Pd2L4 Metal-Organic Cages with Perfluoroalkyl Edges: Ligand Design and Synthesis
[EN] Molecular cages are versatile supramolecular architectures with applications in guest encapsulation, catalysis, and sensing. This study reports the first Pd2L4 cage where vertices are bridged by-(CF2)n-chains. Cage synthesis is achieved by the self-assembly of a ligand comprising a perfluorinat...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | inglés |
| OAI Identifier: | oai:riunet.upv.es:10251/228465 |
| Acceso en línea: | https://riunet.upv.es/handle/10251/228465 |
| Access Level: | acceso abierto |
| Palabra clave: | Molecular cages Fluorous cages Supra-molecular chemistry Self-assembly Ligand design |
| Sumario: | [EN] Molecular cages are versatile supramolecular architectures with applications in guest encapsulation, catalysis, and sensing. This study reports the first Pd2L4 cage where vertices are bridged by-(CF2)n-chains. Cage synthesis is achieved by the self-assembly of a ligand comprising a perfluorinated alkyl chain grafted with terminal pyridines and Pd(II). While the synthesis with a ligand comprising alpha,omega-monosubstituted pyridines partially produces the desired cage, the further design of two ligands with methoxy groups at the meta or para positions relative to the N-atom greatly enhances the coordination strength between the metal centre and the pyridine group. The para-substituted ligand quantitatively yields the most stable Pd2L4 cage. These findings highlight the influence of electronic effects on coordination-driven self-assembly and provide a pathway for designing robust and functional metal-organic cages containing perfluorinated edges. Additionally, we performed host-guest experiments that show a good affinity with environmentally concerning contaminant perfluorooctanoic acid. In summary, we developed Pd2L4 metal-organic cages with perfluoroalkyl edges that show good stability and promising host-guest properties. |
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