Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration

Neuroinflammation involves the activation of glial cells and represents a key element in normal aging and pathophysiology of brain damage. N-acylethanolamides (NAEs), naturally occurring amides, are known for their pro-homeostatic effects. An increase in NAEs has been reported in vivo and in vitro i...

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Detalhes bibliográficos
Autores: Herrera, María Inés, Kölliker Frers, Rodolfo, Barreto, George, Blanco Calvo, Eduardo, Capani, Francisco
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2016
País:España
Recursos:Universitat de Lleida (UdL)
Repositório:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/57150
Acesso em linha:https://doi.org/10.3389/fnagi.2016.00081
http://hdl.handle.net/10459.1/57150
Access Level:Acceso aberto
Palavra-chave:Neuroinflammation
Gliosis
N-acylethanolamides
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spelling Glial Modulation by N-acylethanolamides in Brain Injury and NeurodegenerationHerrera, María InésKölliker Frers, RodolfoBarreto, GeorgeBlanco Calvo, EduardoCapani, FranciscoNeuroinflammationGliosisN-acylethanolamidesNeuroinflammation involves the activation of glial cells and represents a key element in normal aging and pathophysiology of brain damage. N-acylethanolamides (NAEs), naturally occurring amides, are known for their pro-homeostatic effects. An increase in NAEs has been reported in vivo and in vitro in the aging brain and in brain injury. Treatment with NAEs may promote neuroprotection and exert anti-inflammatory actions via PPARα activation and/or by counteracting gliosis. This review aims to provide an overview of endogenous and exogenous properties of NAEs in neuroinflammation and to discuss their interaction with glial cells.Frontiers Media2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3389/fnagi.2016.00081http://hdl.handle.net/10459.1/57150reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a https://doi.org/10.3389/fnagi.2016.00081Frontiers in Aging Neuroscience, 2016, vol. 8, núm. 81, p. 1-10cc-by (c) Herrera et al., 2016info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/oai:repositori.udl.cat:10459.1/571502026-06-24T12:42:17Z
dc.title.none.fl_str_mv Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration
title Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration
spellingShingle Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration
Herrera, María Inés
Neuroinflammation
Gliosis
N-acylethanolamides
title_short Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration
title_full Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration
title_fullStr Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration
title_full_unstemmed Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration
title_sort Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration
dc.creator.none.fl_str_mv Herrera, María Inés
Kölliker Frers, Rodolfo
Barreto, George
Blanco Calvo, Eduardo
Capani, Francisco
author Herrera, María Inés
author_facet Herrera, María Inés
Kölliker Frers, Rodolfo
Barreto, George
Blanco Calvo, Eduardo
Capani, Francisco
author_role author
author2 Kölliker Frers, Rodolfo
Barreto, George
Blanco Calvo, Eduardo
Capani, Francisco
author2_role author
author
author
author
dc.subject.none.fl_str_mv Neuroinflammation
Gliosis
N-acylethanolamides
topic Neuroinflammation
Gliosis
N-acylethanolamides
description Neuroinflammation involves the activation of glial cells and represents a key element in normal aging and pathophysiology of brain damage. N-acylethanolamides (NAEs), naturally occurring amides, are known for their pro-homeostatic effects. An increase in NAEs has been reported in vivo and in vitro in the aging brain and in brain injury. Treatment with NAEs may promote neuroprotection and exert anti-inflammatory actions via PPARα activation and/or by counteracting gliosis. This review aims to provide an overview of endogenous and exogenous properties of NAEs in neuroinflammation and to discuss their interaction with glial cells.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.3389/fnagi.2016.00081
http://hdl.handle.net/10459.1/57150
url https://doi.org/10.3389/fnagi.2016.00081
http://hdl.handle.net/10459.1/57150
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.3389/fnagi.2016.00081
Frontiers in Aging Neuroscience, 2016, vol. 8, núm. 81, p. 1-10
dc.rights.none.fl_str_mv cc-by (c) Herrera et al., 2016
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
rights_invalid_str_mv cc-by (c) Herrera et al., 2016
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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