Ultra-low dose whole-body CT for attenuation correction in a dual tracer PET/CT protocol for multiple myeloma

Purpose: To investigate within phantoms the minimum CT dose allowed for accurate attenuation correction of PET data and to quantify the effective dose reduction when a CT for this purpose is incorporated in the clinical setting. Methods: The NEMA image quality phantom was scanned within a large para...

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Authors: Prieto-Azcárate, E. (Elena)|||/items/98983a2a-3ce1-471b-8174-68cd47fc9fcb, Garcia-Velloso, M. J. (María José)|||/items/95484946-2b37-4f2a-943f-fc76c5b2aa8b, Aquerreta-Beola, J.D. (Jesús Dámaso)|||/items/4e22c489-21cd-439a-808b-498365a8e461, Rosales-Castillo, J.J. (Juan José)|||/items/1463754f-fd85-40be-a49d-9cedf0c94413, Bastidas, J.F. (Juan Fernando)|||/items/72e7eb11-4a76-4a34-8240-aafd0be7a676, Soriano, I. (Ignacio)|||/items/38b1af95-3525-4dad-8fd2-cfa59ba5ea69, Irazola, L. (Leticia)|||/items/27cef783-4ce8-4049-a487-9e1bccbcdad9, Rodriguez-Otero, P. (Paula)|||/items/bb21b679-c3ea-4d5a-9939-f330219406c8, Quincoces-Fernández, G. (Gemma)|||/items/fa93ac37-c637-4dad-be78-c9a892ebb80d, Marti-Climent, J.M. (Josep María)|||/items/dfc511a4-aa92-44b5-8624-17b03d0f3466
Format: article
Publication Date:2021
Country:España
Institution:Universidad de Navarra
Repository:Dadun. Depósito Académico Digital de la Universidad de Navarra
Language:English
OAI Identifier:oai:dadun.unav.edu:10171/63583
Online Access:https://hdl.handle.net/10171/63583
Access Level:Open access
Keyword:PET/CT
Radiation dose
Optimization
Multiple myeloma
Description
Summary:Purpose: To investigate within phantoms the minimum CT dose allowed for accurate attenuation correction of PET data and to quantify the effective dose reduction when a CT for this purpose is incorporated in the clinical setting. Methods: The NEMA image quality phantom was scanned within a large parallelepiped container. Twenty-one different CT images were acquired to correct attenuation of PET raw data. Radiation dose and image quality were evaluated. Thirty-one patients with proven multiple myeloma who underwent a dual tracer PET/CT scan were retrospec- tively reviewed. 18F-fluorodeoxyglucose PET/CT included a diagnostic whole-body low dose CT (WBLDCT: 120 kV-80mAs) and 11C-Methionine PET/CT included a whole-body ultra-low dose CT (WBULDCT) for attenuation correction (100 kV-40mAs). Effective dose and image quality were analysed. Results: Only the two lowest radiation dose conditions (80 kV-20mAs and 80 kV-10mAs) produced artifacts in CT images that degraded corrected PET images. For all the other conditions (CTDIvol ≥ 0.43 mGy), PET contrast recovery coefficients varied less than ± 1.2%. Patients received a median dose of 6.4 mSv from diagnostic CT and 2.1 mSv from the attenuation correction CT. Despite the worse image quality of this CT, 94.8% of bone lesions were identifiable. Conclusion: Phantom experiments showed that an ultra-low dose CT can be implemented in PET/CT procedures without any noticeable degradation in the attenuation corrected PET scan. The replacement of the standard CT for this ultra-low dose CT in clinical PET/CT scans involves a significant radiation dose reduction

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