Nutrigenomics of the Mediterranean Diet: Gene–Diet Interactions and Bioactive Compounds in Cardiovascular Health

ABSTRACT The growing field of nutrigenomics explores the interaction between genetic makeup and dietary factors, particularly in the context of cardiovascular health. As cardiovascular diseases (CVDs) remain the leading cause of mortality globally, there is a need to better understand how individual...

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Authors: Ramírez‐Alarcón, Karina, Labraña, Ana María, Carrasco‐Marín, Fernanda, Benítez‐Cid, Pilar, Zapata‐Lamana, Rafael, Capó Fiol, Xavier, Monserrat Mesquida, Margalida, Sureda, Antoni, Contreras, Héctor, Valenzuela‐Mella, Francisca, Bravo, Daniel Pacheco, Calina, Daniela, Cádiz‐Gurrea, Maria de la Luz, Segura‐Carretero, Antonio, Setzer, William N., Sharifi‐Rad, Javad, Martorell, Miquel
Format: article
Publication Date:2026
Country:España
Institution:Conselleria de Salut i Consum del Govern de les Illes Balears
Repository:Docusalut
Language:English
OAI Identifier:oai:dnet:docusalut___::b0fb765dd6514bd315d5c36958ecc132
Online Access:https://hdl.handle.net/20.500.13003/27168
Access Level:Open access
Keyword:bioactive compounds
cardiovascular disease
genetic variations
inflammation
Mediterranean diet
nutrigenomics
oxidative stress
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spelling Nutrigenomics of the Mediterranean Diet: Gene–Diet Interactions and Bioactive Compounds in Cardiovascular HealthRamírez‐Alarcón, KarinaLabraña, Ana MaríaCarrasco‐Marín, FernandaBenítez‐Cid, PilarZapata‐Lamana, RafaelCapó Fiol, XavierMonserrat Mesquida, MargalidaSureda, AntoniContreras, HéctorValenzuela‐Mella, FranciscaBravo, Daniel PachecoCalina, DanielaCádiz‐Gurrea, Maria de la LuzSegura‐Carretero, AntonioSetzer, William N.Sharifi‐Rad, JavadMartorell, Miquelbioactive compoundscardiovascular diseasegenetic variationsinflammationMediterranean dietnutrigenomicsoxidative stressABSTRACT The growing field of nutrigenomics explores the interaction between genetic makeup and dietary factors, particularly in the context of cardiovascular health. As cardiovascular diseases (CVDs) remain the leading cause of mortality globally, there is a need to better understand how individual genetic variations influence dietary responses. The Mediterranean diet (MedDiet), rich in bioactive compounds such as polyphenols, omega‐3 fatty acids, and monounsaturated fats, has been widely studied for its cardioprotective effects. Recent advances in omics technologies have provided new insights into the molecular mechanisms underlying the benefits of the MedDiet. This narrative review focuses on the intersection of nutrigenomics and cardiovascular health, examining how the MedDiet influences gene expression and metabolic pathways, particularly those related to inflammation, oxidative stress, and lipid metabolism. It also discusses the role of specific nutrients and bioactive compounds in modulating gene expression and their potential to reduce CVD risk. Furthermore, the review explores how personalized nutrition, guided by genetic information, could enhance the efficacy of dietary interventions for CVD prevention and management. Although significant progress has been made in understanding gene–diet interactions, further research is needed to refine individualized dietary guidelines and integrate multi‐omics approaches for improved cardiovascular health outcomes.Wiley20262026-02-2820262026-02-28research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/27168reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:dnet:docusalut___::b0fb765dd6514bd315d5c36958ecc1322026-06-22T12:44:07Z
dc.title.none.fl_str_mv Nutrigenomics of the Mediterranean Diet: Gene–Diet Interactions and Bioactive Compounds in Cardiovascular Health
title Nutrigenomics of the Mediterranean Diet: Gene–Diet Interactions and Bioactive Compounds in Cardiovascular Health
spellingShingle Nutrigenomics of the Mediterranean Diet: Gene–Diet Interactions and Bioactive Compounds in Cardiovascular Health
