ccz-1 mediates the digestion of apoptotic corpses in C. elegans

7 páginas, 4 figuras.-- et al.

Detalles Bibliográficos
Autores: Nieto-Jiménez, Cristina, Moreno, Sergio, Cabello, Juan
Tipo de recurso: artículo
Fecha de publicación:2010
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/45948
Acceso en línea:http://hdl.handle.net/10261/45948
Access Level:acceso abierto
Palabra clave:Apoptosis
C. elegans
Phagosome Maturation
ccz-1
Digestion Pathway
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spelling ccz-1 mediates the digestion of apoptotic corpses in C. elegansNieto-Jiménez, CristinaMoreno, SergioCabello, JuanApoptosisC. elegansPhagosome Maturationccz-1Digestion Pathway7 páginas, 4 figuras.-- et al.During development, the processes of cell division, differentiation and apoptosis must be precisely coordinated in order to maintain tissue homeostasis. The nematode C. elegans is a powerful model system in which to study cell death and its control. C. elegans apoptotic cells condense and form refractile corpses under differential interference contrast (DIC) microscopy. Activation of the GTPase CED-10 (Rac) in a neighbouring cell mediates the recognition and engulfment of the cell corpse. After inclusion of the engulfed corpse in a phagosome, different proteins are sequentially recruited onto this organelle to promote its acidification and fusion with lysosomes, leading to the enzymatic degradation of the cell corpse. We show that CCZ-1, a protein conserved from yeasts to humans, mediates the digestion of these apoptotic corpses. CCZ-1 seems to act in lysosome biogenesis and phagosome maturation by recruiting the GTPase RAB-7 over the phagosome.This work was supported by the Junta de Castilla y León (grants CSI03A08 and Grupo de Excelencia GR265), the Spanish Ministry of Science and Innovation (grants BFU2008-01808 and Consolider CSD2007-00015), the ‘Fundación Rioja Salud’, the ‘Fundación Memoria D. Samuel Solorzano Barruso’, the Swiss National Science Foundation and the Ernst Hadorn Foundation. C.N. and J.C. were each supported by the I3P programme of the Spanish National Research Council (CSIC).Peer reviewedCompany of Biologists201220122010info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/45948reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1242/jcs.062331info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/459482026-05-22T06:33:51Z
dc.title.none.fl_str_mv ccz-1 mediates the digestion of apoptotic corpses in C. elegans
title ccz-1 mediates the digestion of apoptotic corpses in C. elegans
spellingShingle ccz-1 mediates the digestion of apoptotic corpses in C. elegans
Nieto-Jiménez, Cristina
Apoptosis
C. elegans
Phagosome Maturation
ccz-1
Digestion Pathway
title_short ccz-1 mediates the digestion of apoptotic corpses in C. elegans
title_full ccz-1 mediates the digestion of apoptotic corpses in C. elegans
title_fullStr ccz-1 mediates the digestion of apoptotic corpses in C. elegans
title_full_unstemmed ccz-1 mediates the digestion of apoptotic corpses in C. elegans
title_sort ccz-1 mediates the digestion of apoptotic corpses in C. elegans
dc.creator.none.fl_str_mv Nieto-Jiménez, Cristina
Moreno, Sergio
Cabello, Juan
author Nieto-Jiménez, Cristina
author_facet Nieto-Jiménez, Cristina
Moreno, Sergio
Cabello, Juan
author_role author
author2 Moreno, Sergio
Cabello, Juan
author2_role author
author
dc.subject.none.fl_str_mv Apoptosis
C. elegans
Phagosome Maturation
ccz-1
Digestion Pathway
topic Apoptosis
C. elegans
Phagosome Maturation
ccz-1
Digestion Pathway
description 7 páginas, 4 figuras.-- et al.
publishDate 2010
dc.date.none.fl_str_mv 2010
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/45948
url http://hdl.handle.net/10261/45948
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1242/jcs.062331
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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