Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents
Background: Prenatal exposure to persistent organic pollutants (POPs) has been linked to cardiometabolic (CM) risk factors in childhood, but there are no studies evaluating the persistence of these associations into adolescence, a period of relevant changes in endocrine-dependent organ systems and r...
| Autores: | , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Recursos: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/47218 |
| Acesso em linha: | http://hdl.handle.net/10230/47218 http://dx.doi.org/10.1016/j.envint.2021.106469 |
| Access Level: | acceso abierto |
| Palavra-chave: | Cardiometabolic syndrome Dichlorodiphenyltrichloroethane (p,p’-DDT) Endocrine disruptors Hexachlorobenzene (HCB) Persistent organic pollutants (POPs) Polychlorinated biphenyls (PCBs) |
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Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents |
| title |
Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents |
| spellingShingle |
Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents Güil Oumrait, Núria Cardiometabolic syndrome Dichlorodiphenyltrichloroethane (p,p’-DDT) Endocrine disruptors Hexachlorobenzene (HCB) Persistent organic pollutants (POPs) Polychlorinated biphenyls (PCBs) |
| title_short |
Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents |
| title_full |
Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents |
| title_fullStr |
Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents |
| title_full_unstemmed |
Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents |
| title_sort |
Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents |
| dc.creator.none.fl_str_mv |
Güil Oumrait, Núria Valvi, Damaskini, 1983- García Esteban, Raquel Guxens Junyent, Mònica Sunyer Deu, Jordi Torrent Quetglas, Maties Casas Sanahuja, Maribel Vrijheid, Martine |
| author |
Güil Oumrait, Núria |
| author_facet |
Güil Oumrait, Núria Valvi, Damaskini, 1983- García Esteban, Raquel Guxens Junyent, Mònica Sunyer Deu, Jordi Torrent Quetglas, Maties Casas Sanahuja, Maribel Vrijheid, Martine |
| author_role |
author |
| author2 |
Valvi, Damaskini, 1983- García Esteban, Raquel Guxens Junyent, Mònica Sunyer Deu, Jordi Torrent Quetglas, Maties Casas Sanahuja, Maribel Vrijheid, Martine |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
Cardiometabolic syndrome Dichlorodiphenyltrichloroethane (p,p’-DDT) Endocrine disruptors Hexachlorobenzene (HCB) Persistent organic pollutants (POPs) Polychlorinated biphenyls (PCBs) |
| topic |
Cardiometabolic syndrome Dichlorodiphenyltrichloroethane (p,p’-DDT) Endocrine disruptors Hexachlorobenzene (HCB) Persistent organic pollutants (POPs) Polychlorinated biphenyls (PCBs) |
| description |
Background: Prenatal exposure to persistent organic pollutants (POPs) has been linked to cardiometabolic (CM) risk factors in childhood, but there are no studies evaluating the persistence of these associations into adolescence, a period of relevant changes in endocrine-dependent organ systems and rapid increases in lean and fat mass. We examined the associations of prenatal POP exposures with body mass index (BMI) from age 4 to 18 years, and with other CM risk markers in adolescence. Methods: We analysed 379 children from the Spanish INMA-Menorca birth cohort study with measured cord blood POP concentrations. We calculated BMI z-scores at ages 4, 6, 11, 14 and 18 years using the WHO growth reference. Body fat % was measured at 11 and 18 years and waist-to-height ratio (WHtR) and blood pressure (BP) at 11, 14 and 18 years. We measured CM biomarkers in fasting blood collected at age 14 years and calculated a CM-risk score as the sum of the sex-, and age-specific z-scores for waist circumference, mean arterial BP, homeostatic model assessment of insulin resistance, fasting blood triglycerides, and high-density lipoprotein cholesterol (HDL-C) (n = 217). Generalised estimating equations and multivariate linear regression models assessed the associations with repeated and single time-point measures, respectively. Results: Hexachlorobenzene (HCB) exposure in the third tertile, compared to the first tertile, was associated with higher BMI (β = 0.24; 95% CI: 0.01, 0.47) and WHtR z-score (β = 0.27; 95% CI: 0.04, 0.51). A continuous increase in HCB was associated with an elevated body fat % (β per 10-fold increase = 4.21; 95% CI: 0.51, 7.92), systolic BP (β = 0.32; 95% CI: 0.02, 0.64) and diastolic BP z-score (β = 0.32; 95% CI: 0.02, 0.62) across all ages, and with higher CM-risk score (β = 1.59; 95% CI: 0.02, 3.18) and lipid biomarkers (total cholesterol, triglycerides and low-density lipoprotein cholesterol (LDL-C)) at 14 years. Dichlorodiphenyltrichloroethane (p,p'-DDT) exposure was non-monotonically associated with BMI and systolic BP. p,p'-DDE and Σ-polychlorinated biphenyls (PCBs) (sum of congeners 118, 138, 153, 180) were not associated with adiposity or BP. p,p'-DDT exposure was associated with an increased CM-risk score, and ΣPCBs concentrations with LDL-C in all adolescents and with total cholesterol only in girls (p-sex interaction = 0.05). Conclusion: This first longitudinal study from 4 to 18 years suggests that the previously reported POP associations with child BMI persist later in adolescence and that prenatal POP exposures are associated with major risk factors for adult CM syndrome. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2021 2021 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/10230/47218 http://dx.doi.org/10.1016/j.envint.2021.106469 |
