Double positivity for HPV-DNA/p16(ink4a) is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patients

Background: The etiologic role of human papillomaviruses (HPV) in oropharyngeal cancer (OPC) is well established. Nevertheless, information on survival differences by anatomic sub-site or treatment remains scarce, and it is still unclear the HPV-relatedness definition with best diagnostic accuracy a...

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Autores: Mena Cervigón, Marisa, Taberna, Miren, Tous, Sara, Clavero, Omar, Quiros, Beatriz, Lloveras Rubio, Betlem, Alejo, Maria, Leon, Xavier, Quer, Miquel, Bague, Silvia, Mesía Nin, Ricard, Nogues, Julio, Gomà, Montse, Aguilà, Anton, Bonfill, Teresa, Blazquez, Carmen, Guix, Marta, Hijano, Rafael, Torres, Montserrat, Holzinger, Dana, Pawlita, Michael, Pavón Ribas, Miquel Àngel, Bravo, Ignacio G., Sanjosé Llongueras, Silvia de, Bosch José, Francesc Xavier, 1947-, Alemany i Vilches, Laia, Marquez, Sandra
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/172839
Acceso en línea:https://hdl.handle.net/2445/172839
Access Level:acceso abierto
Palabra clave:Papil·lomavirus
Càncer de boca
Papillomaviruses
Mouth cancer
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repository_id_str
spelling Double positivity for HPV-DNA/p16(ink4a) is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patientsMena Cervigón, MarisaTaberna, MirenTous, SaraClavero, OmarQuiros, BeatrizLloveras Rubio, BetlemAlejo, MariaLeon, XavierQuer, MiquelBague, SilviaMesía Nin, RicardNogues, JulioGomà, MontseAguilà, AntonBonfill, TeresaBlazquez, CarmenGuix, MartaHijano, RafaelTorres, MontserratHolzinger, DanaPawlita, MichaelPavón Ribas, Miquel ÀngelBravo, Ignacio G.Sanjosé Llongueras, Silvia deBosch José, Francesc Xavier, 1947-Alemany i Vilches, LaiaMarquez, SandraPapil·lomavirusCàncer de bocaPapillomavirusesMouth cancerBackground: The etiologic role of human papillomaviruses (HPV) in oropharyngeal cancer (OPC) is well established. Nevertheless, information on survival differences by anatomic sub-site or treatment remains scarce, and it is still unclear the HPV-relatedness definition with best diagnostic accuracy and prognostic value. Methods: We conducted a retrospective cohort study of all patients diagnosed with a primary OPC in four Catalonian hospitals from 1990 to 2013. Formalin-fixed, paraffin-embedded cancer tissues were subjected to histopathological evaluation, DNA quality control, HPV-DNA detection, and p16(INK4a)/pRb/p53/Cyclin-D1 immunohistochemistry. HPV-DNA positive and a random sample of HPV-DNA negative cases were subjected to HPV-E6*I mRNA detection. Demographic, tobacco/alcohol use, clinical and follow-up data were collected. Multivariate models were used to evaluate factors associated with HPV positivity as defined by four different HPV-relatedness definitions. Proportional-hazards models were used to compare the risk of death and recurrence among HPV-related and non-related OPC. Results: 788 patients yielded a valid HPV-DNA result. The percentage of positive cases was 10.9%, 10.2%, 8.5% and 7.4% for p16(INK4a), HPV-DNA, HPV-DNA/HPV-E6*I mRNA, and HPV-DNA/p16(INK4a), respectively. Being nonsmoker or non-drinker was consistently associated across HPV-relatedness definitions with HPV positivity. A suggestion of survival differences between anatomic sub-sites and treatments was observed. Double positivity for HPV-DNA/p16(INK4a) showed strongest diagnostic accuracy and prognostic value. Conclusions: Double positivity for HPV-DNA/p16(INK4a), a test that can be easily implemented in the clinical practice, has optimal diagnostic accuracy and prognostic value. Our results have strong clinical implications for patients' classification and handling and also suggest that not all the HPV-related OPC behave similarly.Elsevier Science Bv2020202020182020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion43 p.application/pdfhttps://hdl.handle.net/2445/172839Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.oraloncology.2018.01.010Oral Oncology, 2018, vol. 78, p. 137-144https://doi.org/10.1016/j.oraloncology.2018.01.010(c) Elsevier Science Bv, 2018info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1728392026-05-29T05:05:01Z
dc.title.none.fl_str_mv Double positivity for HPV-DNA/p16(ink4a) is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patients
title Double positivity for HPV-DNA/p16(ink4a) is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patients
spellingShingle Double positivity for HPV-DNA/p16(ink4a) is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patients
Mena Cervigón, Marisa
Papil·lomavirus
Càncer de boca
Papillomaviruses
Mouth cancer
title_short Double positivity for HPV-DNA/p16(ink4a) is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patients
