Breast Milk Metabolomic Profile Is Associated With Maternal Overweight/Obesity Status or Adherence to Mediterranean Diet and Infant Weight Gain During the First Month of Lactation

ABSTRACT Breast milk provides a wide range of nutritional and bioactive components crucial for infant growth and development during lactation, ultimately influencing future health outcomes. Here, we used untargeted metabolomics to identify differences in the breast milk metabolome related to materna...

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Autores: Pomar, Catalina Amadora, Zouhar, Petr, DeLucas, María, Cajka, Tomas, Cobo, Pilar, Jiménez Cabanillas, María Victoria, Bibiloni, Pere, Kopecky, Jan, Palou, Andreu, Serra, Francisca, Sánchez, Juana, Picó, Catalina
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/26076
Acceso en línea:https://hdl.handle.net/20.500.13003/26076
Access Level:acceso abierto
Palabra clave:Breast Feeding
Growth
development
Diet, Mediterranean
Metabolome
Pediatric Obesity
Lactancia Materna
Crecimiento
desarrollo
Dieta Mediterránea
Metaboloma
Obesidad Infantil
breast milk
growth and development
Mediterranean diet
metabolome
pediatric obesity
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spelling Breast Milk Metabolomic Profile Is Associated With Maternal Overweight/Obesity Status or Adherence to Mediterranean Diet and Infant Weight Gain During the First Month of LactationPomar, Catalina AmadoraZouhar, PetrDeLucas, MaríaCajka, TomasCobo, PilarJiménez Cabanillas, María VictoriaBibiloni, PereKopecky, JanPalou, AndreuSerra, FranciscaSánchez, JuanaPicó, CatalinaBreast FeedingGrowthdevelopmentDiet, MediterraneanMetabolomePediatric ObesityLactancia MaternaCrecimientodesarrolloDieta MediterráneaMetabolomaObesidad Infantilbreast milkgrowth and developmentMediterranean dietmetabolomepediatric obesityABSTRACT Breast milk provides a wide range of nutritional and bioactive components crucial for infant growth and development during lactation, ultimately influencing future health outcomes. Here, we used untargeted metabolomics to identify differences in the breast milk metabolome related to maternal overweight/obesity and diet, assessing their influence on infant weight gain in the first month of lactation. Anthropometric data from 52 lactating mother–infant pairs were collected at birth and 1 month postpartum, along with breast milk samples. Information about food consumed the day before milk sampling (24‐h questionnaire) was collected, and a food frequency questionnaire was completed. Our findings reveal that mothers with overweight/obesity had greater lactose levels (p = 0.025) and lower levels of orotic acid (p = 0.002), 3‐indoxyl sulfate (p = 0.027), heneicosanoic acid (p = 0.040), and N1‐methylguanosine (p = 0.046) in milk than normal‐weight mothers. Notably, reduced orotic acid levels were associated with a greater infant weight gain during this period. Furthermore, mothers with a low adherence to the Mediterranean diet showed lower levels of citric acid (p = 0.041), N6‐succinyladenosine (p = 0.043), uric acid (p = 0.034), and eicosenoic acid (p = 0.035), and higher levels of acylcarnitine C6:0 (p = 0.041) than mothers with a medium/high adherence. Besides orotic acid, other milk metabolites were related to infant weight gain during this period, with maternal fruit and fish consumption (p = 0.015 and p = 0.017) emerging as the most influential dietary factor for an adequate early infant growth trajectory. None of the metabolites identified remained statistically significant after multiple‐comparisons adjustment. Present results, showing how maternal diet and obesity can affect breast milk metabolites and infant growth, offer insights to improve lactation‐feeding practices and support healthy infant development.Wiley20252025-04-2120252025-04-21research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/26076reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/260762026-06-22T12:44:07Z
dc.title.none.fl_str_mv Breast Milk Metabolomic Profile Is Associated With Maternal Overweight/Obesity Status or Adherence to Mediterranean Diet and Infant Weight Gain During the First Month of Lactation
title Breast Milk Metabolomic Profile Is Associated With Maternal Overweight/Obesity Status or Adherence to Mediterranean Diet and Infant Weight Gain During the First Month of Lactation
spellingShingle Breast Milk Metabolomic Profile Is Associated With Maternal Overweight/Obesity Status or Adherence to Mediterranean Diet and Infant Weight Gain During the First Month of Lactation
Pomar, Catalina Amadora
Breast Feeding
Growth
development
Diet, Mediterranean
Metabolome
