Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity-a pilot study
Background: Periprostatic adipose tissue (PPAT) has been recognized to associate with prostate cancer (PCa) aggressiveness and progression. Here, we sought to investigate whether excess adiposity modulates the methylome of PPAT in PCa patients. DNA methylation profiling was performed in PPAT from ob...
| Autores: | , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/64841 |
| Acceso en línea: | https://hdl.handle.net/10171/64841 |
| Access Level: | acceso abierto |
| Palabra clave: | DNA methylation Periprostatic adipose tissue Obesity Prostate cancer Microenvironment |
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Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity-a pilot studyCheng, Y. (Yan)|||/items/17f91592-112b-4f6d-8251-fb09d1dca92eMonteiro, C. (Cátia)|||/items/66830b3f-8ce5-4adb-b982-5528a56b6d85Matos, A. (Andreia)|||/items/e73d2e40-d96d-4ad5-8374-cfc9f5bae71eYou, J. (Jiaying)|||/items/28d9cd0c-7420-4d18-8ac9-3e634c681bc7Fraga, A. (Avelino)|||/items/f0c31cc8-d4b8-49ff-b4fd-c0b540c475e3Pereira, C. (Carina)|||/items/f0b8f462-5a63-4fba-af6f-fcaa489d6d2dCatalán-Goñi, V. (Victoria)|||/items/9a5a055c-323a-4b41-800f-65abf7f22c79Rodriguez, A. (Amaia)|||/items/50976a5f-9842-47f1-8a9c-508e59996427Gomez-Ambrosi, J. (Javier)|||/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8eFrühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663bRibeiro, R. (Ricardo)|||/items/95aafc4b-5ad7-423d-bba2-fc4cb0710829Hu, P. (Pingzhao)|||/items/03ba1c6a-a254-4487-b59c-eb41b17b1dbaDNA methylationPeriprostatic adipose tissueObesityProstate cancerMicroenvironmentBackground: Periprostatic adipose tissue (PPAT) has been recognized to associate with prostate cancer (PCa) aggressiveness and progression. Here, we sought to investigate whether excess adiposity modulates the methylome of PPAT in PCa patients. DNA methylation profiling was performed in PPAT from obese/overweight (OB/OW, BMI > 25 kg m−2 ) and normal weight (NW, BMI < 25 kg m−2 ) PCa patients. Significant differences in methylated CpGs between OB/OW and NW groups were inferred by statistical modeling. Results: Five thousand five hundred twenty-six differentially methylated CpGs were identified between OB/OW and NW PCa patients with 90.2% hypermethylated. Four hundred eighty-three of these CpGs were found to be located at both promoters and CpG islands, whereas the representing 412 genes were found to be involved in pluripotency of stem cells, fatty acid metabolism, and many other biological processes; 14 of these genes, particularly FADS1, MOGAT1, and PCYT2, with promoter hypermethylation presented with significantly decreased gene expression in matched samples. Additionally, 38 genes were correlated with antigen processing and presentation of endogenous antigen via MHC class I, which might result in fatty acid accumulation in PPAT and tumor immune evasion. Conclusions: Results showed that the whole epigenome methylation profiles of PPAT were significantly different in OB/OW compared to normal weight PCa patients. The epigenetic variation associated with excess adiposity likely resulted in altered lipid metabolism and immune dysregulation, contributing towards unfavorable PCa microenvironment, thus warranting further validation studies in larger samples.BioMed CentralDadun. Depósito Académico Digital Universidad de Navarra20222022-12-1420182018-01-0120182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/64841reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/648412026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity-a pilot study |
| title |
Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity-a pilot study |
| spellingShingle |
Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity-a pilot study Cheng, Y. (Yan)|||/items/17f91592-112b-4f6d-8251-fb09d1dca92e DNA methylation Periprostatic adipose tissue Obesity Prostate cancer Microenvironment |
| title_short |
Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity-a pilot study |
| title_full |
Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity-a pilot study |
| title_fullStr |
Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity-a pilot study |
| title_full_unstemmed |
Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity-a pilot study |
| title_sort |
Epigenome-wide DNA methylation profiling of periprostatic adipose tissue in prostate cancer patients with excess adiposity-a pilot study |
| dc.creator.none.fl_str_mv |
