Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.

We found that specific manipulation of superficial but not deep pyramidal neurons of the CA1 resulted in the amelioration of depressive-like behaviors and the restoration of cognitive impairments induced by chronic stress. In summary, Egr1 might be a core molecule driving the activation/deactivation...

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Detalhes bibliográficos
Autores: Sancho Balsells, Anna, Borràs Pernas, Sara, Brito, Verónica, Alberch i Vié, Jordi, 1959-, Girault, Jean-Antoine, Giralt Torroella, Albert
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/207574
Acesso em linha:https://hdl.handle.net/2445/207574
Access Level:acceso abierto
Palavra-chave:Hipocamp (Cervell)
Neurones
Memòria
Esquizofrènia
Depressió psíquica
Estrès (Psicologia)
Hippocampus (Brain)
Neurons
Memory
Schizophrenia
Mental depression
Stress (Psychology)
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oai_identifier_str oai:diposit.ub.edu:2445/207574
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repository_id_str
spelling Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.Sancho Balsells, AnnaBorràs Pernas, SaraBrito, VerónicaAlberch i Vié, Jordi, 1959-Girault, Jean-AntoineGiralt Torroella, AlbertHipocamp (Cervell)NeuronesMemòriaEsquizofrèniaDepressió psíquicaEstrès (Psicologia)Hippocampus (Brain)NeuronsMemorySchizophreniaMental depressionStress (Psychology)We found that specific manipulation of superficial but not deep pyramidal neurons of the CA1 resulted in the amelioration of depressive-like behaviors and the restoration of cognitive impairments induced by chronic stress. In summary, Egr1 might be a core molecule driving the activation/deactivation of hippocampal neuronal subpopulations underlying stress-induced alterations involving emotional and cognitive sequels.MDPI2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/207574Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/ijms24043833International Journal of Molecular Sciences, 2023, vol. 24, num.4https://doi.org/10.3390/ijms24043833cc-by (c) Sancho-Balsells A. et al., 2023http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2075742026-05-27T06:46:51Z
dc.title.none.fl_str_mv Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.
title Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.
spellingShingle Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.
Sancho Balsells, Anna
Hipocamp (Cervell)
Neurones
Memòria
Esquizofrènia
Depressió psíquica
Estrès (Psicologia)
Hippocampus (Brain)
Neurons
Memory
Schizophrenia
Mental depression
Stress (Psychology)
title_short Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.
title_full Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.
title_fullStr Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.
title_full_unstemmed Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.
title_sort Cognitive and Emotional Symptoms Induced by Chronic Stress Are Regulated by EGR1 in a Subpopulation of Hippocampal Pyramidal Neurons.
dc.creator.none.fl_str_mv Sancho Balsells, Anna
Borràs Pernas, Sara
Brito, Verónica
Alberch i Vié, Jordi, 1959-
Girault, Jean-Antoine
Giralt Torroella, Albert
author Sancho Balsells, Anna
author_facet Sancho Balsells, Anna
Borràs Pernas, Sara
Brito, Verónica
Alberch i Vié, Jordi, 1959-
Girault, Jean-Antoine
Giralt Torroella, Albert
author_role author
author2 Borràs Pernas, Sara
Brito, Verónica
Alberch i Vié, Jordi, 1959-
Girault, Jean-Antoine
Giralt Torroella, Albert
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Hipocamp (Cervell)
Neurones
Memòria
Esquizofrènia
Depressió psíquica
Estrès (Psicologia)
Hippocampus (Brain)
Neurons
Memory
Schizophrenia
Mental depression
Stress (Psychology)
topic Hipocamp (Cervell)
Neurones
Memòria
Esquizofrènia
Depressió psíquica
Estrès (Psicologia)
Hippocampus (Brain)
Neurons
Memory
Schizophrenia
Mental depression
Stress (Psychology)
description We found that specific manipulation of superficial but not deep pyramidal neurons of the CA1 resulted in the amelioration of depressive-like behaviors and the restoration of cognitive impairments induced by chronic stress. In summary, Egr1 might be a core molecule driving the activation/deactivation of hippocampal neuronal subpopulations underlying stress-induced alterations involving emotional and cognitive sequels.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/207574
url https://hdl.handle.net/2445/207574
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms24043833
International Journal of Molecular Sciences, 2023, vol. 24, num.4
https://doi.org/10.3390/ijms24043833
dc.rights.none.fl_str_mv cc-by (c) Sancho-Balsells A. et al., 2023
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Sancho-Balsells A. et al., 2023
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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