Severity Scores in COVID-19 Pneumonia: a Multicenter, Retrospective, Cohort Study

Background Identification of patients on admission to hospital with coronavirus infectious disease 2019 (COVID-19) pneumonia who can develop poor outcomes has not yet been comprehensively assessed. Objective To compare severity scores used for community-acquired pneumonia to identify high-risk patie...

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Autores: Artero A, Madrazo M, Fernández-Garcés M, Muiño Miguez A, González García A, Crestelo Vieitez A, García Guijarro E, Fonseca Aizpuru EM, García Gómez M, Areses Manrique M, Martinez Cilleros C, Fidalgo Moreno MDP, Loureiro Amigo J, Gil Sánchez R, Rabadán Pejenaute E, Abella Vázquez L, Cañizares Navarro R, Solís Marquínez MN, Carrasco Sánchez FJ, González Moraleja J, Montero Rivas L, Escobar Sevilla J, Martín Escalante MD, Gómez-Huelgas R, SEMI-COVID-19 Network
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositório:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p8945
Acesso em linha:https://fisabio.portalinvestigacion.com/publicaciones/8945
Access Level:Acceso aberto
Palavra-chave:CURB-65
PSI
qSOFA
COVID-19
community-acquired pneumonia
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spelling Severity Scores in COVID-19 Pneumonia: a Multicenter, Retrospective, Cohort StudyArtero AMadrazo MFernández-Garcés MMuiño Miguez AGonzález García ACrestelo Vieitez AGarcía Guijarro EFonseca Aizpuru EMGarcía Gómez MAreses Manrique MMartinez Cilleros CFidalgo Moreno MDPLoureiro Amigo JGil Sánchez RRabadán Pejenaute EAbella Vázquez LCañizares Navarro RSolís Marquínez MNCarrasco Sánchez FJGonzález Moraleja JMontero Rivas LEscobar Sevilla JMartín Escalante MDGómez-Huelgas RSEMI-COVID-19 NetworkCURB-65PSIqSOFACOVID-19community-acquired pneumoniaBackground Identification of patients on admission to hospital with coronavirus infectious disease 2019 (COVID-19) pneumonia who can develop poor outcomes has not yet been comprehensively assessed. Objective To compare severity scores used for community-acquired pneumonia to identify high-risk patients with COVID-19 pneumonia. Design PSI, CURB-65, qSOFA, and MuLBSTA, a new score for viral pneumonia, were calculated on admission to hospital to identify high-risk patients for in-hospital mortality, admission to an intensive care unit (ICU), or use of mechanical ventilation. Area under receiver operating characteristics curve (AUROC), sensitivity, and specificity for each score were determined and AUROC was compared among them. Participants Patients with COVID-19 pneumonia included in the SEMI-COVID-19 Network. Key results We examined 10,238 patients with COVID-19. Mean age of patients was 66.6 years and 57.9% were males. The most common comorbidities were as follows: hypertension (49.2%), diabetes (18.8%), and chronic obstructive pulmonary disease (12.8%). Acute respiratory distress syndrome (34.7%) and acute kidney injury (13.9%) were the most common complications. In-hospital mortality was 20.9%. PSI and CURB-65 showed the highest AUROC (0.835 and 0.825, respectively). qSOFA and MuLBSTA had a lower AUROC (0.728 and 0.715, respectively). qSOFA was the most specific score (specificity 95.7%) albeit its sensitivity was only 26.2%. PSI had the highest sensitivity (84.1%) and a specificity of 72.2%. Conclusions PSI and CURB-65, specific severity scores for pneumonia, were better than qSOFA and MuLBSTA at predicting mortality in patients with COVID-19 pneumonia. Additionally, qSOFA, the simplest score to perform, was the most specific albeit the least sensitive.Springer Verlag2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/8945JOURNAL OF GENERAL INTERNAL MEDICINEISSN: 15251497ISSNe: 08848734reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p89452026-06-11T12:45:17Z
dc.title.none.fl_str_mv Severity Scores in COVID-19 Pneumonia: a Multicenter, Retrospective, Cohort Study
title Severity Scores in COVID-19 Pneumonia: a Multicenter, Retrospective, Cohort Study
spellingShingle Severity Scores in COVID-19 Pneumonia: a Multicenter, Retrospective, Cohort Study
Artero A
CURB-65
PSI
qSOFA
COVID-19
community-acquired pneumonia
