The diffuse endocrine system: from embryogenesis to carcinogenesis
In the present review we will summarise the current knowledge about the cells comprising the Diffuse Endocrine System (DES) in mammalian organs. We will describe the morphological, histochemical and functional traits of these cells in three major systems gastrointestinal, respiratory and prostatic....
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2003 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/20181 |
| Acceso en línea: | https://hdl.handle.net/10171/20181 |
| Access Level: | acceso abierto |
| Palabra clave: | APUD cells Carcinogenesis Carcinoids Diffuse endocrine system Diffuse neuroendocrine system Gastroenteropancreatic diffuse endocrine system Neuroendocrine tumors Paraneurons Peptide secreting cells Prostate neuroendocrine cells Pulmonary diffuse endocrine system |
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The diffuse endocrine system: from embryogenesis to carcinogenesisMontuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596Guembe-Echarri, L. (Laura)|||/items/97f8ce8d-95cd-4a82-9a07-254d1f89f0e6Burrell, M.A. (María Ángela)|||/items/27fe7d6b-4d2b-4917-91af-68de4749f75bBodegas-Frías, M.E. (María Elena)|||/items/d91f92cf-206e-4b2d-a5fd-74db7fafa56aCalvo-González, A. (Alfonso)|||/items/ac176653-87d5-476b-b2b9-ade455cfa6deSola, J.J. (Jesús Javier)|||/items/5e9c3448-a06b-4c18-ac7a-1f314af02493Sesma, M.P. (María Pilar)|||/items/52ce24fb-7c31-4e26-803c-91fdbf46aff0Villaro, A.C. (Ana Cristina)|||/items/b0875a7d-710f-4d3e-85c5-be2e47ae5119APUD cellsCarcinogenesisCarcinoidsDiffuse endocrine systemDiffuse neuroendocrine systemGastroenteropancreatic diffuse endocrine systemNeuroendocrine tumorsParaneuronsPeptide secreting cellsProstate neuroendocrine cellsPulmonary diffuse endocrine systemIn the present review we will summarise the current knowledge about the cells comprising the Diffuse Endocrine System (DES) in mammalian organs. We will describe the morphological, histochemical and functional traits of these cells in three major systems gastrointestinal, respiratory and prostatic. We will also focus on some aspects of their ontogeny and differentiation, as well as to their relevance in carcinogenesis, especially in neuroendocrine tumors. The first chapter describes the characteristics of DES cells and some of their specific biological and biochemical traits. The second chapter deals with DES in the gastrointestinal organs, with special reference to the new data on the differentiation mechanisms that leads to the appearance of endocrine cells from an undifferentiated stem cell. The third chapter is devoted to DES of the respiratory system and some aspects of its biological role, both, during development and adulthood. Neuroendocrine hyperplasia and neuroendocrine lung tumors are also addressed. Finally, the last chapter deals with the prostatic DES, discussing its probable functional role and its relevance in hormone-resistant prostatic carcinomas.ElsevierDadun. Depósito Académico Digital Universidad de Navarra20112011-12-1220032003-01-0120032003-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/20181reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/201812026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
The diffuse endocrine system: from embryogenesis to carcinogenesis |
| title |
The diffuse endocrine system: from embryogenesis to carcinogenesis |
| spellingShingle |
The diffuse endocrine system: from embryogenesis to carcinogenesis Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596 APUD cells Carcinogenesis Carcinoids Diffuse endocrine system Diffuse neuroendocrine system Gastroenteropancreatic diffuse endocrine system Neuroendocrine tumors Paraneurons Peptide secreting cells Prostate neuroendocrine cells Pulmonary diffuse endocrine system |
| title_short |
The diffuse endocrine system: from embryogenesis to carcinogenesis |
| title_full |
The diffuse endocrine system: from embryogenesis to carcinogenesis |
| title_fullStr |
The diffuse endocrine system: from embryogenesis to carcinogenesis |
| title_full_unstemmed |
The diffuse endocrine system: from embryogenesis to carcinogenesis |
