Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network

Demetri, G. D.; Antonescu, Cristina R.; Bjerkehagen, B.; Bovee, J. V. M. G.; Boye, K.; Chacón, Matias; Dei Tos, Angelo Paolo; Desai, Jayesh; Fletcher, Jonathan A.; Gelderblom, Hans; George, Suzanne; Gronchi, Alesandro; Haas, R. L.; Hindi, Nadia; Hohenberger, Peter; Joensuu, Heikki; Jones, Robin L.; Judson, I.; Kang, Y.-K.; Kawai, Akira; Lazar, A. J.; Cesne, Axel Le; Maestro, Roberta; Maki, Robert; Martín, J.; Patel, S.; Penault-Llorca, F.; Premanand Raut, C.; Rutkowski, Piotr; Safwat, A. A.; Sbaraglia, Marta; Schaefer, I.-M.; Shen, L.; Serrano, C.; Schöffski, P.; Stacchiotti, Silvia; Sundby Hall, K.; Tap, William D.; Thomas, David M.; Trent, J.; Valverde, Claudia M.; Graaf, W.T.A. van der; Mehren, M. von; Wagner, Andrew J.; Wardelmann, Eva; Naito, Y.; Zalcberg, J.; Blay, Jean-Yves

Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network

Detalles Bibliográficos
Autores:	Demetri, G. D., Antonescu, Cristina R., Bjerkehagen, B., Bovee, J. V. M. G., Boye, K., Chacón, Matias, Dei Tos, Angelo Paolo, Desai, Jayesh, Fletcher, Jonathan A., Gelderblom, Hans, George, Suzanne, Gronchi, Alesandro, Haas, R. L., Hindi, Nadia, Hohenberger, Peter, Joensuu, Heikki, Jones, Robin L., Judson, I., Kang, Y.-K., Kawai, Akira, Lazar, A. J., Cesne, Axel Le, Maestro, Roberta, Maki, Robert, Martín, J., Patel, S., Penault-Llorca, F., Premanand Raut, C., Rutkowski, Piotr, Safwat, A. A., Sbaraglia, Marta, Schaefer, I.-M., Shen, L., Serrano, C., Schöffski, P., Stacchiotti, Silvia, Sundby Hall, K., Tap, William D., Thomas, David M., Trent, J., Valverde, Claudia M., Graaf, W.T.A. van der, Mehren, M. von, Wagner, Andrew J., Wardelmann, Eva, Naito, Y., Zalcberg, J., Blay, Jean-Yves
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2020
País:	España
Institución:	Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:	DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:	oai:digital.csic.es:10261/237365
Acceso en línea:	http://hdl.handle.net/10261/237365
Access Level:	acceso abierto
Palabra clave:	Entrectinib Larotrectinib Neurotrophic tyrosine receptor kinase Sarcoma Tropomyosin receptor kinase

