Plasmodium vivax Malaria viewed through the lens of an eradicated European strain

The protozoan Plasmodium vivax is responsible for 42% of all cases of malaria outside Africa. The parasite is currently largely restricted to tropical and subtropical latitudes in Asia, Oceania and the Americas. Though, it was historically present in most of Europe before being finally eradicated du...

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Autores: van Dorp, Lucy, Gelabert, Pere, Rieux, Adrien, Manuel, Marc de, Dios, Toni de, Gopalakrishnan, Shyam, Carøe, Christian, Sandoval Velasco, Marcela, Fregel, Rosa, Olalde, Iñigo, Escosa, Raül, Aranda, Carles, Huijben, Silvie, Mueller, Ivo, Marquès i Bonet, Tomàs, 1975-, Balloux, François, Gilbert, M. Thomas P., Lalueza Fox, Carles, 1965-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/152059
Acceso en línea:https://hdl.handle.net/2445/152059
Access Level:acceso abierto
Palabra clave:Malària
Plasmodium vivax
Malaria
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spelling Plasmodium vivax Malaria viewed through the lens of an eradicated European strainvan Dorp, LucyGelabert, PereRieux, AdrienManuel, Marc deDios, Toni deGopalakrishnan, ShyamCarøe, ChristianSandoval Velasco, MarcelaFregel, RosaOlalde, IñigoEscosa, RaülAranda, CarlesHuijben, SilvieMueller, IvoMarquès i Bonet, Tomàs, 1975-Balloux, FrançoisGilbert, M. Thomas P.Lalueza Fox, Carles, 1965-MalàriaPlasmodium vivaxMalariaPlasmodium vivaxThe protozoan Plasmodium vivax is responsible for 42% of all cases of malaria outside Africa. The parasite is currently largely restricted to tropical and subtropical latitudes in Asia, Oceania and the Americas. Though, it was historically present in most of Europe before being finally eradicated during the second half of the 20th century. The lack of genomic information on the extinct European lineage has prevented a clear understanding of historical population structuring and past migrations of P. vivax. We used medical microscope slides prepared in 1944 from malaria-affected patients from the Ebro Delta in Spain, one of the last footholds of malaria in Europe, to generate a genome of a European P. vivax strain. Population genetics and phylogenetic analyses placed this strain basal to a cluster including samples from the Americas. This genome allowed us to calibrate a genomic mutation rate for P. vivax, and to estimate the mean age of the last common ancestor between European and American strains to the 15th century. This date points to an introduction of the parasite during the European colonisation of the Americas. In addition, we found that some known variants for resistance to anti-malarial drugs, including Chloroquine and Sulfadoxine, were already present in this European strain, predating their use. Our results shed light on the evolution of an important human pathogen and illustrate the value of antique medical collections as a resource for retrieving genomic information on pathogens from the past.Oxford University Press2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/152059Articles publicats en revistes (ISGlobal)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1093/molbev/msz264Molecular Biology and Evolution, 2019, vol. 37, num. 3, p. 773–785http://dx.doi.org/10.1093/molbev/msz264info:eu-repo/grantAgreement/EC/H2020/681396cc by-nc (c) van Dorp et al., 2019http://creativecommons.org/licenses/by-nc/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1520592026-05-27T06:46:51Z
dc.title.none.fl_str_mv Plasmodium vivax Malaria viewed through the lens of an eradicated European strain
title Plasmodium vivax Malaria viewed through the lens of an eradicated European strain
spellingShingle Plasmodium vivax Malaria viewed through the lens of an eradicated European strain
van Dorp, Lucy
Malària
Plasmodium vivax
Malaria
Plasmodium vivax
title_short Plasmodium vivax Malaria viewed through the lens of an eradicated European strain
title_full Plasmodium vivax Malaria viewed through the lens of an eradicated European strain
title_fullStr Plasmodium vivax Malaria viewed through the lens of an eradicated European strain
title_full_unstemmed Plasmodium vivax Malaria viewed through the lens of an eradicated European strain
title_sort Plasmodium vivax Malaria viewed through the lens of an eradicated European strain
dc.creator.none.fl_str_mv van Dorp, Lucy
Gelabert, Pere
Rieux, Adrien
Manuel, Marc de
Dios, Toni de
Gopalakrishnan, Shyam
Carøe, Christian
Sandoval Velasco, Marcela
Fregel, Rosa
Olalde, Iñigo
Escosa, Raül
Aranda, Carles
Huijben, Silvie
Mueller, Ivo
Marquès i Bonet, Tomàs, 1975-
Balloux, François
Gilbert, M. Thomas P.
Lalueza Fox, Carles, 1965-
author van Dorp, Lucy
author_facet van Dorp, Lucy
Gelabert, Pere
Rieux, Adrien
Manuel, Marc de
Dios, Toni de
Gopalakrishnan, Shyam
Carøe, Christian
Sandoval Velasco, Marcela
Fregel, Rosa
Olalde, Iñigo
Escosa, Raül
Aranda, Carles
Huijben, Silvie
Mueller, Ivo
Marquès i Bonet, Tomàs, 1975-
Balloux, François
Gilbert, M. Thomas P.
Lalueza Fox, Carles, 1965-
author_role author
author2 Gelabert, Pere
Rieux, Adrien
Manuel, Marc de
Dios, Toni de
Gopalakrishnan, Shyam
Carøe, Christian
Sandoval Velasco, Marcela
Fregel, Rosa
Olalde, Iñigo
Escosa, Raül
Aranda, Carles
Huijben, Silvie
Mueller, Ivo
Marquès i Bonet, Tomàs, 1975-
Balloux, François
Gilbert, M. Thomas P.
Lalueza Fox, Carles, 1965-
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malària
Plasmodium vivax
Malaria
Plasmodium vivax
topic Malària
Plasmodium vivax
Malaria
Plasmodium vivax
description The protozoan Plasmodium vivax is responsible for 42% of all cases of malaria outside Africa. The parasite is currently largely restricted to tropical and subtropical latitudes in Asia, Oceania and the Americas. Though, it was historically present in most of Europe before being finally eradicated during the second half of the 20th century. The lack of genomic information on the extinct European lineage has prevented a clear understanding of historical population structuring and past migrations of P. vivax. We used medical microscope slides prepared in 1944 from malaria-affected patients from the Ebro Delta in Spain, one of the last footholds of malaria in Europe, to generate a genome of a European P. vivax strain. Population genetics and phylogenetic analyses placed this strain basal to a cluster including samples from the Americas. This genome allowed us to calibrate a genomic mutation rate for P. vivax, and to estimate the mean age of the last common ancestor between European and American strains to the 15th century. This date points to an introduction of the parasite during the European colonisation of the Americas. In addition, we found that some known variants for resistance to anti-malarial drugs, including Chloroquine and Sulfadoxine, were already present in this European strain, predating their use. Our results shed light on the evolution of an important human pathogen and illustrate the value of antique medical collections as a resource for retrieving genomic information on pathogens from the past.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/152059
url https://hdl.handle.net/2445/152059
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1093/molbev/msz264
Molecular Biology and Evolution, 2019, vol. 37, num. 3, p. 773–785
http://dx.doi.org/10.1093/molbev/msz264
info:eu-repo/grantAgreement/EC/H2020/681396
dc.rights.none.fl_str_mv cc by-nc (c) van Dorp et al., 2019
http://creativecommons.org/licenses/by-nc/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc (c) van Dorp et al., 2019
http://creativecommons.org/licenses/by-nc/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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