White Matter/Gray Matter Contrast Changes in Chronic and Diffuse Traumatic brain Injury

Signal-intensity contrast of T1-weighted magnetic resonance imaging scans has been associated with tissue integrity and reported as a sign of neurodegenerative changes in diseases such as Alzheimer's disease. After severe traumatic brain injury (TBI), progressive structural changes occur in whi...

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Autores: Palacios, Eva M., Sala Llonch, Roser, Junqué i Plaja, Carme, 1955-, Roig-Rovira, Teresa, Tormos, José María, Bargalló Alabart, Núria, Vendrell i Gómez, Pere
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/163166
Acesso em linha:https://hdl.handle.net/2445/163166
Access Level:acceso abierto
Palavra-chave:Traumatismes cranials
Trastorns de la cognició
Imatges per ressonància magnètica
Skull injuries
Cognition disorders
Magnetic resonance imaging
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spelling White Matter/Gray Matter Contrast Changes in Chronic and Diffuse Traumatic brain InjuryPalacios, Eva M.Sala Llonch, RoserJunqué i Plaja, Carme, 1955-Roig-Rovira, TeresaTormos, José MaríaBargalló Alabart, NúriaVendrell i Gómez, PereTraumatismes cranialsTrastorns de la cognicióImatges per ressonància magnèticaSkull injuriesCognition disordersMagnetic resonance imagingSignal-intensity contrast of T1-weighted magnetic resonance imaging scans has been associated with tissue integrity and reported as a sign of neurodegenerative changes in diseases such as Alzheimer's disease. After severe traumatic brain injury (TBI), progressive structural changes occur in white (WM) and gray matter (GM). In the current study, we assessed the signal-intensity contrast of GM and WM in patients with diffuse TBI in the chronic stage to (1) characterize the regional pattern of WM/GM changes in intensity contrast associated with traumatic axonal injury, (2) evaluate possible associations between this measure and diffusion tensor image (DTI)/fractional anisotropy (FA) for detecting WM damage, and (3) investigate the correlates of both measures with cognitive outcomes. Structural T1 scans were processed with FreeSurfer software to identify the boundary and calculate the WM/GM contrast maps. DTIs were processed with the FMRIB software library to obtain FA maps. The WM/GM contrast in TBI patients showed a pattern of reduction in almost all of the brain, except the visual and motor primary regions. Global FA values obtained from DTI correlated with the intensity contrast of all associative cerebral regions. WM/GM contrast correlated with memory functions, whereas FA global values correlated with tests measuring memory and mental processing speed. In conclusion, tissue-contrast intensity is a very sensitive measure for detecting structural brain damage in chronic, severe and diffuse TBI, but is less sensitive than FA for reflecting neuropsychological sequelae, such as impaired mental processing speed.Mary Ann Liebert2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/163166Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1089/neu.2012.2836Journal of Neurotrauma, 2013, vol. 30, num. 23, p. 1991-1994https://doi.org/10.1089/neu.2012.2836(c) Mary Ann Liebert, 2013info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1631662026-05-27T06:46:51Z
dc.title.none.fl_str_mv White Matter/Gray Matter Contrast Changes in Chronic and Diffuse Traumatic brain Injury
title White Matter/Gray Matter Contrast Changes in Chronic and Diffuse Traumatic brain Injury
spellingShingle White Matter/Gray Matter Contrast Changes in Chronic and Diffuse Traumatic brain Injury
Palacios, Eva M.
Traumatismes cranials
Trastorns de la cognició
Imatges per ressonància magnètica
Skull injuries
Cognition disorders
Magnetic resonance imaging
title_short White Matter/Gray Matter Contrast Changes in Chronic and Diffuse Traumatic brain Injury
title_full White Matter/Gray Matter Contrast Changes in Chronic and Diffuse Traumatic brain Injury
title_fullStr White Matter/Gray Matter Contrast Changes in Chronic and Diffuse Traumatic brain Injury
title_full_unstemmed White Matter/Gray Matter Contrast Changes in Chronic and Diffuse Traumatic brain Injury
title_sort White Matter/Gray Matter Contrast Changes in Chronic and Diffuse Traumatic brain Injury
dc.creator.none.fl_str_mv Palacios, Eva M.
Sala Llonch, Roser
Junqué i Plaja, Carme, 1955-
Roig-Rovira, Teresa
Tormos, José María
Bargalló Alabart, Núria
Vendrell i Gómez, Pere
author Palacios, Eva M.
author_facet Palacios, Eva M.
Sala Llonch, Roser
Junqué i Plaja, Carme, 1955-
Roig-Rovira, Teresa
Tormos, José María
Bargalló Alabart, Núria
Vendrell i Gómez, Pere
author_role author
author2 Sala Llonch, Roser
Junqué i Plaja, Carme, 1955-
Roig-Rovira, Teresa
Tormos, José María
Bargalló Alabart, Núria
Vendrell i Gómez, Pere
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Traumatismes cranials
Trastorns de la cognició
Imatges per ressonància magnètica
Skull injuries
Cognition disorders
Magnetic resonance imaging
topic Traumatismes cranials
Trastorns de la cognició
Imatges per ressonància magnètica
Skull injuries
Cognition disorders
Magnetic resonance imaging
description Signal-intensity contrast of T1-weighted magnetic resonance imaging scans has been associated with tissue integrity and reported as a sign of neurodegenerative changes in diseases such as Alzheimer's disease. After severe traumatic brain injury (TBI), progressive structural changes occur in white (WM) and gray matter (GM). In the current study, we assessed the signal-intensity contrast of GM and WM in patients with diffuse TBI in the chronic stage to (1) characterize the regional pattern of WM/GM changes in intensity contrast associated with traumatic axonal injury, (2) evaluate possible associations between this measure and diffusion tensor image (DTI)/fractional anisotropy (FA) for detecting WM damage, and (3) investigate the correlates of both measures with cognitive outcomes. Structural T1 scans were processed with FreeSurfer software to identify the boundary and calculate the WM/GM contrast maps. DTIs were processed with the FMRIB software library to obtain FA maps. The WM/GM contrast in TBI patients showed a pattern of reduction in almost all of the brain, except the visual and motor primary regions. Global FA values obtained from DTI correlated with the intensity contrast of all associative cerebral regions. WM/GM contrast correlated with memory functions, whereas FA global values correlated with tests measuring memory and mental processing speed. In conclusion, tissue-contrast intensity is a very sensitive measure for detecting structural brain damage in chronic, severe and diffuse TBI, but is less sensitive than FA for reflecting neuropsychological sequelae, such as impaired mental processing speed.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/163166
url https://hdl.handle.net/2445/163166
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1089/neu.2012.2836
Journal of Neurotrauma, 2013, vol. 30, num. 23, p. 1991-1994
https://doi.org/10.1089/neu.2012.2836
dc.rights.none.fl_str_mv (c) Mary Ann Liebert, 2013
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Mary Ann Liebert, 2013
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301629

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