Platelet-rich plasma with versus without hyaluronic acid for hip osteoarthritis : a systematic review and meta-analysis
Background: The use of intra-articular orthobiologics in hip osteoarthritis (HOA) has been presented as a therapeutic option and to postpone arthroplasty. There is little scientific evidence on the clinical application of platelet-rich plasma (PRP) associated with hyaluronic acid as dual therapy. Th...
| Autores: | , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad de Málaga |
| Repositorio: | DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria |
| Idioma: | inglés |
| OAI Identifier: | oai:ddfv.ufv.es:10641/6348 |
| Acceso en línea: | https://hdl.handle.net/10641/6348 |
| Access Level: | acceso abierto |
| Palabra clave: | PRP hip hyaluronic acid osteoarthritis platelet viscosupplementation Biotechnology Bioengineering Histology Biomedical Engineering Journal Article Systematic Review Yes yes |
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Platelet-rich plasma with versus without hyaluronic acid for hip osteoarthritis : a systematic review and meta-analysisSantiago, Michael SilveiraDoria, Felipe MeirelesMorais Sirqueira Neto, JoséFontes, Fabio FrançaPorto, Erick SobralAidar, Felipe J.Silva, Marcus Vinicius Vieira de Matos PereiraCavalcante, Deivyd Vieira SilvaAkbarpoor, FatemehZamora, Fernanda ValerianoSouza, Davi Teixeira deMadruga, Reuthemann Esequias Teixeira Tenorio AlbuquerqueDíaz-de-Durana, Alfonso LópezMerino Fernández, MaríaMerino-Fernandez, MaríaCipolotti, RosanaPRPhiphyaluronic acidosteoarthritisplateletviscosupplementationBiotechnologyBioengineeringHistologyBiomedical EngineeringJournal ArticleSystematic ReviewYesyesBackground: The use of intra-articular orthobiologics in hip osteoarthritis (HOA) has been presented as a therapeutic option and to postpone arthroplasty. There is little scientific evidence on the clinical application of platelet-rich plasma (PRP) associated with hyaluronic acid as dual therapy. Thus, the aim of our systematic review is to compare the clinical improvement with the use of PRP with versus without hyaluronic acid (HA) in hip osteoarthritis. Methods: We systematically searched Cochrane, PubMed, and Embase databases for studies evaluating patients with HOA who received PRP with vs. without HA. Pain and functional score were collected and pooled at 3-, 6-, and 12-months follow-up. Mean differences (MD) and 95% intervals were calculated, and heterogeneity was assessed using I2 statistics. All statistical analysis was performed using R with the meta package. Results: We included 2 randomized controlled trials (RCTs) and 1 cohort study, comprising 190 patients, of whom 88 received the PRP plus HA. Relative to PRP alone, dual therapy led to significantly higher pain scores at 3 months (SMD 0.35; 95% CI 0.06 to 0.64; p < 0.01; I2 = 0%) and at 12 months (MD 11.92 points; 95% CI 3.87 to 19.97; p < 0.01; I2 = 0%), translating into worsening of pain including HA. There was no difference between groups at any follow-up regarding functional score or pain at 6 months. Conclusion: Joint infiltration in HOA with PRP combined to HA showed higher perception of pain scores. Our findings suggest that the addition of HA in PRP treatment does not bring significant improvement and worsens patients’ quality of life. However, more randomized trials with larger populations may increase robustness.Facultad de Ciencias de la Salud20252025-01-0120252025-01-01review articlehttp://purl.org/coar/resource_type/c_dcae04bcinfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10641/6348reponame:DDFV. Repositorio Institucional de la Universidad Francisco de Vitoriainstname:Universidad de MálagaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddfv.ufv.es:10641/63482026-06-11T12:44:57Z |
| dc.title.none.fl_str_mv |
Platelet-rich plasma with versus without hyaluronic acid for hip osteoarthritis : a systematic review and meta-analysis |
| title |
Platelet-rich plasma with versus without hyaluronic acid for hip osteoarthritis : a systematic review and meta-analysis |
| spellingShingle |
Platelet-rich plasma with versus without hyaluronic acid for hip osteoarthritis : a systematic review and meta-analysis Santiago, Michael Silveira PRP hip hyaluronic acid osteoarthritis platelet viscosupplementation Biotechnology Bioengineering Histology Biomedical Engineering Journal Article Systematic Review Yes yes |
| title_short |
Platelet-rich plasma with versus without hyaluronic acid for hip osteoarthritis : a systematic review and meta-analysis |
| title_full |
Platelet-rich plasma with versus without hyaluronic acid for hip osteoarthritis : a systematic review and meta-analysis |