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spelling	Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma NetworkDemetri, G. D.Antonescu, Cristina R.Bjerkehagen, B.Bovee, J. V. M. G.Boye, K.Chacón, MatiasDei Tos, Angelo PaoloDesai, JayeshFletcher, Jonathan A.Gelderblom, HansGeorge, SuzanneGronchi, AlesandroHaas, R. L.Hindi, NadiaHohenberger, PeterJoensuu, HeikkiJones, Robin L.Judson, I.Kang, Y.-K.Kawai, AkiraLazar, A. J.Cesne, Axel LeMaestro, RobertaMaki, RobertMartín, J.Patel, S.Penault-Llorca, F.Premanand Raut, C.Rutkowski, PiotrSafwat, A. A.Sbaraglia, MartaSchaefer, I.-M.Shen, L.Serrano, C.Schöffski, P.Stacchiotti, SilviaSundby Hall, K.Tap, William D.Thomas, David M.Trent, J.Valverde, Claudia M.Graaf, W.T.A. van derMehren, M. vonWagner, Andrew J.Wardelmann, EvaNaito, Y.Zalcberg, J.Blay, Jean-YvesEntrectinibLarotrectinibNeurotrophic tyrosine receptor kinaseSarcomaTropomyosin receptor kinase© 2020 The Author(s).Sarcomas are a heterogeneous group of malignancies with mesenchymal lineage differentiation. The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions as tissue-agnostic oncogenic drivers has led to new personalized therapies for a subset of patients with sarcoma in the form of tropomyosin receptor kinase (TRK) inhibitors. NTRK gene rearrangements and fusion transcripts can be detected with different molecular pathology techniques, while TRK protein expression can be demonstrated with immunohistochemistry. The rarity and diagnostic complexity of NTRK gene fusions raise a number of questions and challenges for clinicians. To address these challenges, the World Sarcoma Network convened two meetings of expert adult oncologists and pathologists and subsequently developed this article to provide practical guidance on the management of patients with sarcoma harboring NTRK gene fusions. We propose a diagnostic strategy that considers disease stage and histologic and molecular subtypes to facilitate routine testing for TRK expression and subsequent testing for NTRK gene fusions.GDD was supported in part by the Ludwig Center at Harvard; the Dr Miriam and Sheldon G. Adelson Medical Research Foundation; and the Pan Mass Challenge (no grant numbers). IMS is supported by the National Institutes of Health/National Cancer Institute (grant number K08 CA241085). JYB was supported by NetSARC (INCA & DGOS) and RREPS (INCA & DGOS), RESOS (INCA & DGOS), EURACAN (EC 739521), LYRICAN (INCA-DGOS-INSERM 12563), LabEx DEvweCAN (ANR-10-LABX-0061), Institut Convergence PLASCAN (17-CONV-0002), RHU4 DEPGYN (ANR-18-RHUS-0009).ElsevierHarvard UniversityAdelson Medical Research FoundationNational Institutes of Health (US)National Cancer Institute (US)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/237365reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1016/j.annonc.2020.08.2232Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2373652026-05-22T06:33:51Z
dc.title.none.fl_str_mv	Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network
title	Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network
spellingShingle	Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network Demetri, G. D. Entrectinib Larotrectinib Neurotrophic tyrosine receptor kinase Sarcoma Tropomyosin receptor kinase
title_short	Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network
title_full	Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network
title_fullStr	Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network
title_full_unstemmed	Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network
title_sort	Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network
dc.creator.none.fl_str_mv	Demetri, G. D. Antonescu, Cristina R. Bjerkehagen, B. Bovee, J. V. M. G. Boye, K. Chacón, Matias Dei Tos, Angelo Paolo Desai, Jayesh Fletcher, Jonathan A. Gelderblom, Hans George, Suzanne Gronchi, Alesandro Haas, R. L. Hindi, Nadia Hohenberger, Peter Joensuu, Heikki Jones, Robin L. Judson, I. Kang, Y.-K. Kawai, Akira Lazar, A. J. Cesne, Axel Le Maestro, Roberta Maki, Robert Martín, J. Patel, S. Penault-Llorca, F. Premanand Raut, C. Rutkowski, Piotr Safwat, A. A. Sbaraglia, Marta Schaefer, I.-M. Shen, L. Serrano, C. Schöffski, P. Stacchiotti, Silvia Sundby Hall, K. Tap, William D. Thomas, David M. Trent, J. Valverde, Claudia M. Graaf, W.T.A. van der Mehren, M. von Wagner, Andrew J. Wardelmann, Eva Naito, Y. Zalcberg, J. Blay, Jean-Yves
author	Demetri, G. D.
author_facet	Demetri, G. D. Antonescu, Cristina R. Bjerkehagen, B. Bovee, J. V. M. G. Boye, K. Chacón, Matias Dei Tos, Angelo Paolo Desai, Jayesh Fletcher, Jonathan A. Gelderblom, Hans George, Suzanne Gronchi, Alesandro Haas, R. L. Hindi, Nadia Hohenberger, Peter Joensuu, Heikki Jones, Robin L. Judson, I. Kang, Y.-K. Kawai, Akira Lazar, A. J. Cesne, Axel Le Maestro, Roberta Maki, Robert Martín, J. Patel, S. Penault-Llorca, F. Premanand Raut, C. Rutkowski, Piotr Safwat, A. A. Sbaraglia, Marta Schaefer, I.-M. Shen, L. Serrano, C. Schöffski, P. Stacchiotti, Silvia Sundby Hall, K. Tap, William D. Thomas, David M. Trent, J. Valverde, Claudia M. Graaf, W.T.A. van der Mehren, M. von Wagner, Andrew J. Wardelmann, Eva Naito, Y. Zalcberg, J. Blay, Jean-Yves
author_role	author
author2	Antonescu, Cristina R. Bjerkehagen, B. Bovee, J. V. M. G. Boye, K. Chacón, Matias Dei Tos, Angelo Paolo Desai, Jayesh Fletcher, Jonathan A. Gelderblom, Hans George, Suzanne Gronchi, Alesandro Haas, R. L. Hindi, Nadia Hohenberger, Peter Joensuu, Heikki Jones, Robin L. Judson, I. Kang, Y.-K. Kawai, Akira Lazar, A. J. Cesne, Axel Le Maestro, Roberta Maki, Robert Martín, J. Patel, S. Penault-Llorca, F. Premanand Raut, C. Rutkowski, Piotr Safwat, A. A. Sbaraglia, Marta Schaefer, I.-M. Shen, L. Serrano, C. Schöffski, P. Stacchiotti, Silvia Sundby Hall, K. Tap, William D. Thomas, David M. Trent, J. Valverde, Claudia M. Graaf, W.T.A. van der Mehren, M. von Wagner, Andrew J. Wardelmann, Eva Naito, Y. Zalcberg, J. Blay, Jean-Yves
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Harvard University Adelson Medical Research Foundation National Institutes of Health (US) National Cancer Institute (US) Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv	Entrectinib Larotrectinib Neurotrophic tyrosine receptor kinase Sarcoma Tropomyosin receptor kinase
topic	Entrectinib Larotrectinib Neurotrophic tyrosine receptor kinase Sarcoma Tropomyosin receptor kinase
description	© 2020 The Author(s).
publishDate	2020
dc.date.none.fl_str_mv	2020 2021 2021 2021
dc.type.none.fl_str_mv	info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_dcae04bc Publisher's version info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10261/237365
url	http://hdl.handle.net/10261/237365
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	http://dx.doi.org/10.1016/j.annonc.2020.08.2232 Sí
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str	Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str	DIGITAL.CSIC. Repositorio Institucional del CSIC
collection	DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,81155

Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network

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