title_full Double positivity for HPV-DNA/p16(ink4a) is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patients
title_fullStr Double positivity for HPV-DNA/p16(ink4a) is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patients
title_full_unstemmed Double positivity for HPV-DNA/p16(ink4a) is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patients
title_sort Double positivity for HPV-DNA/p16(ink4a) is the biomarker with strongest diagnostic accuracy and prognostic value for human papillomavirus related oropharyngeal cancer patients
dc.creator.none.fl_str_mv Mena Cervigón, Marisa
Taberna, Miren
Tous, Sara
Clavero, Omar
Quiros, Beatriz
Lloveras Rubio, Betlem
Alejo, Maria
Leon, Xavier
Quer, Miquel
Bague, Silvia
Mesía Nin, Ricard
Nogues, Julio
Gomà, Montse
Aguilà, Anton
Bonfill, Teresa
Blazquez, Carmen
Guix, Marta
Hijano, Rafael
Torres, Montserrat
Holzinger, Dana
Pawlita, Michael
Pavón Ribas, Miquel Àngel
Bravo, Ignacio G.
Sanjosé Llongueras, Silvia de
Bosch José, Francesc Xavier, 1947-
Alemany i Vilches, Laia
Marquez, Sandra
author Mena Cervigón, Marisa
author_facet Mena Cervigón, Marisa
Taberna, Miren
Tous, Sara
Clavero, Omar
Quiros, Beatriz
Lloveras Rubio, Betlem
Alejo, Maria
Leon, Xavier
Quer, Miquel
Bague, Silvia
Mesía Nin, Ricard
Nogues, Julio
Gomà, Montse
Aguilà, Anton
Bonfill, Teresa
Blazquez, Carmen
Guix, Marta
Hijano, Rafael
Torres, Montserrat
Holzinger, Dana
Pawlita, Michael
Pavón Ribas, Miquel Àngel
Bravo, Ignacio G.
Sanjosé Llongueras, Silvia de
Bosch José, Francesc Xavier, 1947-
Alemany i Vilches, Laia
Marquez, Sandra
author_role author
author2 Taberna, Miren
Tous, Sara
Clavero, Omar
Quiros, Beatriz
Lloveras Rubio, Betlem
Alejo, Maria
Leon, Xavier
Quer, Miquel
Bague, Silvia
Mesía Nin, Ricard
Nogues, Julio
Gomà, Montse
Aguilà, Anton
Bonfill, Teresa
Blazquez, Carmen
Guix, Marta
Hijano, Rafael
Torres, Montserrat
Holzinger, Dana
Pawlita, Michael
Pavón Ribas, Miquel Àngel
Bravo, Ignacio G.
Sanjosé Llongueras, Silvia de
Bosch José, Francesc Xavier, 1947-
Alemany i Vilches, Laia
Marquez, Sandra
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Papil·lomavirus
Càncer de boca
Papillomaviruses
Mouth cancer
topic Papil·lomavirus
Càncer de boca
Papillomaviruses
Mouth cancer
description Background: The etiologic role of human papillomaviruses (HPV) in oropharyngeal cancer (OPC) is well established. Nevertheless, information on survival differences by anatomic sub-site or treatment remains scarce, and it is still unclear the HPV-relatedness definition with best diagnostic accuracy and prognostic value. Methods: We conducted a retrospective cohort study of all patients diagnosed with a primary OPC in four Catalonian hospitals from 1990 to 2013. Formalin-fixed, paraffin-embedded cancer tissues were subjected to histopathological evaluation, DNA quality control, HPV-DNA detection, and p16(INK4a)/pRb/p53/Cyclin-D1 immunohistochemistry. HPV-DNA positive and a random sample of HPV-DNA negative cases were subjected to HPV-E6*I mRNA detection. Demographic, tobacco/alcohol use, clinical and follow-up data were collected. Multivariate models were used to evaluate factors associated with HPV positivity as defined by four different HPV-relatedness definitions. Proportional-hazards models were used to compare the risk of death and recurrence among HPV-related and non-related OPC. Results: 788 patients yielded a valid HPV-DNA result. The percentage of positive cases was 10.9%, 10.2%, 8.5% and 7.4% for p16(INK4a), HPV-DNA, HPV-DNA/HPV-E6*I mRNA, and HPV-DNA/p16(INK4a), respectively. Being nonsmoker or non-drinker was consistently associated across HPV-relatedness definitions with HPV positivity. A suggestion of survival differences between anatomic sub-sites and treatments was observed. Double positivity for HPV-DNA/p16(INK4a) showed strongest diagnostic accuracy and prognostic value. Conclusions: Double positivity for HPV-DNA/p16(INK4a), a test that can be easily implemented in the clinical practice, has optimal diagnostic accuracy and prognostic value. Our results have strong clinical implications for patients' classification and handling and also suggest that not all the HPV-related OPC behave similarly.
publishDate 2018
dc.date.none.fl_str_mv 2018
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/172839
url https://hdl.handle.net/2445/172839
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.oraloncology.2018.01.010
Oral Oncology, 2018, vol. 78, p. 137-144
https://doi.org/10.1016/j.oraloncology.2018.01.010
dc.rights.none.fl_str_mv (c) Elsevier Science Bv, 2018
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Elsevier Science Bv, 2018
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 43 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Bv
publisher.none.fl_str_mv Elsevier Science Bv
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,808905

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