Cheng, Y. (Yan)|||/items/17f91592-112b-4f6d-8251-fb09d1dca92e Monteiro, C. (Cátia)|||/items/66830b3f-8ce5-4adb-b982-5528a56b6d85 Matos, A. (Andreia)|||/items/e73d2e40-d96d-4ad5-8374-cfc9f5bae71e You, J. (Jiaying)|||/items/28d9cd0c-7420-4d18-8ac9-3e634c681bc7 Fraga, A. (Avelino)|||/items/f0c31cc8-d4b8-49ff-b4fd-c0b540c475e3 Pereira, C. (Carina)|||/items/f0b8f462-5a63-4fba-af6f-fcaa489d6d2d Catalán-Goñi, V. (Victoria)|||/items/9a5a055c-323a-4b41-800f-65abf7f22c79 Rodriguez, A. (Amaia)|||/items/50976a5f-9842-47f1-8a9c-508e59996427 Gomez-Ambrosi, J. (Javier)|||/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8e Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b Ribeiro, R. (Ricardo)|||/items/95aafc4b-5ad7-423d-bba2-fc4cb0710829 Hu, P. (Pingzhao)|||/items/03ba1c6a-a254-4487-b59c-eb41b17b1dba |
| author |
Cheng, Y. (Yan)|||/items/17f91592-112b-4f6d-8251-fb09d1dca92e |
| author_facet |
Cheng, Y. (Yan)|||/items/17f91592-112b-4f6d-8251-fb09d1dca92e Monteiro, C. (Cátia)|||/items/66830b3f-8ce5-4adb-b982-5528a56b6d85 Matos, A. (Andreia)|||/items/e73d2e40-d96d-4ad5-8374-cfc9f5bae71e You, J. (Jiaying)|||/items/28d9cd0c-7420-4d18-8ac9-3e634c681bc7 Fraga, A. (Avelino)|||/items/f0c31cc8-d4b8-49ff-b4fd-c0b540c475e3 Pereira, C. (Carina)|||/items/f0b8f462-5a63-4fba-af6f-fcaa489d6d2d Catalán-Goñi, V. (Victoria)|||/items/9a5a055c-323a-4b41-800f-65abf7f22c79 Rodriguez, A. (Amaia)|||/items/50976a5f-9842-47f1-8a9c-508e59996427 Gomez-Ambrosi, J. (Javier)|||/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8e Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b Ribeiro, R. (Ricardo)|||/items/95aafc4b-5ad7-423d-bba2-fc4cb0710829 Hu, P. (Pingzhao)|||/items/03ba1c6a-a254-4487-b59c-eb41b17b1dba |
| author_role |
author |
| author2 |
Monteiro, C. (Cátia)|||/items/66830b3f-8ce5-4adb-b982-5528a56b6d85 Matos, A. (Andreia)|||/items/e73d2e40-d96d-4ad5-8374-cfc9f5bae71e You, J. (Jiaying)|||/items/28d9cd0c-7420-4d18-8ac9-3e634c681bc7 Fraga, A. (Avelino)|||/items/f0c31cc8-d4b8-49ff-b4fd-c0b540c475e3 Pereira, C. (Carina)|||/items/f0b8f462-5a63-4fba-af6f-fcaa489d6d2d Catalán-Goñi, V. (Victoria)|||/items/9a5a055c-323a-4b41-800f-65abf7f22c79 Rodriguez, A. (Amaia)|||/items/50976a5f-9842-47f1-8a9c-508e59996427 Gomez-Ambrosi, J. (Javier)|||/items/21d09997-940a-45f7-9b4b-0a9f64b2ed8e Frühbeck, G. (Gema)|||/items/7f0b1f72-bc91-4ab0-a3fd-21e9a3fb663b Ribeiro, R. (Ricardo)|||/items/95aafc4b-5ad7-423d-bba2-fc4cb0710829 Hu, P. (Pingzhao)|||/items/03ba1c6a-a254-4487-b59c-eb41b17b1dba |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
DNA methylation Periprostatic adipose tissue Obesity Prostate cancer Microenvironment |
| topic |
DNA methylation Periprostatic adipose tissue Obesity Prostate cancer Microenvironment |
| description |
Background: Periprostatic adipose tissue (PPAT) has been recognized to associate with prostate cancer (PCa) aggressiveness and progression. Here, we sought to investigate whether excess adiposity modulates the methylome of PPAT in PCa patients. DNA methylation profiling was performed in PPAT from obese/overweight (OB/OW, BMI > 25 kg m−2 ) and normal weight (NW, BMI < 25 kg m−2 ) PCa patients. Significant differences in methylated CpGs between OB/OW and NW groups were inferred by statistical modeling. Results: Five thousand five hundred twenty-six differentially methylated CpGs were identified between OB/OW and NW PCa patients with 90.2% hypermethylated. Four hundred eighty-three of these CpGs were found to be located at both promoters and CpG islands, whereas the representing 412 genes were found to be involved in pluripotency of stem cells, fatty acid metabolism, and many other biological processes; 14 of these genes, particularly FADS1, MOGAT1, and PCYT2, with promoter hypermethylation presented with significantly decreased gene expression in matched samples. Additionally, 38 genes were correlated with antigen processing and presentation of endogenous antigen via MHC class I, which might result in fatty acid accumulation in PPAT and tumor immune evasion. Conclusions: Results showed that the whole epigenome methylation profiles of PPAT were significantly different in OB/OW compared to normal weight PCa patients. The epigenetic variation associated with excess adiposity likely resulted in altered lipid metabolism and immune dysregulation, contributing towards unfavorable PCa microenvironment, thus warranting further validation studies in larger samples. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018 2018-01-01 2018 2018-01-01 2022 2022-12-14 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/64841 |
| url |
https://hdl.handle.net/10171/64841 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
BioMed Central |
| publisher.none.fl_str_mv |
BioMed Central |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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1869407558506119168 |
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15.301603 |