Prussian Blue tablets for cesium decorporation: pH-dependent performance under normogastric and hypochlorhydric conditions in an in vitro gastrointestinal model

28 p.

Detalhes bibliográficos
Autores: Martínez Alonso, Borja, Torrado Durán, Guillermo|||0000-0002-8865-2083, Pardo Laurel, Hugo, Guarnizo Herrero, Víctor|||0000-0001-9323-3388, Peña Fernández, María De Los Ángeles|||0000-0002-0908-8286
Formato: artículo
Fecha de publicación:2025
País:España
Recursos:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/68322
Acesso em linha:http://hdl.handle.net/10017/68322
https://dx.doi.org/10.3390/ph18111702
Access Level:acceso abierto
Palavra-chave:Prussian blue
Antidote
Cesium decorporation
In vitro gastrointestinal model
Tablets
Target
Farmacia
Biología y Biomedicina/Biología
Pharmacy
Biology
id ES_4a45ac21f8a67911cb77f7ceda10716e
oai_identifier_str oai:ebuah.uah.es:10017/68322
network_acronym_str ES
network_name_str España
repository_id_str
spelling Prussian Blue tablets for cesium decorporation: pH-dependent performance under normogastric and hypochlorhydric conditions in an in vitro gastrointestinal modelMartínez Alonso, BorjaTorrado Durán, Guillermo|||0000-0002-8865-2083Pardo Laurel, HugoGuarnizo Herrero, Víctor|||0000-0001-9323-3388Peña Fernández, María De Los Ángeles|||0000-0002-0908-8286Prussian blueAntidoteCesium decorporationIn vitro gastrointestinal modelTabletsTargetFarmaciaBiología y Biomedicina/BiologíaPharmacyBiology28 p.Background/Objectives: Prussian blue (PB) is the agent of choice for internal cesium (Cs) decorporation, yet its performance is critically dependent on gastrointestinal (GI) pH and formulation attributes. Hypochlorhydria, common in patients treated with proton pump inhibitors, may alter the stagewise distribution of Cs binding during GI transit. This study aimed to compare the performance of different PB formulations in sequential in vitro models simulating normogastria and hypochlorhydria: normogastric regimen (NG) and hypochlorhydric regimen (HC). Methods: A static, enzyme-free sequential model was applied using compendial simulated fluids (SGFs pH 1.2 or acetate pH 4.0, SIF pH 6.8, and phosphate buffer pH 7.2). The formulations tested included PB active pharmaceutical ingredient (API) (bulk), compression blend, PB tablets 500 mg (PB tablets), and Radiogardase®. For each stage, cesium bound (qs, mg/g PB), fractional contributions (fs), and total capture (qtotal) were quantified. Additional analyses included sensitivity to initial Cs concentration (C0) and desorption in mineralized water. Results: Overall performance was primarily determined by formulation (p < 0.0001), with a significant formulation × regimen interaction. The compression blend and PB tablets exhibited the highest decorporation capacity, PB-API showed intermediate performance, and Radiogardase® was clearly lower. Under HC, capture was concentrated in the gastric stage (44-47%), whereas in NG, it shifted toward intestinal stages. Desorption in the mineralized water was statistically significant but negligible compared with total capture, supporting the stability of cesium sequestration. Conclusions: Formulation and gastric acidity regimens not only determine the total cesium capture but also redistribute it across the GI tract. PB tablets represent an effective and accessible alternative to Radiogardase®, maintaining robust decorporation capacity under clinically relevant pH conditions.Subdirección General de Planificación, Tecnología e Innovación (SDG PLATIN) del Ministerio de Defensa, Gobierno de España20252025-11-10journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/68322https://dx.doi.org/10.3390/ph1811170241304948reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengMINISDEF Not available SYP41804 Contramedidas médicasopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/683222026-06-18T11:13:07Z
dc.title.none.fl_str_mv Prussian Blue tablets for cesium decorporation: pH-dependent performance under normogastric and hypochlorhydric conditions in an in vitro gastrointestinal model
title Prussian Blue tablets for cesium decorporation: pH-dependent performance under normogastric and hypochlorhydric conditions in an in vitro gastrointestinal model
spellingShingle Prussian Blue tablets for cesium decorporation: pH-dependent performance under normogastric and hypochlorhydric conditions in an in vitro gastrointestinal model
Martínez Alonso, Borja
Prussian blue
Antidote
Cesium decorporation
In vitro gastrointestinal model
Tablets
Target
Farmacia
Biología y Biomedicina/Biología
Pharmacy
Biology
title_short Prussian Blue tablets for cesium decorporation: pH-dependent performance under normogastric and hypochlorhydric conditions in an in vitro gastrointestinal model
title_full Prussian Blue tablets for cesium decorporation: pH-dependent performance under normogastric and hypochlorhydric conditions in an in vitro gastrointestinal model
title_fullStr Prussian Blue tablets for cesium decorporation: pH-dependent performance under normogastric and hypochlorhydric conditions in an in vitro gastrointestinal model
title_full_unstemmed Prussian Blue tablets for cesium decorporation: pH-dependent performance under normogastric and hypochlorhydric conditions in an in vitro gastrointestinal model
title_sort Prussian Blue tablets for cesium decorporation: pH-dependent performance under normogastric and hypochlorhydric conditions in an in vitro gastrointestinal model
dc.creator.none.fl_str_mv Martínez Alonso, Borja
Torrado Durán, Guillermo|||0000-0002-8865-2083
Pardo Laurel, Hugo
Guarnizo Herrero, Víctor|||0000-0001-9323-3388
Peña Fernández, María De Los Ángeles|||0000-0002-0908-8286
author Martínez Alonso, Borja
author_facet Martínez Alonso, Borja
Torrado Durán, Guillermo|||0000-0002-8865-2083
Pardo Laurel, Hugo
Guarnizo Herrero, Víctor|||0000-0001-9323-3388
Peña Fernández, María De Los Ángeles|||0000-0002-0908-8286
author_role author
author2 Torrado Durán, Guillermo|||0000-0002-8865-2083
Pardo Laurel, Hugo
Guarnizo Herrero, Víctor|||0000-0001-9323-3388
Peña Fernández, María De Los Ángeles|||0000-0002-0908-8286
author2_role author
author
author
author
dc.subject.none.fl_str_mv Prussian blue
Antidote
Cesium decorporation
In vitro gastrointestinal model
Tablets
Target
Farmacia
Biología y Biomedicina/Biología
Pharmacy
Biology
topic Prussian blue
Antidote
Cesium decorporation
In vitro gastrointestinal model
Tablets
Target
Farmacia
Biología y Biomedicina/Biología
Pharmacy
Biology
description 28 p.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-11-10
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/68322
https://dx.doi.org/10.3390/ph18111702
41304948
url http://hdl.handle.net/10017/68322
https://dx.doi.org/10.3390/ph18111702
identifier_str_mv 41304948
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv MINISDEF Not available SYP41804 Contramedidas médicas
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869407475422199808
score 15.812429

Registos relacionados