title_short Severity Scores in COVID-19 Pneumonia: a Multicenter, Retrospective, Cohort Study
title_full Severity Scores in COVID-19 Pneumonia: a Multicenter, Retrospective, Cohort Study
title_fullStr Severity Scores in COVID-19 Pneumonia: a Multicenter, Retrospective, Cohort Study
title_full_unstemmed Severity Scores in COVID-19 Pneumonia: a Multicenter, Retrospective, Cohort Study
title_sort Severity Scores in COVID-19 Pneumonia: a Multicenter, Retrospective, Cohort Study
dc.creator.none.fl_str_mv Artero A
Madrazo M
Fernández-Garcés M
Muiño Miguez A
González García A
Crestelo Vieitez A
García Guijarro E
Fonseca Aizpuru EM
García Gómez M
Areses Manrique M
Martinez Cilleros C
Fidalgo Moreno MDP
Loureiro Amigo J
Gil Sánchez R
Rabadán Pejenaute E
Abella Vázquez L
Cañizares Navarro R
Solís Marquínez MN
Carrasco Sánchez FJ
González Moraleja J
Montero Rivas L
Escobar Sevilla J
Martín Escalante MD
Gómez-Huelgas R
SEMI-COVID-19 Network
author Artero A
author_facet Artero A
Madrazo M
Fernández-Garcés M
Muiño Miguez A
González García A
Crestelo Vieitez A
García Guijarro E
Fonseca Aizpuru EM
García Gómez M
Areses Manrique M
Martinez Cilleros C
Fidalgo Moreno MDP
Loureiro Amigo J
Gil Sánchez R
Rabadán Pejenaute E
Abella Vázquez L
Cañizares Navarro R
Solís Marquínez MN
Carrasco Sánchez FJ
González Moraleja J
Montero Rivas L
Escobar Sevilla J
Martín Escalante MD
Gómez-Huelgas R
SEMI-COVID-19 Network
author_role author
author2 Madrazo M
Fernández-Garcés M
Muiño Miguez A
González García A
Crestelo Vieitez A
García Guijarro E
Fonseca Aizpuru EM
García Gómez M
Areses Manrique M
Martinez Cilleros C
Fidalgo Moreno MDP
Loureiro Amigo J
Gil Sánchez R
Rabadán Pejenaute E
Abella Vázquez L
Cañizares Navarro R
Solís Marquínez MN
Carrasco Sánchez FJ
González Moraleja J
Montero Rivas L
Escobar Sevilla J
Martín Escalante MD
Gómez-Huelgas R
SEMI-COVID-19 Network
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CURB-65
PSI
qSOFA
COVID-19
community-acquired pneumonia
topic CURB-65
PSI
qSOFA
COVID-19
community-acquired pneumonia
description Background Identification of patients on admission to hospital with coronavirus infectious disease 2019 (COVID-19) pneumonia who can develop poor outcomes has not yet been comprehensively assessed. Objective To compare severity scores used for community-acquired pneumonia to identify high-risk patients with COVID-19 pneumonia. Design PSI, CURB-65, qSOFA, and MuLBSTA, a new score for viral pneumonia, were calculated on admission to hospital to identify high-risk patients for in-hospital mortality, admission to an intensive care unit (ICU), or use of mechanical ventilation. Area under receiver operating characteristics curve (AUROC), sensitivity, and specificity for each score were determined and AUROC was compared among them. Participants Patients with COVID-19 pneumonia included in the SEMI-COVID-19 Network. Key results We examined 10,238 patients with COVID-19. Mean age of patients was 66.6 years and 57.9% were males. The most common comorbidities were as follows: hypertension (49.2%), diabetes (18.8%), and chronic obstructive pulmonary disease (12.8%). Acute respiratory distress syndrome (34.7%) and acute kidney injury (13.9%) were the most common complications. In-hospital mortality was 20.9%. PSI and CURB-65 showed the highest AUROC (0.835 and 0.825, respectively). qSOFA and MuLBSTA had a lower AUROC (0.728 and 0.715, respectively). qSOFA was the most specific score (specificity 95.7%) albeit its sensitivity was only 26.2%. PSI had the highest sensitivity (84.1%) and a specificity of 72.2%. Conclusions PSI and CURB-65, specific severity scores for pneumonia, were better than qSOFA and MuLBSTA at predicting mortality in patients with COVID-19 pneumonia. Additionally, qSOFA, the simplest score to perform, was the most specific albeit the least sensitive.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/8945
url https://fisabio.portalinvestigacion.com/publicaciones/8945
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv JOURNAL OF GENERAL INTERNAL MEDICINE
ISSN: 15251497
ISSNe: 08848734
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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