Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case-Control Study in Spain and Italy
BACKGROUND: Evidence on the association between colorectal cancer and exposure to disinfection by-products in drinking water is inconsistent. OBJECTIVES: We assessed long-term exposure to trihalomethanes (THMs), the most prevalent group of chlorination by-products, to evaluate the association with c...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/160477 |
| Acesso em linha: | https://hdl.handle.net/2445/160477 |
| Access Level: | acceso abierto |
| Palavra-chave: | Càncer colorectal Aigua potable Espanya Itàlia Colorectal cancer Drinking water Spain Italy |
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Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case-Control Study in Spain and ItalyVillanueva, Cristina M.Gracia Lavedan, EstherBosetti, CristinaRighi, ElenaMolina de la Torre, Antonio JoséMartín Sánchez, VicenteBoldo, ElenaAragonès Sanz, NúriaPérez Gómez, BeatrizPollán, MarinaGómez Acebo, InésAltzibar, Jone M.Jiménez Zabala, AnaArdanaz, EvaPeiró Pérez, RosanaTardón, AdoninaChirlaque, María DoloresTavani, AlessandraPolesel, JerrySerraino, DiegoPisa, Federica E.Castaño-Vinyals, GemmaEspinosa Cardiel, AnaEspejo-Herrera, NadiaPalau, MargaritaMoreno Aguado, VíctorVecchia, Carlo LaAggazzotti, GabriellaNieuwenhuijsen, Mark J.Kogevinas, ManolisCàncer colorectalAigua potableEspanyaItàliaColorectal cancerDrinking waterSpainItalyBACKGROUND: Evidence on the association between colorectal cancer and exposure to disinfection by-products in drinking water is inconsistent. OBJECTIVES: We assessed long-term exposure to trihalomethanes (THMs), the most prevalent group of chlorination by-products, to evaluate the association with colorectal cancer. METHODS: A multicentre case-control study was conducted in Spain and Italy in 2008-2013. Hospital-based incident cases, population-based (Spain) and hospital-based (Italy) controls were interviewed to ascertain residential histories, water type consumed in each residence, frequency and duration of showering/ bathing, and major recognized risk factors for colorectal cancer. We estimated adjusted odds ratios (OR) for colorectal cancer in association with quartiles of estimated average lifetime THM concentrations in each participant's residential tap water (μg/L, from age 18 to two years before the interview) and estimated average lifetime THM ingestion from drinking residential tap water (μg/day). RESULTS: Subjects analyzed were 2047 cases and 3718 controls. Median values (ranges) for average lifetime residential tap water concentrations of total THMs, chloroform, and brominated THMs were 30 (0-174), 17 (0-63), and 9 (0-145) μg/L, respectively. Total THM concentration in residential tap water was not associated with colorectal cancer (OR=0.92, 95%CI: 0.66-1.28 for highest vs. lowest quartile), but chloroform concentrations were inversely associated (OR=0.31, 95%CI: 0.24-0.41 for highest vs. lowest quartile). Brominated THMs concentrations showed a positive association among men at the highest vs. lowest quartile (OR=1.43, 95%CI: 0.83-2.46). Patterns of associations were similar for estimated average THM ingestion through residential water consumption. CONCLUSIONS: We did not find clear evidence of an association between detailed estimates of lifetime total THM exposures and colorectal cancer in our large case-control study population. Negative associations with chloroform concentrations and ingestion suggest differences among specific THMs, but these findings need confirmation in other study populationsNational Institute of Environmental Health Science2020202020172020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/160477Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1289/EHP155Environmental Health Perspectives, 2017, vol. 125, num. 1, p. 56-65https://doi.org/10.1289/EHP155cc 0 (c) Villanueva, Cristina M. et al., 2017http://creativecommons.org/publicdomain/zero/1.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1604772026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case-Control Study in Spain and Italy |
| title |
Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case-Control Study in Spain and Italy |
| spellingShingle |
Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case-Control Study in Spain and Italy Villanueva, Cristina M. Càncer colorectal Aigua potable Espanya Itàlia Colorectal cancer Drinking water Spain Italy |
| title_short |
Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case-Control Study in Spain and Italy |
| title_full |
Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case-Control Study in Spain and Italy |
| title_fullStr |
Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case-Control Study in Spain and Italy |
| title_full_unstemmed |
Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case-Control Study in Spain and Italy |
| title_sort |
Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case-Control Study in Spain and Italy |
| dc.creator.none.fl_str_mv |
