Single-use impulsion system for displacement of liquids on thermoplastic-based lab on chip
In this paper, an impulsion system of liquids for thermoplastic microfluidic circuits is described. The presented device is composed of a membrane made of polymethylmethacrylate (PMMA) which separates two microchambers (top and bottom microchamber). The bottom microchamber is pressurized to a fixed...
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| Formato: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2019 |
| País: | España |
| Recursos: | Universidad de Sevilla (US) |
| Repositorio: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/166651 |
| Acesso em linha: | https://hdl.handle.net/11441/166651 https://doi.org/10.1016/j.sna.2019.111568 |
| Access Level: | acceso abierto |
| Palavra-chave: | Impulsion-system Thermoplastics Lab-on-chip Microfluidics |
| Resumo: | In this paper, an impulsion system of liquids for thermoplastic microfluidic circuits is described. The presented device is composed of a membrane made of polymethylmethacrylate (PMMA) which separates two microchambers (top and bottom microchamber). The bottom microchamber is pressurized to a fixed pressure, while the top microchamber remains at atmospheric pressure. The actuation consists on increasing the temperature of the membrane by Joule effect using an aluminum microheater which is fabricated over the membrane. Once the temperature of the membrane is close to the glass transition temperature of the thermoplastic, the membrane deforms due to the different pressure of the bottom microchamber, blocking the top microchamber. The trapped air fits the volume of liquid which will be impulsed inside the microchannel. Unlike other membranes used in microfluidics, the presented membrane keeps deformed when the actuation is removed. The fabricated impulsion system is designed to move a volume of 30 μL. The experimental results correspond to a theoretical design with an average error of about 6.32%. The proposed impulsion system is easily integrable on thermoplastic lab on chips for liquid management. |
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