Energy transfer from magnetic iron oxide nanoparticles: Implications for magnetic hyperthermia

Magnetic iron oxide nanoparticles (IONPs) have gained momentum in the field of biomedical applications. They can be remotely heated via alternating magnetic fields, and such heat can be transferred from the IONPs to the local environment. However, the microscopic mechanism of heat transfer is still...

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Autores: Tabacchi, Gloria, Armenia, Ilaria, Bernardini, Giovanni, Masciocchi, Norberto, Guagliardi, Antonietta, Fois, Ettore
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2023
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositório:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/343517
Acesso em linha:http://hdl.handle.net/10261/343517
Access Level:Acceso aberto
Palavra-chave:Magnetic iron oxide
Magnetic nanoparticle hyperthermia
Density functional calculations
X-ray diffraction
Nanoparticles
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spelling Energy transfer from magnetic iron oxide nanoparticles: Implications for magnetic hyperthermiaTabacchi, GloriaArmenia, IlariaBernardini, GiovanniMasciocchi, NorbertoGuagliardi, AntoniettaFois, EttoreMagnetic iron oxideMagnetic nanoparticle hyperthermiaDensity functional calculationsX-ray diffractionNanoparticlesMagnetic iron oxide nanoparticles (IONPs) have gained momentum in the field of biomedical applications. They can be remotely heated via alternating magnetic fields, and such heat can be transferred from the IONPs to the local environment. However, the microscopic mechanism of heat transfer is still debated. By X-ray total scattering experiments and first-principles simulations, we show how such heat transfer can occur. After establishing structural and microstructural properties of the maghemite phase of the IONPs, we built a maghemite model functionalized with aminoalkoxysilane, a molecule used to anchor (bio)molecules to oxide surfaces. By a linear response theory approach, we reveal that a resonance mechanism is responsible for the heat transfer from the IONPs to the surroundings. Heat transfer occurs not only via covalent linkages with the IONP but also through the solvent hydrogen-bond network. This result may pave the way to exploit the directional control of the heat flow from the IONPs to the anchored molecules─i.e., antibiotics, therapeutics, and enzymes─for their activation or release in a broader range of medical and industrial applications.This work was supported by FAR (University of Insubria) to N.M., G.T., and E.F. and by HOTZYMES project (Grant 829162) under EU’s Horizon 2020 Programme (H2020-FETOPEN) to I.A. and G.B.Peer reviewedAmerican Chemical SocietyUniversità degli studi dell'InsubriaEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/343517reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/829162Tabacchi, Gloria; Armenia, Ilaria; Bernardini, Giovanni; Masciocchi, Norberto; Guagliardi, Antonietta; Fois, Ettore; 2023; Supporting Information for: Energy transfer from magnetic iron oxide nanoparticles: Implications for magnetic hyperthermia [Dataset]; American Chemical Society; https://doi.org/10.1021/acsanm.3c01643https://doi.org/10.1021/acsanm.3c01643Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3435172026-05-22T06:33:51Z
dc.title.none.fl_str_mv Energy transfer from magnetic iron oxide nanoparticles: Implications for magnetic hyperthermia
title Energy transfer from magnetic iron oxide nanoparticles: Implications for magnetic hyperthermia
spellingShingle Energy transfer from magnetic iron oxide nanoparticles: Implications for magnetic hyperthermia
Tabacchi, Gloria
Magnetic iron oxide
Magnetic nanoparticle hyperthermia
Density functional calculations
X-ray diffraction
Nanoparticles
title_short Energy transfer from magnetic iron oxide nanoparticles: Implications for magnetic hyperthermia
title_full Energy transfer from magnetic iron oxide nanoparticles: Implications for magnetic hyperthermia
title_fullStr Energy transfer from magnetic iron oxide nanoparticles: Implications for magnetic hyperthermia
title_full_unstemmed Energy transfer from magnetic iron oxide nanoparticles: Implications for magnetic hyperthermia
title_sort Energy transfer from magnetic iron oxide nanoparticles: Implications for magnetic hyperthermia
dc.creator.none.fl_str_mv Tabacchi, Gloria
Armenia, Ilaria
Bernardini, Giovanni
Masciocchi, Norberto
Guagliardi, Antonietta
Fois, Ettore
author Tabacchi, Gloria
author_facet Tabacchi, Gloria
Armenia, Ilaria
Bernardini, Giovanni
Masciocchi, Norberto
Guagliardi, Antonietta
Fois, Ettore
author_role author
author2 Armenia, Ilaria
Bernardini, Giovanni
Masciocchi, Norberto
Guagliardi, Antonietta
Fois, Ettore
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Università degli studi dell'Insubria
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Magnetic iron oxide
Magnetic nanoparticle hyperthermia
Density functional calculations
X-ray diffraction
Nanoparticles
topic Magnetic iron oxide
Magnetic nanoparticle hyperthermia
Density functional calculations
X-ray diffraction
Nanoparticles
description Magnetic iron oxide nanoparticles (IONPs) have gained momentum in the field of biomedical applications. They can be remotely heated via alternating magnetic fields, and such heat can be transferred from the IONPs to the local environment. However, the microscopic mechanism of heat transfer is still debated. By X-ray total scattering experiments and first-principles simulations, we show how such heat transfer can occur. After establishing structural and microstructural properties of the maghemite phase of the IONPs, we built a maghemite model functionalized with aminoalkoxysilane, a molecule used to anchor (bio)molecules to oxide surfaces. By a linear response theory approach, we reveal that a resonance mechanism is responsible for the heat transfer from the IONPs to the surroundings. Heat transfer occurs not only via covalent linkages with the IONP but also through the solvent hydrogen-bond network. This result may pave the way to exploit the directional control of the heat flow from the IONPs to the anchored molecules─i.e., antibiotics, therapeutics, and enzymes─for their activation or release in a broader range of medical and industrial applications.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/343517
url http://hdl.handle.net/10261/343517
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/829162
Tabacchi, Gloria; Armenia, Ilaria; Bernardini, Giovanni; Masciocchi, Norberto; Guagliardi, Antonietta; Fois, Ettore; 2023; Supporting Information for: Energy transfer from magnetic iron oxide nanoparticles: Implications for magnetic hyperthermia [Dataset]; American Chemical Society; https://doi.org/10.1021/acsanm.3c01643
https://doi.org/10.1021/acsanm.3c01643
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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