Villanueva, Cristina M. Gracia Lavedan, Esther Bosetti, Cristina Righi, Elena Molina de la Torre, Antonio José Martín Sánchez, Vicente Boldo, Elena Aragonès Sanz, Núria Pérez Gómez, Beatriz Pollán, Marina Gómez Acebo, Inés Altzibar, Jone M. Jiménez Zabala, Ana Ardanaz, Eva Peiró Pérez, Rosana Tardón, Adonina Chirlaque, María Dolores Tavani, Alessandra Polesel, Jerry Serraino, Diego Pisa, Federica E. Castaño-Vinyals, Gemma Espinosa Cardiel, Ana Espejo-Herrera, Nadia Palau, Margarita Moreno Aguado, Víctor Vecchia, Carlo La Aggazzotti, Gabriella Nieuwenhuijsen, Mark J. Kogevinas, Manolis |
| author |
Villanueva, Cristina M. |
| author_facet |
Villanueva, Cristina M. Gracia Lavedan, Esther Bosetti, Cristina Righi, Elena Molina de la Torre, Antonio José Martín Sánchez, Vicente Boldo, Elena Aragonès Sanz, Núria Pérez Gómez, Beatriz Pollán, Marina Gómez Acebo, Inés Altzibar, Jone M. Jiménez Zabala, Ana Ardanaz, Eva Peiró Pérez, Rosana Tardón, Adonina Chirlaque, María Dolores Tavani, Alessandra Polesel, Jerry Serraino, Diego Pisa, Federica E. Castaño-Vinyals, Gemma Espinosa Cardiel, Ana Espejo-Herrera, Nadia Palau, Margarita Moreno Aguado, Víctor Vecchia, Carlo La Aggazzotti, Gabriella Nieuwenhuijsen, Mark J. Kogevinas, Manolis |
| author_role |
author |
| author2 |
Gracia Lavedan, Esther Bosetti, Cristina Righi, Elena Molina de la Torre, Antonio José Martín Sánchez, Vicente Boldo, Elena Aragonès Sanz, Núria Pérez Gómez, Beatriz Pollán, Marina Gómez Acebo, Inés Altzibar, Jone M. Jiménez Zabala, Ana Ardanaz, Eva Peiró Pérez, Rosana Tardón, Adonina Chirlaque, María Dolores Tavani, Alessandra Polesel, Jerry Serraino, Diego Pisa, Federica E. Castaño-Vinyals, Gemma Espinosa Cardiel, Ana Espejo-Herrera, Nadia Palau, Margarita Moreno Aguado, Víctor Vecchia, Carlo La Aggazzotti, Gabriella Nieuwenhuijsen, Mark J. Kogevinas, Manolis |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Càncer colorectal Aigua potable Espanya Itàlia Colorectal cancer Drinking water Spain Italy |
| topic |
Càncer colorectal Aigua potable Espanya Itàlia Colorectal cancer Drinking water Spain Italy |
| description |
BACKGROUND: Evidence on the association between colorectal cancer and exposure to disinfection by-products in drinking water is inconsistent. OBJECTIVES: We assessed long-term exposure to trihalomethanes (THMs), the most prevalent group of chlorination by-products, to evaluate the association with colorectal cancer. METHODS: A multicentre case-control study was conducted in Spain and Italy in 2008-2013. Hospital-based incident cases, population-based (Spain) and hospital-based (Italy) controls were interviewed to ascertain residential histories, water type consumed in each residence, frequency and duration of showering/ bathing, and major recognized risk factors for colorectal cancer. We estimated adjusted odds ratios (OR) for colorectal cancer in association with quartiles of estimated average lifetime THM concentrations in each participant's residential tap water (μg/L, from age 18 to two years before the interview) and estimated average lifetime THM ingestion from drinking residential tap water (μg/day). RESULTS: Subjects analyzed were 2047 cases and 3718 controls. Median values (ranges) for average lifetime residential tap water concentrations of total THMs, chloroform, and brominated THMs were 30 (0-174), 17 (0-63), and 9 (0-145) μg/L, respectively. Total THM concentration in residential tap water was not associated with colorectal cancer (OR=0.92, 95%CI: 0.66-1.28 for highest vs. lowest quartile), but chloroform concentrations were inversely associated (OR=0.31, 95%CI: 0.24-0.41 for highest vs. lowest quartile). Brominated THMs concentrations showed a positive association among men at the highest vs. lowest quartile (OR=1.43, 95%CI: 0.83-2.46). Patterns of associations were similar for estimated average THM ingestion through residential water consumption. CONCLUSIONS: We did not find clear evidence of an association between detailed estimates of lifetime total THM exposures and colorectal cancer in our large case-control study population. Negative associations with chloroform concentrations and ingestion suggest differences among specific THMs, but these findings need confirmation in other study populations |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2020 2020 2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/160477 |
| url |
https://hdl.handle.net/2445/160477 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1289/EHP155 Environmental Health Perspectives, 2017, vol. 125, num. 1, p. 56-65 https://doi.org/10.1289/EHP155 |
| dc.rights.none.fl_str_mv |
cc 0 (c) Villanueva, Cristina M. et al., 2017 http://creativecommons.org/publicdomain/zero/1.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
cc 0 (c) Villanueva, Cristina M. et al., 2017 http://creativecommons.org/publicdomain/zero/1.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
10 p. application/pdf |
| dc.publisher.none.fl_str_mv |
National Institute of Environmental Health Science |
| publisher.none.fl_str_mv |
National Institute of Environmental Health Science |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Ciències Clíniques) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869407626768416768 |
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15,81155 |