| url |
http://hdl.handle.net/10230/47218 http://dx.doi.org/10.1016/j.envint.2021.106469 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
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Environ Int. 2021;151:106469 info:eu-repo/grantAgreement/EC/H2020/825712 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf application/pdf |
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Elsevier |
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Elsevier |
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reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra |
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Universitat Pompeu Fabra |
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Repositorio Digital de la UPF |
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Repositorio Digital de la UPF |
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1869407560546648064 |
| spelling |
Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescentsGüil Oumrait, NúriaValvi, Damaskini, 1983-García Esteban, RaquelGuxens Junyent, MònicaSunyer Deu, JordiTorrent Quetglas, MatiesCasas Sanahuja, MaribelVrijheid, MartineCardiometabolic syndromeDichlorodiphenyltrichloroethane (p,p’-DDT)Endocrine disruptorsHexachlorobenzene (HCB)Persistent organic pollutants (POPs)Polychlorinated biphenyls (PCBs)Background: Prenatal exposure to persistent organic pollutants (POPs) has been linked to cardiometabolic (CM) risk factors in childhood, but there are no studies evaluating the persistence of these associations into adolescence, a period of relevant changes in endocrine-dependent organ systems and rapid increases in lean and fat mass. We examined the associations of prenatal POP exposures with body mass index (BMI) from age 4 to 18 years, and with other CM risk markers in adolescence. Methods: We analysed 379 children from the Spanish INMA-Menorca birth cohort study with measured cord blood POP concentrations. We calculated BMI z-scores at ages 4, 6, 11, 14 and 18 years using the WHO growth reference. Body fat % was measured at 11 and 18 years and waist-to-height ratio (WHtR) and blood pressure (BP) at 11, 14 and 18 years. We measured CM biomarkers in fasting blood collected at age 14 years and calculated a CM-risk score as the sum of the sex-, and age-specific z-scores for waist circumference, mean arterial BP, homeostatic model assessment of insulin resistance, fasting blood triglycerides, and high-density lipoprotein cholesterol (HDL-C) (n = 217). Generalised estimating equations and multivariate linear regression models assessed the associations with repeated and single time-point measures, respectively. Results: Hexachlorobenzene (HCB) exposure in the third tertile, compared to the first tertile, was associated with higher BMI (β = 0.24; 95% CI: 0.01, 0.47) and WHtR z-score (β = 0.27; 95% CI: 0.04, 0.51). A continuous increase in HCB was associated with an elevated body fat % (β per 10-fold increase = 4.21; 95% CI: 0.51, 7.92), systolic BP (β = 0.32; 95% CI: 0.02, 0.64) and diastolic BP z-score (β = 0.32; 95% CI: 0.02, 0.62) across all ages, and with higher CM-risk score (β = 1.59; 95% CI: 0.02, 3.18) and lipid biomarkers (total cholesterol, triglycerides and low-density lipoprotein cholesterol (LDL-C)) at 14 years. Dichlorodiphenyltrichloroethane (p,p'-DDT) exposure was non-monotonically associated with BMI and systolic BP. p,p'-DDE and Σ-polychlorinated biphenyls (PCBs) (sum of congeners 118, 138, 153, 180) were not associated with adiposity or BP. p,p'-DDT exposure was associated with an increased CM-risk score, and ΣPCBs concentrations with LDL-C in all adolescents and with total cholesterol only in girls (p-sex interaction = 0.05). Conclusion: This first longitudinal study from 4 to 18 years suggests that the previously reported POP associations with child BMI persist later in adolescence and that prenatal POP exposures are associated with major risk factors for adult CM syndrome.This study received funding from the European Community’s Horizon 2020 programme under grant agreement no 825712, the Oberon project. The Menorca cohort was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176; CB06/02/0041; 97/0588; 00/0021-2; PI061756; PS0901958; PI14/00677 incl. FEDER funds), CIBERESP, Beca de la IV convocatoria de Ayudas a la Investigación en Enfermedades Neurodegenerativas de La Caixa, and EC Contract No. QLK4-CT-2000-00263.Elsevier202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/47218http://dx.doi.org/10.1016/j.envint.2021.106469reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésEnviron Int. 2021;151:106469info:eu-repo/grantAgreement/EC/H2020/825712© 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/472182026-06-12T07:21:37Z |
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15.198674 |