The role of lysyl oxidase enzymes in cardiac function and remodeling

Lysyl oxidase (LOX) proteins comprise a family of five copper-dependent enzymes (LOX and four LOX-like isoenzymes (LOXL1–4)) critical for extracellular matrix (ECM) homeostasis and remodeling. The primary role of LOX enzymes is to oxidize lysyl and hydroxylysyl residues from collagen and elastin cha...

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Detalhes bibliográficos
Autores: Rodríguez-Sinovas, Cristina, Martínez-González, José
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/197153
Acesso em linha:http://hdl.handle.net/10261/197153
Access Level:Acceso aberto
Palavra-chave:Lysyl oxidases
Cardiac function
Myocardial hypertrophy
Extracellular matrix remodeling
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spelling The role of lysyl oxidase enzymes in cardiac function and remodelingRodríguez-Sinovas, CristinaMartínez-González, JoséLysyl oxidasesCardiac functionMyocardial hypertrophyExtracellular matrix remodelingLysyl oxidase (LOX) proteins comprise a family of five copper-dependent enzymes (LOX and four LOX-like isoenzymes (LOXL1–4)) critical for extracellular matrix (ECM) homeostasis and remodeling. The primary role of LOX enzymes is to oxidize lysyl and hydroxylysyl residues from collagen and elastin chains into highly reactive aldehydes, which spontaneously react with surrounding amino groups and other aldehydes to form inter- and intra-catenary covalent cross-linkages. Therefore, they are essential for the synthesis of a mature ECM and assure matrix integrity. ECM modulates cellular phenotype and function, and strikingly influences the mechanical properties of tissues. This explains the critical role of these enzymes in tissue homeostasis, and in tissue repair and remodeling. Cardiac ECM is mainly composed of fibrillar collagens which form a complex network that provides structural and biochemical support to cardiac cells and regulates cell signaling pathways. It is now becoming apparent that cardiac performance is affected by the structure and composition of the ECM and that any disturbance of the ECM contributes to cardiac disease progression. This review article compiles the major findings on the contribution of the LOX family to the development and progression of myocardial disorders.The authors gratefully appreciate the support provided by the Spanish Ministerio de Ciencia, Innovación y Universidades (MICIU), Instituto de Salud Carlos III (ISCIII) [grants RTI2018-094727-B-100, PI18/0919], Fundació La Marató de TV3 (20152330) and Agencia de Gestio d’Ajuts Universitaris i de Recerca (AGAUR; program of Support to Research Groups, Ref. 2017-SGR-00333). Our studies were also co-founded by Fondo Europeo de Desarrollo Regional (FEDER), a way to make Europe.Peer reviewedMultidisciplinary Digital Publishing InstituteMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Instituto de Salud Carlos IIIFundació La Marató de TV3Generalitat de CatalunyaEuropean CommissionRodríguez, Cristina [0000-0002-6472-5647]Martínez-González, José [0000-0002-3894-7166]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2019201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/197153reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094727-B-100RTI2018-094727-B-100/AEI/10.13039/501100011033https://doi.org/10.3390/cells8121483Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1971532026-05-22T06:33:51Z
dc.title.none.fl_str_mv The role of lysyl oxidase enzymes in cardiac function and remodeling
title The role of lysyl oxidase enzymes in cardiac function and remodeling
spellingShingle The role of lysyl oxidase enzymes in cardiac function and remodeling
Rodríguez-Sinovas, Cristina
Lysyl oxidases
Cardiac function
Myocardial hypertrophy
Extracellular matrix remodeling
title_short The role of lysyl oxidase enzymes in cardiac function and remodeling
title_full The role of lysyl oxidase enzymes in cardiac function and remodeling
title_fullStr The role of lysyl oxidase enzymes in cardiac function and remodeling
title_full_unstemmed The role of lysyl oxidase enzymes in cardiac function and remodeling
title_sort The role of lysyl oxidase enzymes in cardiac function and remodeling
dc.creator.none.fl_str_mv Rodríguez-Sinovas, Cristina
Martínez-González, José
author Rodríguez-Sinovas, Cristina
author_facet Rodríguez-Sinovas, Cristina
Martínez-González, José
author_role author
author2 Martínez-González, José
author2_role author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Instituto de Salud Carlos III
Fundació La Marató de TV3
Generalitat de Catalunya
European Commission
Rodríguez, Cristina [0000-0002-6472-5647]
Martínez-González, José [0000-0002-3894-7166]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Lysyl oxidases
Cardiac function
Myocardial hypertrophy
Extracellular matrix remodeling
topic Lysyl oxidases
Cardiac function
Myocardial hypertrophy
Extracellular matrix remodeling
description Lysyl oxidase (LOX) proteins comprise a family of five copper-dependent enzymes (LOX and four LOX-like isoenzymes (LOXL1–4)) critical for extracellular matrix (ECM) homeostasis and remodeling. The primary role of LOX enzymes is to oxidize lysyl and hydroxylysyl residues from collagen and elastin chains into highly reactive aldehydes, which spontaneously react with surrounding amino groups and other aldehydes to form inter- and intra-catenary covalent cross-linkages. Therefore, they are essential for the synthesis of a mature ECM and assure matrix integrity. ECM modulates cellular phenotype and function, and strikingly influences the mechanical properties of tissues. This explains the critical role of these enzymes in tissue homeostasis, and in tissue repair and remodeling. Cardiac ECM is mainly composed of fibrillar collagens which form a complex network that provides structural and biochemical support to cardiac cells and regulates cell signaling pathways. It is now becoming apparent that cardiac performance is affected by the structure and composition of the ECM and that any disturbance of the ECM contributes to cardiac disease progression. This review article compiles the major findings on the contribution of the LOX family to the development and progression of myocardial disorders.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/197153
url http://hdl.handle.net/10261/197153
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI2018-094727-B-100
RTI2018-094727-B-100/AEI/10.13039/501100011033
https://doi.org/10.3390/cells8121483
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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