Role of C-JUN terminal kinases (JNK1/2) in the development of cancer of the biliary tract

Cholangiocarcinoma (CCA) is an aggressive malignant bile duct cancer, and the second most common primary liver tumor In Europe, around 13,000 new CCA cases were diagnosed per year. However, the pathogenesis of CCA remains elusive and lack of diagnostic as well as treatment tools impede a better outc...

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Detalles Bibliográficos
Autor: Chen, Chaobo
Tipo de recurso: tesis doctoral
Fecha de publicación:2021
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/5483
Acceso en línea:https://hdl.handle.net/20.500.14352/5483
Access Level:acceso abierto
Palabra clave:616.361-006.04(043.2)
Cancer of the biliary tract
C-JUN terminal kinases (JNK1/2)
Cáncer de vías biliares
C-JUN cinasas N-terminales (JNK)
Gastroenterología y hepatología
Oncología
3205.03 Gastroenterología
3201.01 Oncología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/5483
network_acronym_str ES
network_name_str España
repository_id_str
spelling Role of C-JUN terminal kinases (JNK1/2) in the development of cancer of the biliary tractPapel de las C-JUN cinasas N-terminales (JNK) en el desarrollo de cáncer de vías biliaresChen, Chaobo616.361-006.04(043.2)Cancer of the biliary tractC-JUN terminal kinases (JNK1/2)Cáncer de vías biliaresC-JUN cinasas N-terminales (JNK)Gastroenterología y hepatologíaOncología3205.03 Gastroenterología3201.01 OncologíaCholangiocarcinoma (CCA) is an aggressive malignant bile duct cancer, and the second most common primary liver tumor In Europe, around 13,000 new CCA cases were diagnosed per year. However, the pathogenesis of CCA remains elusive and lack of diagnostic as well as treatment tools impede a better outcome for patients. In the present study, we use a new animal model of CCA, to understand the molecular mechanism. In the present work, we hypothesize that the synergistic dysfunction of Jnk1 and Jnk2 in hepatocytes drives the development of cholangiocarcinogenesis. Mice with specific deletion of Jnk1/2 in hepatocytes (JnkΔhepa) and floxed (Jnkf/f) control mice were sacrificed at different time points during liver disease progression. Likewise, different toxicity treatments (i.e., TAA, DEN/TAA and DEN/CCl4) and experimental models were used...Universidad Complutense de MadridCubero Palero, JavierNevzorova, Yulia A.Universidad Complutense de Madrid20212021-07-1420212021-07-14doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttps://hdl.handle.net/20.500.14352/5483reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/54832026-06-02T12:44:21Z
dc.title.none.fl_str_mv Role of C-JUN terminal kinases (JNK1/2) in the development of cancer of the biliary tract
Papel de las C-JUN cinasas N-terminales (JNK) en el desarrollo de cáncer de vías biliares
title Role of C-JUN terminal kinases (JNK1/2) in the development of cancer of the biliary tract
spellingShingle Role of C-JUN terminal kinases (JNK1/2) in the development of cancer of the biliary tract
Chen, Chaobo
616.361-006.04(043.2)
Cancer of the biliary tract
C-JUN terminal kinases (JNK1/2)
Cáncer de vías biliares
C-JUN cinasas N-terminales (JNK)
Gastroenterología y hepatología
Oncología
3205.03 Gastroenterología
3201.01 Oncología
title_short Role of C-JUN terminal kinases (JNK1/2) in the development of cancer of the biliary tract
title_full Role of C-JUN terminal kinases (JNK1/2) in the development of cancer of the biliary tract
title_fullStr Role of C-JUN terminal kinases (JNK1/2) in the development of cancer of the biliary tract
title_full_unstemmed Role of C-JUN terminal kinases (JNK1/2) in the development of cancer of the biliary tract
title_sort Role of C-JUN terminal kinases (JNK1/2) in the development of cancer of the biliary tract
dc.creator.none.fl_str_mv Chen, Chaobo
author Chen, Chaobo
author_facet Chen, Chaobo
author_role author
dc.contributor.none.fl_str_mv Cubero Palero, Javier
Nevzorova, Yulia A.
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616.361-006.04(043.2)
Cancer of the biliary tract
C-JUN terminal kinases (JNK1/2)
Cáncer de vías biliares
C-JUN cinasas N-terminales (JNK)
Gastroenterología y hepatología
Oncología
3205.03 Gastroenterología
3201.01 Oncología
topic 616.361-006.04(043.2)
Cancer of the biliary tract
C-JUN terminal kinases (JNK1/2)
Cáncer de vías biliares
C-JUN cinasas N-terminales (JNK)
Gastroenterología y hepatología
Oncología
3205.03 Gastroenterología
3201.01 Oncología
description Cholangiocarcinoma (CCA) is an aggressive malignant bile duct cancer, and the second most common primary liver tumor In Europe, around 13,000 new CCA cases were diagnosed per year. However, the pathogenesis of CCA remains elusive and lack of diagnostic as well as treatment tools impede a better outcome for patients. In the present study, we use a new animal model of CCA, to understand the molecular mechanism. In the present work, we hypothesize that the synergistic dysfunction of Jnk1 and Jnk2 in hepatocytes drives the development of cholangiocarcinogenesis. Mice with specific deletion of Jnk1/2 in hepatocytes (JnkΔhepa) and floxed (Jnkf/f) control mice were sacrificed at different time points during liver disease progression. Likewise, different toxicity treatments (i.e., TAA, DEN/TAA and DEN/CCl4) and experimental models were used...
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-07-14
2021
2021-07-14
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/5483
url https://hdl.handle.net/20.500.14352/5483
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Complutense de Madrid
publisher.none.fl_str_mv Universidad Complutense de Madrid
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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