Mechanisms of Modulation of Mitochondrial Architecture

Mitochondrial network architecture plays a critical role in cellular physiology. Indeed, alterations in the shape of mitochondria upon exposure to cellular stress can cause the dysfunction of these organelles. In this scenario, mitochondrial dynamics proteins and the phospholipid composition of the...

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Autores: Muñoz, Juan Pablo|||0000-0003-0912-4168, Basei, Fernanda Luisa|||0000-0001-6232-7170, Rojas, Maria Laura|||0000-0001-9849-7163, Galvis, David, Zorzano Olarte, Antonio|||0000-0002-1638-0306
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:303850
Acceso en línea:https://ddd.uab.cat/record/303850
https://dx.doi.org/urn:doi:10.3390/biom13081225
Access Level:acceso abierto
Palabra clave:Lipids
Membrane contact sites (MCSs)
Metabolic disease
Metabolism
Mitochondria
Mitochondrial dynamics
Pharmacology
Post-translational modification
Tethers
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spelling Mechanisms of Modulation of Mitochondrial ArchitectureMuñoz, Juan Pablo|||0000-0003-0912-4168Basei, Fernanda Luisa|||0000-0001-6232-7170Rojas, Maria Laura|||0000-0001-9849-7163Galvis, DavidZorzano Olarte, Antonio|||0000-0002-1638-0306LipidsMembrane contact sites (MCSs)Metabolic diseaseMetabolismMitochondriaMitochondrial dynamicsPharmacologyPost-translational modificationTethersMitochondrial network architecture plays a critical role in cellular physiology. Indeed, alterations in the shape of mitochondria upon exposure to cellular stress can cause the dysfunction of these organelles. In this scenario, mitochondrial dynamics proteins and the phospholipid composition of the mitochondrial membrane are key for fine-tuning the modulation of mitochondrial architecture. In addition, several factors including post-translational modifications such as the phosphorylation, acetylation, SUMOylation, and o-GlcNAcylation of mitochondrial dynamics proteins contribute to shaping the plasticity of this architecture. In this regard, several studies have evidenced that, upon metabolic stress, mitochondrial dynamics proteins are post-translationally modified, leading to the alteration of mitochondrial architecture. Interestingly, several proteins that sustain the mitochondrial lipid composition also modulate mitochondrial morphology and organelle communication. In this context, pharmacological studies have revealed that the modulation of mitochondrial shape and function emerges as a potential therapeutic strategy for metabolic diseases. Here, we review the factors that modulate mitochondrial architecture.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/303850https://dx.doi.org/urn:doi:10.3390/biom13081225reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-106209RB-I00Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1015open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3038502026-06-06T12:50:31Z
dc.title.none.fl_str_mv Mechanisms of Modulation of Mitochondrial Architecture
title Mechanisms of Modulation of Mitochondrial Architecture
spellingShingle Mechanisms of Modulation of Mitochondrial Architecture
Muñoz, Juan Pablo|||0000-0003-0912-4168
Lipids
Membrane contact sites (MCSs)
Metabolic disease
Metabolism
Mitochondria
Mitochondrial dynamics
Pharmacology
Post-translational modification
Tethers
title_short Mechanisms of Modulation of Mitochondrial Architecture
title_full Mechanisms of Modulation of Mitochondrial Architecture
title_fullStr Mechanisms of Modulation of Mitochondrial Architecture
title_full_unstemmed Mechanisms of Modulation of Mitochondrial Architecture
title_sort Mechanisms of Modulation of Mitochondrial Architecture
dc.creator.none.fl_str_mv Muñoz, Juan Pablo|||0000-0003-0912-4168
Basei, Fernanda Luisa|||0000-0001-6232-7170
Rojas, Maria Laura|||0000-0001-9849-7163
Galvis, David
Zorzano Olarte, Antonio|||0000-0002-1638-0306
author Muñoz, Juan Pablo|||0000-0003-0912-4168
author_facet Muñoz, Juan Pablo|||0000-0003-0912-4168
Basei, Fernanda Luisa|||0000-0001-6232-7170
Rojas, Maria Laura|||0000-0001-9849-7163
Galvis, David
Zorzano Olarte, Antonio|||0000-0002-1638-0306
author_role author
author2 Basei, Fernanda Luisa|||0000-0001-6232-7170
Rojas, Maria Laura|||0000-0001-9849-7163
Galvis, David
Zorzano Olarte, Antonio|||0000-0002-1638-0306
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Lipids
Membrane contact sites (MCSs)
Metabolic disease
Metabolism
Mitochondria
Mitochondrial dynamics
Pharmacology
Post-translational modification
Tethers
topic Lipids
Membrane contact sites (MCSs)
Metabolic disease
Metabolism
Mitochondria
Mitochondrial dynamics
Pharmacology
Post-translational modification
Tethers
description Mitochondrial network architecture plays a critical role in cellular physiology. Indeed, alterations in the shape of mitochondria upon exposure to cellular stress can cause the dysfunction of these organelles. In this scenario, mitochondrial dynamics proteins and the phospholipid composition of the mitochondrial membrane are key for fine-tuning the modulation of mitochondrial architecture. In addition, several factors including post-translational modifications such as the phosphorylation, acetylation, SUMOylation, and o-GlcNAcylation of mitochondrial dynamics proteins contribute to shaping the plasticity of this architecture. In this regard, several studies have evidenced that, upon metabolic stress, mitochondrial dynamics proteins are post-translationally modified, leading to the alteration of mitochondrial architecture. Interestingly, several proteins that sustain the mitochondrial lipid composition also modulate mitochondrial morphology and organelle communication. In this context, pharmacological studies have revealed that the modulation of mitochondrial shape and function emerges as a potential therapeutic strategy for metabolic diseases. Here, we review the factors that modulate mitochondrial architecture.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/303850
https://dx.doi.org/urn:doi:10.3390/biom13081225
url https://ddd.uab.cat/record/303850
https://dx.doi.org/urn:doi:10.3390/biom13081225
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-106209RB-I00
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1015
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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