TARTESSUS: A Customized Electrospun Drug Delivery System Loaded with Irinotecan for Local and Sustained Chemotherapy Release in Pancreatic Cancer

Post-surgical chemotherapy in pancreatic cancer has notorious side effects due to the high dose required. Multiple devices have been designed to tackle this aspect and achieve a delayed drug release. This study aimed to explore the controlled and sustained local delivery of a reduced drug dose from...

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Authors: Cepeda-Franco, C. (Carmen)|||/items/af2438ec-24d5-4a53-bca1-fe7c2e453e3f, Mitxelena-Iribarren, O. (Oihane)|||/items/2f0f7bf1-9f70-4341-b8e0-878b3a29a74c, Calero-Castro, F.J.(Francisco José)|||/items/fd7124ff-4ef0-45d1-874f-528cfbd91c5a, Astigarraga, M.(Malen)|||/items/b26e945d-5933-423d-a2be-f2717500af0c, Castillo-Tuñon, J.M.(Juan Manuel)|||/items/c2e02e2b-e938-41c7-b1fd-fbfb3e69b7d3, Laga, I. (Iman)|||/items/13724a9e-3536-41c1-b520-ecac6b087901, Pereira, S. (Sheila)|||/items/9d46952d-8a28-4989-bc03-171a6f012375, Arana-Alonso, S. (Sergio)|||/items/8923dfc6-4204-4ab9-8226-7b1b057a6c0e, Mujika-Garmendia, M. (Maite)|||/items/101efcb3-97d6-42c2-ac69-4c7d9a2ba06f, Padillo-Ruiz, J. (Javier)|||/items/a6c2dd7f-7d37-480e-9be3-78ee59b88ae7
Format: article
Publication Date:2023
Country:España
Institution:Universidad de Navarra
Repository:Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:English
OAI Identifier:oai:dadun.unav.edu:10171/68901
Online Access:https://hdl.handle.net/10171/68901
Access Level:Open access
Keyword:Electrospinning.
Nanofiber membrane.
Pancreatic cancer.
Drug delivery system.
Irinotecan.
Description
Summary:Post-surgical chemotherapy in pancreatic cancer has notorious side effects due to the high dose required. Multiple devices have been designed to tackle this aspect and achieve a delayed drug release. This study aimed to explore the controlled and sustained local delivery of a reduced drug dose from an irinotecan-loaded electrospun nanofiber membrane (named TARTESSUS) that can be placed on the patients' tissue after tumor resection surgery. The drug delivery system formulation was made of polycaprolactone (PCL)...

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