes in CSF and plasma, hippocampal volume, and cognitive performance. Discussion: BF atrophy is a potentially valuable neuroimaging biomarker of AD-related cholinergic neurodegeneration in DS.Elsevier202420242023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/61249http://dx.doi.org/10.1002/alz.12999reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésAlzheimers Dement. 2023 Nov;19(11):4817-27© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/612492026-05-29T05:05:01Z
dc.title.none.fl_str_mv Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
title Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
spellingShingle Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
Aranha, Mateus Rozalem
Alzheimer&apos
s disease
Down syndrome
Basal forebrain
Biomarkers
Cholinergic
Magnetic resonance imaging
Neuroimaging
Volumetry
title_short Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
title_full Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
title_fullStr Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
title_full_unstemmed Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
title_sort Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome
dc.creator.none.fl_str_mv Aranha, Mateus Rozalem
González-Ortiz, Sofía
Fortea, Juan
author Aranha, Mateus Rozalem
author_facet Aranha, Mateus Rozalem
González-Ortiz, Sofía
Fortea, Juan
author_role author
author2 González-Ortiz, Sofía
Fortea, Juan
author2_role author
author
dc.subject.none.fl_str_mv Alzheimer&apos
s disease
Down syndrome
Basal forebrain
Biomarkers
Cholinergic
Magnetic resonance imaging
Neuroimaging
Volumetry
topic Alzheimer&apos
s disease
Down syndrome
Basal forebrain
Biomarkers
Cholinergic
Magnetic resonance imaging
Neuroimaging
Volumetry
description Background: Basal forebrain (BF) degeneration occurs in Down syndrome (DS)-associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS. Methods: We included 234 adults with DS (150 asymptomatic, 38 prodromal AD, and 46 AD dementia) and 147 euploid controls. BF volumes were extracted from T-weighted magnetic resonance images using a stereotactic atlas in SPM12. We assessed BF volume changes with age and along the clinical AD continuum and their relationship to cognitive performance, cerebrospinal fluid (CSF) and plasma amyloid/tau/neurodegeneration biomarkers, and hippocampal volume. Results: In DS, BF volumes decreased with age and along the clinical AD continuum and significantly correlated with amyloid, tau, and neurofilament light chain changes in CSF and plasma, hippocampal volume, and cognitive performance. Discussion: BF atrophy is a potentially valuable neuroimaging biomarker of AD-related cholinergic neurodegeneration in DS.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/61249
http://dx.doi.org/10.1002/alz.12999
url http://hdl.handle.net/10230/61249
http://dx.doi.org/10.1002/alz.12999
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Alzheimers Dement. 2023 Nov;19(11):4817-27
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
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