Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue.
Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/15783 |
| Acceso en línea: | http://hdl.handle.net/20.500.12105/15783 |
| Access Level: | acceso abierto |
| Palabra clave: | Insulin Resistance Adipose Tissue Animals Homeostasis Intra-Abdominal Fat Mice Obesity Proteomics |
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Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue.Gonzalez-Franquesa, AlbaGama-Perez, PauKulis, MartaSzczepanowska, KarolinaDahdah, NormaMoreno-Gomez, SoniaLatorre-Pellicer, AnaFernández-Ruiz, RebecaAguilar-Mogas, AntoniHoffman, AnneMonelli, ErikaSamino, SaraMiró-Blanch, JoanOemer, GregorDuran, XavierSanchez-Rebordelo, EstrellaSchneeberger, MarcObach, MerceMontane, JoelCastellano, GiancarloChapaprieta, VicenteSun, WenfeiNavarro, LourdesPrieto, IgnacioCastaño, CarlosNovials, AnnaGomis, RamonMonsalve, MariaClaret, MarcGraupera, MarionaSoria, GuadalupeWolfrum, ChristianVendrell, JoanFernández-Veledo, SoniaEnriquez, Jose AntonioCarracedo, AngelPerales, José CarlosNogueiras, RubénHerrero, LauraTrifunovic, AleksandraKeller, Markus AYanes, OscarSales-Pardo, MartaGuimerà, RogerBlüher, MatthiasMartín-Subero, José IgnacioGarcia-Roves, Pablo MInsulin ResistanceAdipose TissueAnimalsHomeostasisIntra-Abdominal FatMiceObesityProteomicsMetabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue.ElsevierMinisterio de Ciencia e Innovación (España)Instituto de Salud Carlos IIIUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)Government of Catalonia (España)Ministerio de Economía, Innovación y Competitividad (España)Unión Europea. Comisión Europea. European Research Council (ERC)Unión Europea. Comisión Europea. H2020Centro de Investigación Biomédica en Red - CIBEROBN (Fisiopatología de la Obesidad y Nutrición)Fundación La Marató TV3Novo Nordisk FoundationFundación Alicia Koplowitz20232023-04-1220222022-08-0120222022-08-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/15783reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme ERCopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/157832026-06-12T12:43:37Z |
| dc.title.none.fl_str_mv |
Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. |
| title |
Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. |
| spellingShingle |
Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. Gonzalez-Franquesa, Alba Insulin Resistance Adipose Tissue Animals Homeostasis Intra-Abdominal Fat Mice Obesity Proteomics |
| title_short |
Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. |
| title_full |
Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. |
| title_fullStr |
Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. |
| title_full_unstemmed |
Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. |
| title_sort |
Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. |
| dc.creator.none.fl_str_mv |
Gonzalez-Franquesa, Alba Gama-Perez, Pau Kulis, Marta Szczepanowska, Karolina Dahdah, Norma Moreno-Gomez, Sonia Latorre-Pellicer, Ana Fernández-Ruiz, Rebeca Aguilar-Mogas, Antoni Hoffman, Anne Monelli, Erika Samino, Sara Miró-Blanch, Joan Oemer, Gregor Duran, Xavier Sanchez-Rebordelo, Estrella Schneeberger, Marc Obach, Merce Montane, Joel Castellano, Giancarlo Chapaprieta, Vicente Sun, Wenfei Navarro, Lourdes Prieto, Ignacio Castaño, Carlos Novials, Anna Gomis, Ramon Monsalve, Maria Claret, Marc Graupera, Mariona Soria, Guadalupe Wolfrum, Christian Vendrell, Joan Fernández-Veledo, Sonia Enriquez, Jose Antonio Carracedo, Angel Perales, José Carlos Nogueiras, Rubén Herrero, Laura Trifunovic, Aleksandra Keller, Markus A Yanes, Oscar Sales-Pardo, Marta Guimerà, Roger Blüher, Matthias Martín-Subero, José Ignacio Garcia-Roves, Pablo M |
