Non-specific effects of inactivated Mycobacterium bovis oral and parenteral treatment in a rabbit scabies model

15 páginas, 1 tabla, 7 figuras.

Detalles Bibliográficos
Autores: Casais, Rosa, Iglesias, Natalia, Sevilla, Iker A, Garrido, Joseba M, Balseiro, Ana, Dominguez, Mercedes, Juste, Ramon A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/365685
Acceso en línea:http://hdl.handle.net/10261/365685
https://api.elsevier.com/content/abstract/scopus_id/85189269323
Access Level:acceso abierto
Palabra clave:Mycobacterium bovis
Sarcoptes scabiei
Killed vaccine
Scabies
Serology
Trained immunity
Tuberculosis
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
Protect, restore and promote sustainable use of terrestrial ecosystems, sustainably manage forests, combat desertification, and halt and reverse land degradation and halt biodiversity loss
tuberculosis
inactivated vaccines
scabies
serology
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repository_id_str
spelling Non-specific effects of inactivated Mycobacterium bovis oral and parenteral treatment in a rabbit scabies modelCasais, RosaIglesias, NataliaSevilla, Iker AGarrido, Joseba MBalseiro, AnaDominguez, MercedesJuste, Ramon AMycobacterium bovisSarcoptes scabieiKilled vaccineScabiesSerologyTrained immunityTuberculosishttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesProtect, restore and promote sustainable use of terrestrial ecosystems, sustainably manage forests, combat desertification, and halt and reverse land degradation and halt biodiversity losstuberculosisMycobacterium bovisSarcoptes scabieiinactivated vaccinesscabiesserology15 páginas, 1 tabla, 7 figuras.Tuberculosis BCG vaccination induced non-specific protective effects in humans led to postulate the concept of trained immunity (TRAIM) as an innate type of immune mechanism that triggered by a pathogen, protects against others. Killed vaccines have been considered not to be effective. However, field efficacy of a commercial vaccine against paratuberculosis, as well as of a recently developed M. bovis heat-inactivated vaccine (HIMB) prompted to test whether it could also induce TRAIM. To this, we used a sarcoptic mange rabbit model. Twenty-four weaned rabbits were treated orally or subcutaneously with a suspension of either HIMB (107 UFC) or placebo. Eighty-four days later the animals were challenged with approximately 5000 S. scabiei mites on the left hind limb. Skin lesion extension was measured every 2 weeks until 92 days post-infection (dpi). Two animals were killed at 77 dpi because of extensive skin damage. The rest were euthanized and necropsied and the lesion area and the mite burden per squared cm were estimated. Specific humoral immune responses to S. scabiei and to M. bovis were investigated with the corresponding specific ELISA tests. Subcutaneously and orally HIMB vaccinated animals compared with placebo showed reduced lesion scores (up to 74% and 62%, respectively) and mite counts (-170% and 39%, respectively). This, together with a significant positive correlation (r = 0.6276, p = 0.0031) between tuberculosis-specific antibodies and mite count at 92 dpi supported the hypothesis of non-specific effects of killed mycobacterial vaccination. Further research is needed to better understand this mechanism to maximize cross protection.Gobierno del Principado de Asturias, Regional funds PCTI 2021-2023 (GRUPIN: IDI2021-000102) co-funded by FEDER.Peer reviewedBioMed CentralPrincipado de AsturiasEuropean CommissionBalseiro Morales, Ana María [0000-0002-5121-7264]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/365685https://api.elsevier.com/content/abstract/scopus_id/85189269323reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésVeterinary researchhttp://dx.doi.org/doi.org/10.1186/s13567-024-01293-ySíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3656852026-05-22T06:33:51Z
dc.title.none.fl_str_mv Non-specific effects of inactivated Mycobacterium bovis oral and parenteral treatment in a rabbit scabies model
title Non-specific effects of inactivated Mycobacterium bovis oral and parenteral treatment in a rabbit scabies model
spellingShingle Non-specific effects of inactivated Mycobacterium bovis oral and parenteral treatment in a rabbit scabies model
Casais, Rosa
Mycobacterium bovis
Sarcoptes scabiei
Killed vaccine
Scabies
Serology
Trained immunity
Tuberculosis
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
Protect, restore and promote sustainable use of terrestrial ecosystems, sustainably manage forests, combat desertification, and halt and reverse land degradation and halt biodiversity loss
tuberculosis
Mycobacterium bovis
Sarcoptes scabiei
inactivated vaccines
scabies
serology
title_short Non-specific effects of inactivated Mycobacterium bovis oral and parenteral treatment in a rabbit scabies model
title_full Non-specific effects of inactivated Mycobacterium bovis oral and parenteral treatment in a rabbit scabies model
title_fullStr Non-specific effects of inactivated Mycobacterium bovis oral and parenteral treatment in a rabbit scabies model
title_full_unstemmed Non-specific effects of inactivated Mycobacterium bovis oral and parenteral treatment in a rabbit scabies model
title_sort Non-specific effects of inactivated Mycobacterium bovis oral and parenteral treatment in a rabbit scabies model
dc.creator.none.fl_str_mv Casais, Rosa
Iglesias, Natalia
Sevilla, Iker A
Garrido, Joseba M
Balseiro, Ana
Dominguez, Mercedes
Juste, Ramon A
author Casais, Rosa
author_facet Casais, Rosa
Iglesias, Natalia
Sevilla, Iker A
Garrido, Joseba M
Balseiro, Ana
Dominguez, Mercedes
Juste, Ramon A
author_role author
author2 Iglesias, Natalia
Sevilla, Iker A
Garrido, Joseba M
Balseiro, Ana
Dominguez, Mercedes
Juste, Ramon A
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Principado de Asturias
European Commission
Balseiro Morales, Ana María [0000-0002-5121-7264]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Mycobacterium bovis
Sarcoptes scabiei
Killed vaccine
Scabies
Serology
Trained immunity
Tuberculosis
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
Protect, restore and promote sustainable use of terrestrial ecosystems, sustainably manage forests, combat desertification, and halt and reverse land degradation and halt biodiversity loss
tuberculosis
Mycobacterium bovis
Sarcoptes scabiei
inactivated vaccines
scabies
serology
topic Mycobacterium bovis
Sarcoptes scabiei
Killed vaccine
Scabies
Serology
Trained immunity
Tuberculosis
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
Protect, restore and promote sustainable use of terrestrial ecosystems, sustainably manage forests, combat desertification, and halt and reverse land degradation and halt biodiversity loss
tuberculosis
Mycobacterium bovis
Sarcoptes scabiei
inactivated vaccines
scabies
serology
description 15 páginas, 1 tabla, 7 figuras.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/365685
https://api.elsevier.com/content/abstract/scopus_id/85189269323
url http://hdl.handle.net/10261/365685
https://api.elsevier.com/content/abstract/scopus_id/85189269323
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Veterinary research
http://dx.doi.org/doi.org/10.1186/s13567-024-01293-y
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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