Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance

Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 7...

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Detalhes bibliográficos
Autores: Munk, Patrick, Brinch, Christian, Møller, Frederik Duus, Petersen, Thomas N., Hendriksen, Rene S., Seyfarth, Anne Mette, Kjeldgaard, Jette S., Svendsen, Christina Aaby, van Bunnik, Bram, Berglund, Fanny, Global Sewage Surveillance Consortium, Cerdà-Cuéllar, Marta, Larsson, D. G. Joakim, Koopmans, Marion, Woolhouse, Mark, Aarestrup, Frank M.
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.12327/2033
Acesso em linha:http://hdl.handle.net/20.500.12327/2033
https://doi.org/10.1038/s41467-022-34312-7
Access Level:acceso abierto
Palavra-chave:619
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repository_id_str
spelling Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistanceMunk, PatrickBrinch, ChristianMøller, Frederik DuusPetersen, Thomas N.Hendriksen, Rene S.Seyfarth, Anne MetteKjeldgaard, Jette S.Svendsen, Christina Aabyvan Bunnik, BramBerglund, FannyGlobal Sewage Surveillance ConsortiumCerdà-Cuéllar, MartaLarsson, D. G. JoakimKoopmans, MarionWoolhouse, MarkAarestrup, Frank M.619Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.info:eu-repo/semantics/publishedVersionNature ResearchProducció AnimalSanitat Animal2022info:eu-repo/semantics/article16http://hdl.handle.net/20.500.12327/2033https://doi.org/10.1038/s41467-022-34312-7reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésNature CommunicationsEC/H2020/874735/EU/Versatile Emerging infectious disease Observatory/VEOAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:20.500.12327/20332026-05-29T05:05:01Z
dc.title.none.fl_str_mv Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
title Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
spellingShingle Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
Munk, Patrick
619
title_short Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
title_full Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
title_fullStr Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
title_full_unstemmed Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
title_sort Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance
dc.creator.none.fl_str_mv Munk, Patrick
Brinch, Christian
Møller, Frederik Duus
Petersen, Thomas N.
Hendriksen, Rene S.
Seyfarth, Anne Mette
Kjeldgaard, Jette S.
Svendsen, Christina Aaby
van Bunnik, Bram
Berglund, Fanny
Global Sewage Surveillance Consortium
Cerdà-Cuéllar, Marta
Larsson, D. G. Joakim
Koopmans, Marion
Woolhouse, Mark
Aarestrup, Frank M.
author Munk, Patrick
author_facet Munk, Patrick
Brinch, Christian
Møller, Frederik Duus
Petersen, Thomas N.
Hendriksen, Rene S.
Seyfarth, Anne Mette
Kjeldgaard, Jette S.
Svendsen, Christina Aaby
van Bunnik, Bram
Berglund, Fanny
Global Sewage Surveillance Consortium
Cerdà-Cuéllar, Marta
Larsson, D. G. Joakim
Koopmans, Marion
Woolhouse, Mark
Aarestrup, Frank M.
author_role author
author2 Brinch, Christian
Møller, Frederik Duus
Petersen, Thomas N.
Hendriksen, Rene S.
Seyfarth, Anne Mette
Kjeldgaard, Jette S.
Svendsen, Christina Aaby
van Bunnik, Bram
Berglund, Fanny
Global Sewage Surveillance Consortium
Cerdà-Cuéllar, Marta
Larsson, D. G. Joakim
Koopmans, Marion
Woolhouse, Mark
Aarestrup, Frank M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Producció Animal
Sanitat Animal
dc.subject.none.fl_str_mv 619
topic 619
description Antimicrobial resistance (AMR) is a major threat to global health. Understanding the emergence, evolution, and transmission of individual antibiotic resistance genes (ARGs) is essential to develop sustainable strategies combatting this threat. Here, we use metagenomic sequencing to analyse ARGs in 757 sewage samples from 243 cities in 101 countries, collected from 2016 to 2019. We find regional patterns in resistomes, and these differ between subsets corresponding to drug classes and are partly driven by taxonomic variation. The genetic environments of 49 common ARGs are highly diverse, with most common ARGs carried by multiple distinct genomic contexts globally and sometimes on plasmids. Analysis of flanking sequence revealed ARG-specific patterns of dispersal limitation and global transmission. Our data furthermore suggest certain geographies are more prone to transmission events and should receive additional attention.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12327/2033
https://doi.org/10.1038/s41467-022-34312-7
url http://hdl.handle.net/20.500.12327/2033
https://doi.org/10.1038/s41467-022-34312-7
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Nature Communications
EC/H2020/874735/EU/Versatile Emerging infectious disease Observatory/VEO
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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