| author |
Gonzalez-Franquesa, Alba |
| author_facet |
Gonzalez-Franquesa, Alba Gama-Perez, Pau Kulis, Marta Szczepanowska, Karolina Dahdah, Norma Moreno-Gomez, Sonia Latorre-Pellicer, Ana Fernández-Ruiz, Rebeca Aguilar-Mogas, Antoni Hoffman, Anne Monelli, Erika Samino, Sara Miró-Blanch, Joan Oemer, Gregor Duran, Xavier Sanchez-Rebordelo, Estrella Schneeberger, Marc Obach, Merce Montane, Joel Castellano, Giancarlo Chapaprieta, Vicente Sun, Wenfei Navarro, Lourdes Prieto, Ignacio Castaño, Carlos Novials, Anna Gomis, Ramon Monsalve, Maria Claret, Marc Graupera, Mariona Soria, Guadalupe Wolfrum, Christian Vendrell, Joan Fernández-Veledo, Sonia Enriquez, Jose Antonio Carracedo, Angel Perales, José Carlos Nogueiras, Rubén Herrero, Laura Trifunovic, Aleksandra Keller, Markus A Yanes, Oscar Sales-Pardo, Marta Guimerà, Roger Blüher, Matthias Martín-Subero, José Ignacio Garcia-Roves, Pablo M |
| author_role |
author |
| author2 |
Gama-Perez, Pau Kulis, Marta Szczepanowska, Karolina Dahdah, Norma Moreno-Gomez, Sonia Latorre-Pellicer, Ana Fernández-Ruiz, Rebeca Aguilar-Mogas, Antoni Hoffman, Anne Monelli, Erika Samino, Sara Miró-Blanch, Joan Oemer, Gregor Duran, Xavier Sanchez-Rebordelo, Estrella Schneeberger, Marc Obach, Merce Montane, Joel Castellano, Giancarlo Chapaprieta, Vicente Sun, Wenfei Navarro, Lourdes Prieto, Ignacio Castaño, Carlos Novials, Anna Gomis, Ramon Monsalve, Maria Claret, Marc Graupera, Mariona Soria, Guadalupe Wolfrum, Christian Vendrell, Joan Fernández-Veledo, Sonia Enriquez, Jose Antonio Carracedo, Angel Perales, José Carlos Nogueiras, Rubén Herrero, Laura Trifunovic, Aleksandra Keller, Markus A Yanes, Oscar Sales-Pardo, Marta Guimerà, Roger Blüher, Matthias Martín-Subero, José Ignacio Garcia-Roves, Pablo M |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Ministerio de Ciencia e Innovación (España) Instituto de Salud Carlos III Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) Government of Catalonia (España) Ministerio de Economía, Innovación y Competitividad (España) Unión Europea. Comisión Europea. European Research Council (ERC) Unión Europea. Comisión Europea. H2020 Centro de Investigación Biomédica en Red - CIBEROBN (Fisiopatología de la Obesidad y Nutrición) Fundación La Marató TV3 Novo Nordisk Foundation Fundación Alicia Koplowitz |
| dc.subject.none.fl_str_mv |
Insulin Resistance Adipose Tissue Animals Homeostasis Intra-Abdominal Fat Mice Obesity Proteomics |
| topic |
Insulin Resistance Adipose Tissue Animals Homeostasis Intra-Abdominal Fat Mice Obesity Proteomics |
| description |
Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 2022-08-01 2022 2022-08-01 2023 2023-04-12 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12105/15783 |
| url |
http://hdl.handle.net/20.500.12105/15783 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme ERC |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII) |
| instname_str |
Instituto de Salud Carlos III (ISCIII) |
| reponame_str |
Repisalud |
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Repisalud |
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|
| repository.mail.fl_str_mv |
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1869407512291180544 |
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15.81155 |