Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy

Purpose: To characterise brain lesions in dyskinetic cerebral palsy (DCP) using the semi-quantitative scale for structural MRI (sqMRI) and to investigate their relationship with motor, communication and cognitive function. Materials and methods: Thirty-nine participants (19 females, median age 21y)...

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Autores: Laporta-Hoyos, Olga, Fiori, Simona, Pannek, Kerstin, Ballester Plané, Júlia, Leiva Ureña, David, Reid, Lee, Pagnozzi, Alex M., Vázquez, Elida, Delgado, Ignacio, Macaya Ruiz, Alfons, Pueyo Benito, Roser, Boyd, Roslyn
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/207100
Acceso en línea:https://hdl.handle.net/2445/207100
Access Level:acceso abierto
Palabra clave:Paràlisi cerebral
Imatges per ressonància magnètica
Cognició
Lesions cerebrals
Cerebral palsy
Magnetic resonance imaging
Cognition
Brain damage
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spelling Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsyLaporta-Hoyos, OlgaFiori, SimonaPannek, KerstinBallester Plané, JúliaLeiva Ureña, DavidReid, LeePagnozzi, Alex M.Vázquez, ElidaDelgado, IgnacioMacaya Ruiz, AlfonsPueyo Benito, RoserBoyd, RoslynParàlisi cerebralImatges per ressonància magnèticaCognicióLesions cerebralsCerebral palsyMagnetic resonance imagingCognitionBrain damagePurpose: To characterise brain lesions in dyskinetic cerebral palsy (DCP) using the semi-quantitative scale for structural MRI (sqMRI) and to investigate their relationship with motor, communication and cognitive function. Materials and methods: Thirty-nine participants (19 females, median age 21y) with DCP were assessed in terms of motor function, communication and a variety of cognitive domains. Whole-head magnetic resonance imaging (MRI) was performed including T1-MPRAGE, T2 turbo spin echo (axial plane), and fluid attenuated inversion recovery images (FLAIR). A child neurologist visually assessed images for brain lesions and scored these using the sqMRI. Ordinal, Poisson and binomial negative regression models identified which brain lesions accounted for clinical outcomes. Results: Brain lesions were most frequently located in the ventral posterior lateral thalamus and the frontal lobe. Gross (B = 0.180, p < .001; B = 0.658, p < .001) and fine (B = 0.136, p = .003; B = 0.540, p < .001) motor function were associated with global sqMRI score and parietal involvement. Communication functioning was associated with putamen involvement (B = 0.747, p < .028). Intellectual functioning was associated with global sqMRI score and posterior thalamus involvement (B = -0.018, p < .001; B = -0.192, p < .001). Selective attention was associated with global sqMRI score (B = -0.035, p < .001), parietal (B = -0.063, p = .023), and corpus callosum involvement (B = -0.448, p < .001). Visuospatial and visuoperceptive abilities were associated with global sqMRI score (B = -0.078, p = .007) and medial dorsal thalamus involvement (B = -0.139, p < .012), respectively. Conclusions: Key clinical outcomes in DCP are associated with specific observable brain lesions as indexed by a simple lesion scoring system that relies only on standard clinical MRI.Elsevier2024202420182024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfhttps://hdl.handle.net/2445/207100Articles publicats en revistes (Psicologia Clínica i Psicobiologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.nicl.2018.06.015Neuroimage-Clinical, 2018, vol. 19, p. 892-900https://doi.org/10.1016/j.nicl.2018.06.015cc-by-nc-nd (c) Elsevier, 2018http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2071002026-05-29T05:05:01Z
dc.title.none.fl_str_mv Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy
title Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy
spellingShingle Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy
Laporta-Hoyos, Olga
Paràlisi cerebral
Imatges per ressonància magnètica
Cognició
Lesions cerebrals
Cerebral palsy
Magnetic resonance imaging
Cognition
Brain damage
title_short Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy
title_full Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy
title_fullStr Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy
title_full_unstemmed Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy
title_sort Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy
dc.creator.none.fl_str_mv Laporta-Hoyos, Olga
Fiori, Simona
Pannek, Kerstin
Ballester Plané, Júlia
Leiva Ureña, David
Reid, Lee
Pagnozzi, Alex M.
Vázquez, Elida
Delgado, Ignacio
Macaya Ruiz, Alfons
Pueyo Benito, Roser
Boyd, Roslyn
author Laporta-Hoyos, Olga
author_facet Laporta-Hoyos, Olga
Fiori, Simona
Pannek, Kerstin
Ballester Plané, Júlia
Leiva Ureña, David
Reid, Lee
Pagnozzi, Alex M.
Vázquez, Elida
Delgado, Ignacio
Macaya Ruiz, Alfons
Pueyo Benito, Roser
Boyd, Roslyn
author_role author
author2 Fiori, Simona
Pannek, Kerstin
Ballester Plané, Júlia
Leiva Ureña, David
Reid, Lee
Pagnozzi, Alex M.
Vázquez, Elida
Delgado, Ignacio
Macaya Ruiz, Alfons
Pueyo Benito, Roser
Boyd, Roslyn
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Paràlisi cerebral
Imatges per ressonància magnètica
Cognició
Lesions cerebrals
Cerebral palsy
Magnetic resonance imaging
Cognition
Brain damage
topic Paràlisi cerebral
Imatges per ressonància magnètica
Cognició
Lesions cerebrals
Cerebral palsy
Magnetic resonance imaging
Cognition
Brain damage
description Purpose: To characterise brain lesions in dyskinetic cerebral palsy (DCP) using the semi-quantitative scale for structural MRI (sqMRI) and to investigate their relationship with motor, communication and cognitive function. Materials and methods: Thirty-nine participants (19 females, median age 21y) with DCP were assessed in terms of motor function, communication and a variety of cognitive domains. Whole-head magnetic resonance imaging (MRI) was performed including T1-MPRAGE, T2 turbo spin echo (axial plane), and fluid attenuated inversion recovery images (FLAIR). A child neurologist visually assessed images for brain lesions and scored these using the sqMRI. Ordinal, Poisson and binomial negative regression models identified which brain lesions accounted for clinical outcomes. Results: Brain lesions were most frequently located in the ventral posterior lateral thalamus and the frontal lobe. Gross (B = 0.180, p < .001; B = 0.658, p < .001) and fine (B = 0.136, p = .003; B = 0.540, p < .001) motor function were associated with global sqMRI score and parietal involvement. Communication functioning was associated with putamen involvement (B = 0.747, p < .028). Intellectual functioning was associated with global sqMRI score and posterior thalamus involvement (B = -0.018, p < .001; B = -0.192, p < .001). Selective attention was associated with global sqMRI score (B = -0.035, p < .001), parietal (B = -0.063, p = .023), and corpus callosum involvement (B = -0.448, p < .001). Visuospatial and visuoperceptive abilities were associated with global sqMRI score (B = -0.078, p = .007) and medial dorsal thalamus involvement (B = -0.139, p < .012), respectively. Conclusions: Key clinical outcomes in DCP are associated with specific observable brain lesions as indexed by a simple lesion scoring system that relies only on standard clinical MRI.
publishDate 2018
dc.date.none.fl_str_mv 2018
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/207100
url https://hdl.handle.net/2445/207100
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.nicl.2018.06.015
Neuroimage-Clinical, 2018, vol. 19, p. 892-900
https://doi.org/10.1016/j.nicl.2018.06.015
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier, 2018
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier, 2018
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Psicologia Clínica i Psicobiologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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