| title_sort |
The diffuse endocrine system: from embryogenesis to carcinogenesis |
| dc.creator.none.fl_str_mv |
Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596 Guembe-Echarri, L. (Laura)|||/items/97f8ce8d-95cd-4a82-9a07-254d1f89f0e6 Burrell, M.A. (María Ángela)|||/items/27fe7d6b-4d2b-4917-91af-68de4749f75b Bodegas-Frías, M.E. (María Elena)|||/items/d91f92cf-206e-4b2d-a5fd-74db7fafa56a Calvo-González, A. (Alfonso)|||/items/ac176653-87d5-476b-b2b9-ade455cfa6de Sola, J.J. (Jesús Javier)|||/items/5e9c3448-a06b-4c18-ac7a-1f314af02493 Sesma, M.P. (María Pilar)|||/items/52ce24fb-7c31-4e26-803c-91fdbf46aff0 Villaro, A.C. (Ana Cristina)|||/items/b0875a7d-710f-4d3e-85c5-be2e47ae5119 |
| author |
Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596 |
| author_facet |
Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596 Guembe-Echarri, L. (Laura)|||/items/97f8ce8d-95cd-4a82-9a07-254d1f89f0e6 Burrell, M.A. (María Ángela)|||/items/27fe7d6b-4d2b-4917-91af-68de4749f75b Bodegas-Frías, M.E. (María Elena)|||/items/d91f92cf-206e-4b2d-a5fd-74db7fafa56a Calvo-González, A. (Alfonso)|||/items/ac176653-87d5-476b-b2b9-ade455cfa6de Sola, J.J. (Jesús Javier)|||/items/5e9c3448-a06b-4c18-ac7a-1f314af02493 Sesma, M.P. (María Pilar)|||/items/52ce24fb-7c31-4e26-803c-91fdbf46aff0 Villaro, A.C. (Ana Cristina)|||/items/b0875a7d-710f-4d3e-85c5-be2e47ae5119 |
| author_role |
author |
| author2 |
Guembe-Echarri, L. (Laura)|||/items/97f8ce8d-95cd-4a82-9a07-254d1f89f0e6 Burrell, M.A. (María Ángela)|||/items/27fe7d6b-4d2b-4917-91af-68de4749f75b Bodegas-Frías, M.E. (María Elena)|||/items/d91f92cf-206e-4b2d-a5fd-74db7fafa56a Calvo-González, A. (Alfonso)|||/items/ac176653-87d5-476b-b2b9-ade455cfa6de Sola, J.J. (Jesús Javier)|||/items/5e9c3448-a06b-4c18-ac7a-1f314af02493 Sesma, M.P. (María Pilar)|||/items/52ce24fb-7c31-4e26-803c-91fdbf46aff0 Villaro, A.C. (Ana Cristina)|||/items/b0875a7d-710f-4d3e-85c5-be2e47ae5119 |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
APUD cells Carcinogenesis Carcinoids Diffuse endocrine system Diffuse neuroendocrine system Gastroenteropancreatic diffuse endocrine system Neuroendocrine tumors Paraneurons Peptide secreting cells Prostate neuroendocrine cells Pulmonary diffuse endocrine system |
| topic |
APUD cells Carcinogenesis Carcinoids Diffuse endocrine system Diffuse neuroendocrine system Gastroenteropancreatic diffuse endocrine system Neuroendocrine tumors Paraneurons Peptide secreting cells Prostate neuroendocrine cells Pulmonary diffuse endocrine system |
| description |
In the present review we will summarise the current knowledge about the cells comprising the Diffuse Endocrine System (DES) in mammalian organs. We will describe the morphological, histochemical and functional traits of these cells in three major systems gastrointestinal, respiratory and prostatic. We will also focus on some aspects of their ontogeny and differentiation, as well as to their relevance in carcinogenesis, especially in neuroendocrine tumors. The first chapter describes the characteristics of DES cells and some of their specific biological and biochemical traits. The second chapter deals with DES in the gastrointestinal organs, with special reference to the new data on the differentiation mechanisms that leads to the appearance of endocrine cells from an undifferentiated stem cell. The third chapter is devoted to DES of the respiratory system and some aspects of its biological role, both, during development and adulthood. Neuroendocrine hyperplasia and neuroendocrine lung tumors are also addressed. Finally, the last chapter deals with the prostatic DES, discussing its probable functional role and its relevance in hormone-resistant prostatic carcinomas. |
| publishDate |
2003 |
| dc.date.none.fl_str_mv |
2003 2003-01-01 2003 2003-01-01 2011 2011-12-12 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/20181 |
| url |
https://hdl.handle.net/10171/20181 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
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Elsevier |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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15,300719 |