The exposome in practice: Design of the EXPOsOMICS project

EXPOsOMICS is a European Union funded project that aims to develop a novel approach to the assessment of exposure to high priority environmental pollutants, by characterizing the external and the internal components of the exposome. It focuses on air and water contaminants during critical periods of...

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Detalles Bibliográficos
Autores: Vineis, Paolo, Chadeau-Hyam, Marc, Gmuender, Hans, Gulliver, John, Herceg, Zdenko, Kleinjans, Jos C. S., Kogevinas, Manolis, Kyrtopoulos, Soterios, Nieuwenhuijsen, Mark J., Phillips, David H., Probst-Hensch, Nicole M., Scalbert, Augustin, Vermeulen, Roel C. H., Wild, Christopher P., EXPOsOMICS Consortium
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/101652
Acceso en línea:https://hdl.handle.net/2445/101652
Access Level:acceso abierto
Palabra clave:Contaminació atmosfèrica
Contaminació de l'aigua
Atmospheric pollution
Water pollution
Descripción
Sumario:EXPOsOMICS is a European Union funded project that aims to develop a novel approach to the assessment of exposure to high priority environmental pollutants, by characterizing the external and the internal components of the exposome. It focuses on air and water contaminants during critical periods of life. To this end, the project centres on 1) exposure assessment at the personal and population levels within existing European short and long-term population studies, exploiting available tools and methods which have been developed for personal exposure monitoring (PEM); and 2) multiple "omic" technologies for the analysis of biological samples (internal markers of external exposures). The search for the relationships between external exposures and global profiles of molecular features in the same individuals constitutes a novel advancement towards the development of "next generation exposure assessment" for environmental chemicals and their mixtures. The linkage with disease risks opens the way to what are defined here as 'exposome-wide association studies' (EWAS).

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