Major Superficial White Matter Abnormalities in Huntington's Disease

Background: The late myelinating superficial white matter at the juncture of the cortical gray and white matter comprising the intracortical myelin and short-range association fibers has not received attention in Huntington's disease. It is an area of the brain that is late myelinating and is s...

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Autores: Phillips, Owen R., Joshi, Shantanu H., Squitieri, Ferdinando, Sánchez Castañeda, Cristina, Narr, Katherine, Shattuck, David W., Caltagirone, Carlo, Sabatini, Umberto, Di Paola, Margherita
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/140977
Acceso en línea:https://hdl.handle.net/2445/140977
Access Level:acceso abierto
Palabra clave:Corea de Huntington
Cervell
Imatges per ressonància magnètica
Huntington's chorea
Brain
Magnetic resonance imaging
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spelling Major Superficial White Matter Abnormalities in Huntington's DiseasePhillips, Owen R.Joshi, Shantanu H.Squitieri, FerdinandoSánchez Castañeda, CristinaNarr, KatherineShattuck, David W.Caltagirone, CarloSabatini, UmbertoDi Paola, MargheritaCorea de HuntingtonCervellImatges per ressonància magnèticaHuntington's choreaBrainMagnetic resonance imagingBackground: The late myelinating superficial white matter at the juncture of the cortical gray and white matter comprising the intracortical myelin and short-range association fibers has not received attention in Huntington's disease. It is an area of the brain that is late myelinating and is sensitive to both normal aging and neurodegenerative disease effects. Therefore, it may be sensitive to Huntington's disease processes. Methods: Structural MRI data from 25 Pre-symptomatic subjects, 24 Huntington's disease patients and 49 healthy controls was run through a cortical pattern-matching program. The surface corresponding to the white matter directly below the cortical gray matter was then extracted. Individual subject's Diffusion Tensor Imaging (DTI) data was aligned to their structural MRI data. Diffusivity values along the white matter surface were then sampled at each vertex point. DTI measures with high spatial resolution across the superficial white matter surface were then analyzed with the General Linear Model to test for the effects of disease. Results: There was an overall increase in the axial and radial diffusivity across much of the superficial white matter (p < 0.001) in Pre-symptomatic subjects compared to controls. In Huntington's disease patients increased diffusivity covered essentially the whole brain (p < 0.001). Changes are correlated with genotype (CAG repeat number) and disease burden (p < 0.001). Conclusions: This study showed broad abnormalities in superficial white matter even before symptoms are present in Huntington's disease. Since, the superficial white matter has a unique microstructure and function these abnormalities suggest it plays an important role in the disease.Frontiers Media2019201920162019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/140977Articles publicats en revistes (Psicologia Clínica i Psicobiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fnins.2016.00197Frontiers in Neuroscience, 2016, vol. 10, p. 197https://doi.org/10.3389/fnins.2016.00197cc-by (c) Phillips, Owen R. et al., 2016http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1409772026-05-29T05:05:01Z
dc.title.none.fl_str_mv Major Superficial White Matter Abnormalities in Huntington's Disease
title Major Superficial White Matter Abnormalities in Huntington's Disease
spellingShingle Major Superficial White Matter Abnormalities in Huntington's Disease
Phillips, Owen R.
Corea de Huntington
Cervell
Imatges per ressonància magnètica
Huntington's chorea
Brain
Magnetic resonance imaging
title_short Major Superficial White Matter Abnormalities in Huntington's Disease
title_full Major Superficial White Matter Abnormalities in Huntington's Disease
title_fullStr Major Superficial White Matter Abnormalities in Huntington's Disease
title_full_unstemmed Major Superficial White Matter Abnormalities in Huntington's Disease
title_sort Major Superficial White Matter Abnormalities in Huntington's Disease
dc.creator.none.fl_str_mv Phillips, Owen R.
Joshi, Shantanu H.
Squitieri, Ferdinando
Sánchez Castañeda, Cristina
Narr, Katherine
Shattuck, David W.
Caltagirone, Carlo
Sabatini, Umberto
Di Paola, Margherita
author Phillips, Owen R.
author_facet Phillips, Owen R.
Joshi, Shantanu H.
Squitieri, Ferdinando
Sánchez Castañeda, Cristina
Narr, Katherine
Shattuck, David W.
Caltagirone, Carlo
Sabatini, Umberto
Di Paola, Margherita
author_role author
author2 Joshi, Shantanu H.
Squitieri, Ferdinando
Sánchez Castañeda, Cristina
Narr, Katherine
Shattuck, David W.
Caltagirone, Carlo
Sabatini, Umberto
Di Paola, Margherita
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Corea de Huntington
Cervell
Imatges per ressonància magnètica
Huntington's chorea
Brain
Magnetic resonance imaging
topic Corea de Huntington
Cervell
Imatges per ressonància magnètica
Huntington's chorea
Brain
Magnetic resonance imaging
description Background: The late myelinating superficial white matter at the juncture of the cortical gray and white matter comprising the intracortical myelin and short-range association fibers has not received attention in Huntington's disease. It is an area of the brain that is late myelinating and is sensitive to both normal aging and neurodegenerative disease effects. Therefore, it may be sensitive to Huntington's disease processes. Methods: Structural MRI data from 25 Pre-symptomatic subjects, 24 Huntington's disease patients and 49 healthy controls was run through a cortical pattern-matching program. The surface corresponding to the white matter directly below the cortical gray matter was then extracted. Individual subject's Diffusion Tensor Imaging (DTI) data was aligned to their structural MRI data. Diffusivity values along the white matter surface were then sampled at each vertex point. DTI measures with high spatial resolution across the superficial white matter surface were then analyzed with the General Linear Model to test for the effects of disease. Results: There was an overall increase in the axial and radial diffusivity across much of the superficial white matter (p < 0.001) in Pre-symptomatic subjects compared to controls. In Huntington's disease patients increased diffusivity covered essentially the whole brain (p < 0.001). Changes are correlated with genotype (CAG repeat number) and disease burden (p < 0.001). Conclusions: This study showed broad abnormalities in superficial white matter even before symptoms are present in Huntington's disease. Since, the superficial white matter has a unique microstructure and function these abnormalities suggest it plays an important role in the disease.
publishDate 2016
dc.date.none.fl_str_mv 2016
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/140977
url https://hdl.handle.net/2445/140977
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fnins.2016.00197
Frontiers in Neuroscience, 2016, vol. 10, p. 197
https://doi.org/10.3389/fnins.2016.00197
dc.rights.none.fl_str_mv cc-by (c) Phillips, Owen R. et al., 2016
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Phillips, Owen R. et al., 2016
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Psicologia Clínica i Psicobiologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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