Ramírez‐Alarcón, Karina
bioactive compounds
cardiovascular disease
genetic variations
inflammation
Mediterranean diet
nutrigenomics
oxidative stress
title_short Nutrigenomics of the Mediterranean Diet: Gene–Diet Interactions and Bioactive Compounds in Cardiovascular Health
title_full Nutrigenomics of the Mediterranean Diet: Gene–Diet Interactions and Bioactive Compounds in Cardiovascular Health
title_fullStr Nutrigenomics of the Mediterranean Diet: Gene–Diet Interactions and Bioactive Compounds in Cardiovascular Health
title_full_unstemmed Nutrigenomics of the Mediterranean Diet: Gene–Diet Interactions and Bioactive Compounds in Cardiovascular Health
title_sort Nutrigenomics of the Mediterranean Diet: Gene–Diet Interactions and Bioactive Compounds in Cardiovascular Health
dc.creator.none.fl_str_mv Ramírez‐Alarcón, Karina
Labraña, Ana María
Carrasco‐Marín, Fernanda
Benítez‐Cid, Pilar
Zapata‐Lamana, Rafael
Capó Fiol, Xavier
Monserrat Mesquida, Margalida
Sureda, Antoni
Contreras, Héctor
Valenzuela‐Mella, Francisca
Bravo, Daniel Pacheco
Calina, Daniela
Cádiz‐Gurrea, Maria de la Luz
Segura‐Carretero, Antonio
Setzer, William N.
Sharifi‐Rad, Javad
Martorell, Miquel
author Ramírez‐Alarcón, Karina
author_facet Ramírez‐Alarcón, Karina
Labraña, Ana María
Carrasco‐Marín, Fernanda
Benítez‐Cid, Pilar
Zapata‐Lamana, Rafael
Capó Fiol, Xavier
Monserrat Mesquida, Margalida
Sureda, Antoni
Contreras, Héctor
Valenzuela‐Mella, Francisca
Bravo, Daniel Pacheco
Calina, Daniela
Cádiz‐Gurrea, Maria de la Luz
Segura‐Carretero, Antonio
Setzer, William N.
Sharifi‐Rad, Javad
Martorell, Miquel
author_role author
author2 Labraña, Ana María
Carrasco‐Marín, Fernanda
Benítez‐Cid, Pilar
Zapata‐Lamana, Rafael
Capó Fiol, Xavier
Monserrat Mesquida, Margalida
Sureda, Antoni
Contreras, Héctor
Valenzuela‐Mella, Francisca
Bravo, Daniel Pacheco
Calina, Daniela
Cádiz‐Gurrea, Maria de la Luz
Segura‐Carretero, Antonio
Setzer, William N.
Sharifi‐Rad, Javad
Martorell, Miquel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv bioactive compounds
cardiovascular disease
genetic variations
inflammation
Mediterranean diet
nutrigenomics
oxidative stress
topic bioactive compounds
cardiovascular disease
genetic variations
inflammation
Mediterranean diet
nutrigenomics
oxidative stress
description ABSTRACT The growing field of nutrigenomics explores the interaction between genetic makeup and dietary factors, particularly in the context of cardiovascular health. As cardiovascular diseases (CVDs) remain the leading cause of mortality globally, there is a need to better understand how individual genetic variations influence dietary responses. The Mediterranean diet (MedDiet), rich in bioactive compounds such as polyphenols, omega‐3 fatty acids, and monounsaturated fats, has been widely studied for its cardioprotective effects. Recent advances in omics technologies have provided new insights into the molecular mechanisms underlying the benefits of the MedDiet. This narrative review focuses on the intersection of nutrigenomics and cardiovascular health, examining how the MedDiet influences gene expression and metabolic pathways, particularly those related to inflammation, oxidative stress, and lipid metabolism. It also discusses the role of specific nutrients and bioactive compounds in modulating gene expression and their potential to reduce CVD risk. Furthermore, the review explores how personalized nutrition, guided by genetic information, could enhance the efficacy of dietary interventions for CVD prevention and management. Although significant progress has been made in understanding gene–diet interactions, further research is needed to refine individualized dietary guidelines and integrate multi‐omics approaches for improved cardiovascular health outcomes.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026-02-28
2026
2026-02-28
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/27168
url https://hdl.handle.net/20.500.13003/27168
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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