Effect of Protection Polymer Coatings on the Performance of an Amperometric Galactose Biosensor in Human Plasma

© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

Bibliographic Details
Authors: Figueiredo, Carina, Psotta, Carolin, Jayakumar, Kavita, Lielpetere, Anna, Mandal, Tanushree, Schuhmann, Wolfgang, Leech, Dónal, Falk, Magnus, Pita, Marcos, Shleev, Sergey, López de Lacey, Antonio
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/355781
Online Access:http://hdl.handle.net/10261/355781
Access Level:Open access
Keyword:Galactose
Biosensor
Plasma
Protection polymers
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spelling Effect of Protection Polymer Coatings on the Performance of an Amperometric Galactose Biosensor in Human PlasmaFigueiredo, CarinaPsotta, CarolinJayakumar, KavitaLielpetere, AnnaMandal, TanushreeSchuhmann, WolfgangLeech, DónalFalk, MagnusPita, MarcosShleev, SergeyLópez de Lacey, AntonioGalactoseBiosensorPlasmaProtection polymers© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Galactose monitoring in individuals allows the prevention of harsh health conditions related to hereditary metabolic diseases like galactosemia. Current methods of galactose detection need development to obtain cheaper, more reliable, and more specific sensors. Enzyme-containing amperometric sensors based on galactose oxidase activity are a promising approach, which can be enhanced by means of their inclusion in a redox polymer coating. This strategy simultaneously allows the immobilization of the biocatalyst to the electroactive surface and hosts the electron shuttling units. An additional deposition of capping polymers prevents external interferences like ascorbic or uric acid as well as biofouling when measuring in physiological fuels. This work studies the protection effect of poly(2-methacryloyloxyethyl phosphorylcholine-co-glycidyl methacrylate (MPC) and polyvinylimidazole-polysulfostyrene (P(VI-SS)) when incorporated in the biosensor design for the detection of galactose in human plasma.This work was funded by the European Union’s Horizon 2020 research and innovation MSCA ITN program under grant agreement Nº 813006, IMPLANTSENS.Peer reviewedMultidisciplinary Digital Publishing InstituteEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2024202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/355781reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/813006The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.3390/bios14040167https://doi.org/10.3390/bios14040167Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3557812026-05-22T06:33:51Z
dc.title.none.fl_str_mv Effect of Protection Polymer Coatings on the Performance of an Amperometric Galactose Biosensor in Human Plasma
title Effect of Protection Polymer Coatings on the Performance of an Amperometric Galactose Biosensor in Human Plasma
spellingShingle Effect of Protection Polymer Coatings on the Performance of an Amperometric Galactose Biosensor in Human Plasma
Figueiredo, Carina
Galactose
Biosensor
Plasma
Protection polymers
title_short Effect of Protection Polymer Coatings on the Performance of an Amperometric Galactose Biosensor in Human Plasma
title_full Effect of Protection Polymer Coatings on the Performance of an Amperometric Galactose Biosensor in Human Plasma
title_fullStr Effect of Protection Polymer Coatings on the Performance of an Amperometric Galactose Biosensor in Human Plasma
title_full_unstemmed Effect of Protection Polymer Coatings on the Performance of an Amperometric Galactose Biosensor in Human Plasma
title_sort Effect of Protection Polymer Coatings on the Performance of an Amperometric Galactose Biosensor in Human Plasma
dc.creator.none.fl_str_mv Figueiredo, Carina
Psotta, Carolin
Jayakumar, Kavita
Lielpetere, Anna
Mandal, Tanushree
Schuhmann, Wolfgang
Leech, Dónal
Falk, Magnus
Pita, Marcos
Shleev, Sergey
López de Lacey, Antonio
author Figueiredo, Carina
author_facet Figueiredo, Carina
Psotta, Carolin
Jayakumar, Kavita
Lielpetere, Anna
Mandal, Tanushree
Schuhmann, Wolfgang
Leech, Dónal
Falk, Magnus
Pita, Marcos
Shleev, Sergey
López de Lacey, Antonio
author_role author
author2 Psotta, Carolin
Jayakumar, Kavita
Lielpetere, Anna
Mandal, Tanushree
Schuhmann, Wolfgang
Leech, Dónal
Falk, Magnus
Pita, Marcos
Shleev, Sergey
López de Lacey, Antonio
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Galactose
Biosensor
Plasma
Protection polymers
topic Galactose
Biosensor
Plasma
Protection polymers
description © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/355781
url http://hdl.handle.net/10261/355781
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/813006
The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.3390/bios14040167
https://doi.org/10.3390/bios14040167
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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