Modifications in the distribution of met-enkephalin in the cat spinal cord after administration of clonidine. An immunocytochemical study
We have studied the modifications in the distribution of methionine-enkephalin in the cat spinal cord after intravenous or intrathecal administration of clonidine by using an immunocytochemical technique. In animals not treated with the substance, a very high density of immunoreactive fibers was fou...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 1998 |
| País: | España |
| Institución: | Universidad de Sevilla (US) |
| Repositorio: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/58809 |
| Acceso en línea: | http://hdl.handle.net/11441/58809 |
| Access Level: | acceso abierto |
| Palabra clave: | Met-cnkephalin Clonidine Spinal cord Immunocytochemistry Cat |
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Modifications in the distribution of met-enkephalin in the cat spinal cord after administration of clonidine. An immunocytochemical studyVázquez Tapioles, JoséCoveñas Rodríguez, RafaelMuñoz Sáez, MiguelGarcía, J. A.Victoria, A.Met-cnkephalinClonidineSpinal cordImmunocytochemistryCatWe have studied the modifications in the distribution of methionine-enkephalin in the cat spinal cord after intravenous or intrathecal administration of clonidine by using an immunocytochemical technique. In animals not treated with the substance, a very high density of immunoreactive fibers was found in layers I and 11; a high density in the dorso-lateral funiculus and in the reticular formation; a moderate density in layers 111, IV and V; and a low density in layer VI. However, after intravenous or intrathecal administration of clonidine a decrease in fibers containing met-enkephalin was observed in layers I and I1 (high or moderate density), the dorso-lateral funiculus, and the reticular formation (moderate or low density), and in layers IV and V (low or very low density). In all cases, the decrease in the immunoreactivity was more marked when clonidine was administered intrathecally. Our results suggest that clonidine induces the release of metenkephalin in the spinal cord. They further suggest that the opioid peptide released could be involved in the control of nociceptive transmission by inhibiting the release of neurotransmitters (e.g., substance P). In summary, our study shows that clonidine could be involved in antinociceptive mechanisms in the cat spinal cord.Universidad de Murcia. Departamento de Biología Celular e HistologíaMedicinaBiología Celular1998info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/11441/58809reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésHistology and Histopathology, 13 (4), 955-959.info:eu-repo/semantics/openAccessoai:idus.us.es:11441/588092026-06-17T12:51:07Z |
| dc.title.none.fl_str_mv |
Modifications in the distribution of met-enkephalin in the cat spinal cord after administration of clonidine. An immunocytochemical study |
| title |
Modifications in the distribution of met-enkephalin in the cat spinal cord after administration of clonidine. An immunocytochemical study |
| spellingShingle |
Modifications in the distribution of met-enkephalin in the cat spinal cord after administration of clonidine. An immunocytochemical study Vázquez Tapioles, José Met-cnkephalin Clonidine Spinal cord Immunocytochemistry Cat |
| title_short |
Modifications in the distribution of met-enkephalin in the cat spinal cord after administration of clonidine. An immunocytochemical study |
| title_full |
Modifications in the distribution of met-enkephalin in the cat spinal cord after administration of clonidine. An immunocytochemical study |
| title_fullStr |
Modifications in the distribution of met-enkephalin in the cat spinal cord after administration of clonidine. An immunocytochemical study |
| title_full_unstemmed |
Modifications in the distribution of met-enkephalin in the cat spinal cord after administration of clonidine. An immunocytochemical study |
| title_sort |
Modifications in the distribution of met-enkephalin in the cat spinal cord after administration of clonidine. An immunocytochemical study |
| dc.creator.none.fl_str_mv |
Vázquez Tapioles, José Coveñas Rodríguez, Rafael Muñoz Sáez, Miguel García, J. A. Victoria, A. |
| author |
Vázquez Tapioles, José |
| author_facet |
Vázquez Tapioles, José Coveñas Rodríguez, Rafael Muñoz Sáez, Miguel García, J. A. Victoria, A. |
| author_role |
author |
| author2 |
Coveñas Rodríguez, Rafael Muñoz Sáez, Miguel García, J. A. Victoria, A. |
| author2_role |
author author author author |
| dc.contributor.none.fl_str_mv |
Medicina Biología Celular |
| dc.subject.none.fl_str_mv |
Met-cnkephalin Clonidine Spinal cord Immunocytochemistry Cat |
| topic |
Met-cnkephalin Clonidine Spinal cord Immunocytochemistry Cat |
| description |
We have studied the modifications in the distribution of methionine-enkephalin in the cat spinal cord after intravenous or intrathecal administration of clonidine by using an immunocytochemical technique. In animals not treated with the substance, a very high density of immunoreactive fibers was found in layers I and 11; a high density in the dorso-lateral funiculus and in the reticular formation; a moderate density in layers 111, IV and V; and a low density in layer VI. However, after intravenous or intrathecal administration of clonidine a decrease in fibers containing met-enkephalin was observed in layers I and I1 (high or moderate density), the dorso-lateral funiculus, and the reticular formation (moderate or low density), and in layers IV and V (low or very low density). In all cases, the decrease in the immunoreactivity was more marked when clonidine was administered intrathecally. Our results suggest that clonidine induces the release of metenkephalin in the spinal cord. They further suggest that the opioid peptide released could be involved in the control of nociceptive transmission by inhibiting the release of neurotransmitters (e.g., substance P). In summary, our study shows that clonidine could be involved in antinociceptive mechanisms in the cat spinal cord. |
| publishDate |
1998 |
| dc.date.none.fl_str_mv |
1998 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11441/58809 |
| url |
http://hdl.handle.net/11441/58809 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Histology and Histopathology, 13 (4), 955-959. |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Universidad de Murcia. Departamento de Biología Celular e Histología |
| publisher.none.fl_str_mv |
Universidad de Murcia. Departamento de Biología Celular e Histología |
| dc.source.none.fl_str_mv |
reponame:idUS. Depósito de Investigación de la Universidad de Sevilla instname:Universidad de Sevilla (US) |
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Universidad de Sevilla (US) |
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idUS. Depósito de Investigación de la Universidad de Sevilla |
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idUS. Depósito de Investigación de la Universidad de Sevilla |
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1869407610034192384 |
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15,301603 |