Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, mainly due to late diagnosis at advanced tumor stages. In this study, we aimed to identify plasma protein biomarkers for early detection of PDAC. Totally, 135 PDAC patients (early PDAC, Stage I/II, n = 71; advanced PDAC, Stage III/IV, n =...
| Autores: | , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/46533 |
| Acceso en línea: | http://hdl.handle.net/10230/46533 http://dx.doi.org/10.1002/ijc.33464 |
| Access Level: | acceso abierto |
| Palabra clave: | AUC Biomarkers Early diagnosis Pancreatic ductal adenocarcinoma Proteomics |
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Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinomaYu, JingruPloner, AlexanderKordes, MaximilianLöhr, J. MatthiasNilsson, MagnusLópez De Maturana, EvangelinaEstudillo, LidiaRenz, HaraldCarrato, AlfredoMolero, XavierReal, Francisco X.Malats i Riera, NúriaYe, WeiminAUCBiomarkersEarly diagnosisPancreatic ductal adenocarcinomaProteomicsPancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, mainly due to late diagnosis at advanced tumor stages. In this study, we aimed to identify plasma protein biomarkers for early detection of PDAC. Totally, 135 PDAC patients (early PDAC, Stage I/II, n = 71; advanced PDAC, Stage III/IV, n = 64), 13 benign lesions/chronic pancreatitis patients and 72 healthy individuals, with corresponding plasma samples from a case-control study in Sweden were included. A proximity extension assay was used to detect 92 cancer-related proteins, and an enzyme-linked immunosorbent assay/electrochemiluminescence immunoassay was used to detect CA19-9. Predictive features were selected from these 93 candidate proteins and three covariates in the Swedish participants, and then validated in Spanish participants, including 37 early PDAC patients, 38 advanced PDAC patients, 19 chronic pancreatitis patients and 36 healthy controls. A panel of eight proteins discriminating early PDAC from healthy individuals was identified, and the cross-validated area under the curves (AUCs) were 0.85 (95% confidence interval, 95% CI, 0.78-0.91) and 0.81 (95% CI, 0.70-0.92) in the Swedish and Spanish participants, respectively. Another eight-protein panel was predictive for classifying advanced PDAC from healthy controls in two populations, with cross-validated AUCs of 0.89 (95% CI, 0.83-0.95) and 0.90 (95% CI, 0.83-0.98), respectively. In conclusion, eight protein biomarkers were identified and externally validated, potentially allowing early detection of PDAC patients if validated in additional prospective studies.Wiley202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/46533http://dx.doi.org/10.1002/ijc.33464reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésInt J Cancer. 2021; 148(8):2048-58© 2021 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/465332026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma |
| title |
Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma |
| spellingShingle |
Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma Yu, Jingru AUC Biomarkers Early diagnosis Pancreatic ductal adenocarcinoma Proteomics |
| title_short |
Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma |
| title_full |
Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma |
| title_fullStr |
Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma |
| title_full_unstemmed |
Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma |
| title_sort |
Plasma protein biomarkers for early detection of pancreatic ductal adenocarcinoma |
| dc.creator.none.fl_str_mv |
Yu, Jingru Ploner, Alexander Kordes, Maximilian Löhr, J. Matthias Nilsson, Magnus López De Maturana, Evangelina Estudillo, Lidia Renz, Harald Carrato, Alfredo Molero, Xavier Real, Francisco X. Malats i Riera, Núria Ye, Weimin |
| author |
Yu, Jingru |
| author_facet |
Yu, Jingru Ploner, Alexander Kordes, Maximilian Löhr, J. Matthias Nilsson, Magnus López De Maturana, Evangelina Estudillo, Lidia Renz, Harald Carrato, Alfredo Molero, Xavier Real, Francisco X. Malats i Riera, Núria Ye, Weimin |
| author_role |
author |
| author2 |
Ploner, Alexander Kordes, Maximilian Löhr, J. Matthias Nilsson, Magnus López De Maturana, Evangelina Estudillo, Lidia Renz, Harald Carrato, Alfredo Molero, Xavier Real, Francisco X. Malats i Riera, Núria Ye, Weimin |
| author2_role |
author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
AUC Biomarkers Early diagnosis Pancreatic ductal adenocarcinoma Proteomics |
| topic |
AUC Biomarkers Early diagnosis Pancreatic ductal adenocarcinoma Proteomics |
| description |
Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, mainly due to late diagnosis at advanced tumor stages. In this study, we aimed to identify plasma protein biomarkers for early detection of PDAC. Totally, 135 PDAC patients (early PDAC, Stage I/II, n = 71; advanced PDAC, Stage III/IV, n = 64), 13 benign lesions/chronic pancreatitis patients and 72 healthy individuals, with corresponding plasma samples from a case-control study in Sweden were included. A proximity extension assay was used to detect 92 cancer-related proteins, and an enzyme-linked immunosorbent assay/electrochemiluminescence immunoassay was used to detect CA19-9. Predictive features were selected from these 93 candidate proteins and three covariates in the Swedish participants, and then validated in Spanish participants, including 37 early PDAC patients, 38 advanced PDAC patients, 19 chronic pancreatitis patients and 36 healthy controls. A panel of eight proteins discriminating early PDAC from healthy individuals was identified, and the cross-validated area under the curves (AUCs) were 0.85 (95% confidence interval, 95% CI, 0.78-0.91) and 0.81 (95% CI, 0.70-0.92) in the Swedish and Spanish participants, respectively. Another eight-protein panel was predictive for classifying advanced PDAC from healthy controls in two populations, with cross-validated AUCs of 0.89 (95% CI, 0.83-0.95) and 0.90 (95% CI, 0.83-0.98), respectively. In conclusion, eight protein biomarkers were identified and externally validated, potentially allowing early detection of PDAC patients if validated in additional prospective studies. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021 2021 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/46533 http://dx.doi.org/10.1002/ijc.33464 |
| url |
http://hdl.handle.net/10230/46533 http://dx.doi.org/10.1002/ijc.33464 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Int J Cancer. 2021; 148(8):2048-58 |
| dc.rights.none.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf application/pdf |
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Wiley |
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Wiley |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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