Pediatric Obesity
Lactancia Materna
Crecimiento
desarrollo
Dieta Mediterránea
Metaboloma
Obesidad Infantil
breast milk
growth and development
Mediterranean diet
metabolome
pediatric obesity
title_short Breast Milk Metabolomic Profile Is Associated With Maternal Overweight/Obesity Status or Adherence to Mediterranean Diet and Infant Weight Gain During the First Month of Lactation
title_full Breast Milk Metabolomic Profile Is Associated With Maternal Overweight/Obesity Status or Adherence to Mediterranean Diet and Infant Weight Gain During the First Month of Lactation
title_fullStr Breast Milk Metabolomic Profile Is Associated With Maternal Overweight/Obesity Status or Adherence to Mediterranean Diet and Infant Weight Gain During the First Month of Lactation
title_full_unstemmed Breast Milk Metabolomic Profile Is Associated With Maternal Overweight/Obesity Status or Adherence to Mediterranean Diet and Infant Weight Gain During the First Month of Lactation
title_sort Breast Milk Metabolomic Profile Is Associated With Maternal Overweight/Obesity Status or Adherence to Mediterranean Diet and Infant Weight Gain During the First Month of Lactation
dc.creator.none.fl_str_mv Pomar, Catalina Amadora
Zouhar, Petr
DeLucas, María
Cajka, Tomas
Cobo, Pilar
Jiménez Cabanillas, María Victoria
Bibiloni, Pere
Kopecky, Jan
Palou, Andreu
Serra, Francisca
Sánchez, Juana
Picó, Catalina
author Pomar, Catalina Amadora
author_facet Pomar, Catalina Amadora
Zouhar, Petr
DeLucas, María
Cajka, Tomas
Cobo, Pilar
Jiménez Cabanillas, María Victoria
Bibiloni, Pere
Kopecky, Jan
Palou, Andreu
Serra, Francisca
Sánchez, Juana
Picó, Catalina
author_role author
author2 Zouhar, Petr
DeLucas, María
Cajka, Tomas
Cobo, Pilar
Jiménez Cabanillas, María Victoria
Bibiloni, Pere
Kopecky, Jan
Palou, Andreu
Serra, Francisca
Sánchez, Juana
Picó, Catalina
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Breast Feeding
Growth
development
Diet, Mediterranean
Metabolome
Pediatric Obesity
Lactancia Materna
Crecimiento
desarrollo
Dieta Mediterránea
Metaboloma
Obesidad Infantil
breast milk
growth and development
Mediterranean diet
metabolome
pediatric obesity
topic Breast Feeding
Growth
development
Diet, Mediterranean
Metabolome
Pediatric Obesity
Lactancia Materna
Crecimiento
desarrollo
Dieta Mediterránea
Metaboloma
Obesidad Infantil
breast milk
growth and development
Mediterranean diet
metabolome
pediatric obesity
description ABSTRACT Breast milk provides a wide range of nutritional and bioactive components crucial for infant growth and development during lactation, ultimately influencing future health outcomes. Here, we used untargeted metabolomics to identify differences in the breast milk metabolome related to maternal overweight/obesity and diet, assessing their influence on infant weight gain in the first month of lactation. Anthropometric data from 52 lactating mother–infant pairs were collected at birth and 1 month postpartum, along with breast milk samples. Information about food consumed the day before milk sampling (24‐h questionnaire) was collected, and a food frequency questionnaire was completed. Our findings reveal that mothers with overweight/obesity had greater lactose levels (p = 0.025) and lower levels of orotic acid (p = 0.002), 3‐indoxyl sulfate (p = 0.027), heneicosanoic acid (p = 0.040), and N1‐methylguanosine (p = 0.046) in milk than normal‐weight mothers. Notably, reduced orotic acid levels were associated with a greater infant weight gain during this period. Furthermore, mothers with a low adherence to the Mediterranean diet showed lower levels of citric acid (p = 0.041), N6‐succinyladenosine (p = 0.043), uric acid (p = 0.034), and eicosenoic acid (p = 0.035), and higher levels of acylcarnitine C6:0 (p = 0.041) than mothers with a medium/high adherence. Besides orotic acid, other milk metabolites were related to infant weight gain during this period, with maternal fruit and fish consumption (p = 0.015 and p = 0.017) emerging as the most influential dietary factor for an adequate early infant growth trajectory. None of the metabolites identified remained statistically significant after multiple‐comparisons adjustment. Present results, showing how maternal diet and obesity can affect breast milk metabolites and infant growth, offer insights to improve lactation‐feeding practices and support healthy infant development.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-04-21
2025
2025-04-21
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/26076
url https://hdl.handle.net/20.500.13003/26076
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.198674

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