| title_fullStr |
Platelet-rich plasma with versus without hyaluronic acid for hip osteoarthritis : a systematic review and meta-analysis |
| title_full_unstemmed |
Platelet-rich plasma with versus without hyaluronic acid for hip osteoarthritis : a systematic review and meta-analysis |
| title_sort |
Platelet-rich plasma with versus without hyaluronic acid for hip osteoarthritis : a systematic review and meta-analysis |
| dc.creator.none.fl_str_mv |
Santiago, Michael Silveira Doria, Felipe Meireles Morais Sirqueira Neto, José Fontes, Fabio França Porto, Erick Sobral Aidar, Felipe J. Silva, Marcus Vinicius Vieira de Matos Pereira Cavalcante, Deivyd Vieira Silva Akbarpoor, Fatemeh Zamora, Fernanda Valeriano Souza, Davi Teixeira de Madruga, Reuthemann Esequias Teixeira Tenorio Albuquerque Díaz-de-Durana, Alfonso López Merino Fernández, María Merino-Fernandez, María Cipolotti, Rosana |
| author |
Santiago, Michael Silveira |
| author_facet |
Santiago, Michael Silveira Doria, Felipe Meireles Morais Sirqueira Neto, José Fontes, Fabio França Porto, Erick Sobral Aidar, Felipe J. Silva, Marcus Vinicius Vieira de Matos Pereira Cavalcante, Deivyd Vieira Silva Akbarpoor, Fatemeh Zamora, Fernanda Valeriano Souza, Davi Teixeira de Madruga, Reuthemann Esequias Teixeira Tenorio Albuquerque Díaz-de-Durana, Alfonso López Merino Fernández, María Merino-Fernandez, María Cipolotti, Rosana |
| author_role |
author |
| author2 |
Doria, Felipe Meireles Morais Sirqueira Neto, José Fontes, Fabio França Porto, Erick Sobral Aidar, Felipe J. Silva, Marcus Vinicius Vieira de Matos Pereira Cavalcante, Deivyd Vieira Silva Akbarpoor, Fatemeh Zamora, Fernanda Valeriano Souza, Davi Teixeira de Madruga, Reuthemann Esequias Teixeira Tenorio Albuquerque Díaz-de-Durana, Alfonso López Merino Fernández, María Merino-Fernandez, María Cipolotti, Rosana |
| author2_role |
author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Facultad de Ciencias de la Salud |
| dc.subject.none.fl_str_mv |
PRP hip hyaluronic acid osteoarthritis platelet viscosupplementation Biotechnology Bioengineering Histology Biomedical Engineering Journal Article Systematic Review Yes yes |
| topic |
PRP hip hyaluronic acid osteoarthritis platelet viscosupplementation Biotechnology Bioengineering Histology Biomedical Engineering Journal Article Systematic Review Yes yes |
| description |
Background: The use of intra-articular orthobiologics in hip osteoarthritis (HOA) has been presented as a therapeutic option and to postpone arthroplasty. There is little scientific evidence on the clinical application of platelet-rich plasma (PRP) associated with hyaluronic acid as dual therapy. Thus, the aim of our systematic review is to compare the clinical improvement with the use of PRP with versus without hyaluronic acid (HA) in hip osteoarthritis. Methods: We systematically searched Cochrane, PubMed, and Embase databases for studies evaluating patients with HOA who received PRP with vs. without HA. Pain and functional score were collected and pooled at 3-, 6-, and 12-months follow-up. Mean differences (MD) and 95% intervals were calculated, and heterogeneity was assessed using I2 statistics. All statistical analysis was performed using R with the meta package. Results: We included 2 randomized controlled trials (RCTs) and 1 cohort study, comprising 190 patients, of whom 88 received the PRP plus HA. Relative to PRP alone, dual therapy led to significantly higher pain scores at 3 months (SMD 0.35; 95% CI 0.06 to 0.64; p < 0.01; I2 = 0%) and at 12 months (MD 11.92 points; 95% CI 3.87 to 19.97; p < 0.01; I2 = 0%), translating into worsening of pain including HA. There was no difference between groups at any follow-up regarding functional score or pain at 6 months. Conclusion: Joint infiltration in HOA with PRP combined to HA showed higher perception of pain scores. Our findings suggest that the addition of HA in PRP treatment does not bring significant improvement and worsens patients’ quality of life. However, more randomized trials with larger populations may increase robustness. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 2025-01-01 2025 2025-01-01 |
| dc.type.none.fl_str_mv |
review article http://purl.org/coar/resource_type/c_dcae04bc |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10641/6348 |
| url |
https://hdl.handle.net/10641/6348 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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reponame:DDFV. Repositorio Institucional de la Universidad Francisco de Vitoria instname:Universidad de Málaga |
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Universidad de Málaga |
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