Role of KLF6 as early predictor in human colorectal cancer | Papel de KLF6, como factor de predicción precoz en cáncer colorrectal humano

Colorectal cancer (CRC) is the second most common type of cancer in the European population. Currently there molecular biomarkers that can be used for early detection of cancer of CRC. Is a tumor suppressor KLF6 associated with several types of cancers. Our hypothesis is that KLF6 can be an excellen...

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Detalhes bibliográficos
Autores: Laime, Delia, Llanqui, Octavio, Juarranz de la Fuente, Ángeles, Luisa Botella, M., Ramírez-García, José Ramón, Sanz Rodríguez, Francisco
Formato: artículo
Fecha de publicación:2012
País:España
Recursos:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:español
OAI Identifier:oai:repositorio.uam.es:10486/663277
Acesso em linha:http://hdl.handle.net/10486/663277
https://dx.doi.org/10.4067/S0717-95022012000300058
Access Level:acceso abierto
Palavra-chave:Colon cancer
KLF6
Adenocarcinoma
Biología y Biomedicina / Biología
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spelling Role of KLF6 as early predictor in human colorectal cancer | Papel de KLF6, como factor de predicción precoz en cáncer colorrectal humanoLaime, DeliaLlanqui, OctavioJuarranz de la Fuente, ÁngelesLuisa Botella, M.Ramírez-García, José RamónSanz Rodríguez, FranciscoColon cancerKLF6AdenocarcinomaBiología y Biomedicina / BiologíaColorectal cancer (CRC) is the second most common type of cancer in the European population. Currently there molecular biomarkers that can be used for early detection of cancer of CRC. Is a tumor suppressor KLF6 associated with several types of cancers. Our hypothesis is that KLF6 can be an excellent marker for the early diagnosis of CRC. To study the implication of KLF6 in CRC, we selected 15 biopsies of each stage (T1, T2 and T3) from the archives of the Pathology Department of Defense Central Hospital Gómez-Ulla, which had areas of affected tissue (tumor) and unaffected areas (non-tumor). This study was performed histological, immunohistochemical and RT-PCR, based on the expression of three genes, markers Ki67 and p53 as positive and as a marker in KLF6 study. The results showed that the expression of KLF6 is directly related to increased malignancy cell adenocarcinomas, corroborated by RT-PCR, showing the gradual emergence of alternative forms processing, corresponding to no KLF6. This protein was expressed both cytoplasmic and nuclear in the early stages T1 and T2, disappearing at the nuclear level in the most advanced stage (T3). KLF6 conclude that a good CRC tumor marker because it shows patterns of expression level increased cytoplasmic and nuclear level decreasingEste trabajo fue financiado por: Universidad de Tarapacá, Departamento de Biología “Proyecto Mayor Código 1042", Arica, Chile; Universidad Autónoma de Madrid, Facultad de Ciencias, Depto. de Citología y Facultad de Medicina; y Hospital Central de la Defensa Gómez-Ulla, Servicio de Anatomía Patológica de Madrid, EspañaElsevier B.V.Departamento de BiologíaFacultad de Ciencias20122012-09-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/663277https://dx.doi.org/10.4067/S0717-95022012000300058reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridEspañolspaopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6632772026-06-23T12:46:27Z
dc.title.none.fl_str_mv Role of KLF6 as early predictor in human colorectal cancer | Papel de KLF6, como factor de predicción precoz en cáncer colorrectal humano
title Role of KLF6 as early predictor in human colorectal cancer | Papel de KLF6, como factor de predicción precoz en cáncer colorrectal humano
spellingShingle Role of KLF6 as early predictor in human colorectal cancer | Papel de KLF6, como factor de predicción precoz en cáncer colorrectal humano
Laime, Delia
Colon cancer
KLF6
Adenocarcinoma
Biología y Biomedicina / Biología
title_short Role of KLF6 as early predictor in human colorectal cancer | Papel de KLF6, como factor de predicción precoz en cáncer colorrectal humano
title_full Role of KLF6 as early predictor in human colorectal cancer | Papel de KLF6, como factor de predicción precoz en cáncer colorrectal humano
title_fullStr Role of KLF6 as early predictor in human colorectal cancer | Papel de KLF6, como factor de predicción precoz en cáncer colorrectal humano
title_full_unstemmed Role of KLF6 as early predictor in human colorectal cancer | Papel de KLF6, como factor de predicción precoz en cáncer colorrectal humano
title_sort Role of KLF6 as early predictor in human colorectal cancer | Papel de KLF6, como factor de predicción precoz en cáncer colorrectal humano
dc.creator.none.fl_str_mv Laime, Delia
Llanqui, Octavio
Juarranz de la Fuente, Ángeles
Luisa Botella, M.
Ramírez-García, José Ramón
Sanz Rodríguez, Francisco
author Laime, Delia
author_facet Laime, Delia
Llanqui, Octavio
Juarranz de la Fuente, Ángeles
Luisa Botella, M.
Ramírez-García, José Ramón
Sanz Rodríguez, Francisco
author_role author
author2 Llanqui, Octavio
Juarranz de la Fuente, Ángeles
Luisa Botella, M.
Ramírez-García, José Ramón
Sanz Rodríguez, Francisco
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Biología
Facultad de Ciencias
dc.subject.none.fl_str_mv Colon cancer
KLF6
Adenocarcinoma
Biología y Biomedicina / Biología
topic Colon cancer
KLF6
Adenocarcinoma
Biología y Biomedicina / Biología
description Colorectal cancer (CRC) is the second most common type of cancer in the European population. Currently there molecular biomarkers that can be used for early detection of cancer of CRC. Is a tumor suppressor KLF6 associated with several types of cancers. Our hypothesis is that KLF6 can be an excellent marker for the early diagnosis of CRC. To study the implication of KLF6 in CRC, we selected 15 biopsies of each stage (T1, T2 and T3) from the archives of the Pathology Department of Defense Central Hospital Gómez-Ulla, which had areas of affected tissue (tumor) and unaffected areas (non-tumor). This study was performed histological, immunohistochemical and RT-PCR, based on the expression of three genes, markers Ki67 and p53 as positive and as a marker in KLF6 study. The results showed that the expression of KLF6 is directly related to increased malignancy cell adenocarcinomas, corroborated by RT-PCR, showing the gradual emergence of alternative forms processing, corresponding to no KLF6. This protein was expressed both cytoplasmic and nuclear in the early stages T1 and T2, disappearing at the nuclear level in the most advanced stage (T3). KLF6 conclude that a good CRC tumor marker because it shows patterns of expression level increased cytoplasmic and nuclear level decreasing
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-09-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/663277
https://dx.doi.org/10.4067/S0717-95022012000300058
url http://hdl.handle.net/10486/663277
https://dx.doi.org/10.4067/S0717-95022012000300058
dc.language.none.fl_str_mv Español
spa
language_invalid_str_mv Español
language spa
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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