Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction

Patients with severe mitral regurgitation (MR) after myocardial infarction (MI) have an increased risk of mortality. Transcatheter mitral valve repair may therefore be a suitable therapy. However, data on clinical outcomes of patients in an acute setting are scarce, especially those with reduced lef...

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Autores: Haberman, Dan|||0000-0003-2897-8919, Estevez-Loureiro, Rodrigo|||0000-0001-5841-5514, Benito-González, Tomás|||0000-0002-8428-9248, Denti, Paolo|||0000-0002-3075-0203, Arzamendi, Dabit|||0000-0001-7543-5867, Adamo, Marianna|||0000-0002-3855-1815, Freixa, Xavier|||0000-0002-3203-9060, Nombela-Franco, Luís|||0000-0003-3438-8907, Villablanca, Pedro, Krivoshei, Lian, Fam, Neil, Spargias, Konstantinos, Czarnecki, Andrew, Pascual, Isaac|||0000-0001-5433-1364, Praz, Fabien|||0000-0001-5416-165X, Sudarsky, Doron, Kerner, Arthur, Ninios, Vlasis, Gennari, Marco, Beeri, Ronen|||0000-0002-8014-0702, Perl, Leor|||0000-0002-0625-7937, Danenberg, Haim, Poles, Lion, Shimoni, Sara, Goland, Sorel, Caneiro-Queija, Berenice, Scianna, Salvatore, Moaraf, Igal, Schiavi, Davide|||0000-0002-3081-1678, Scardino, Claudia, Corpataux, Noé|||0000-0001-9514-6835, Echarte-Morales, Julio, Chrissoheris, Michael, Fernández-Peregrina, Estefanía|||0000-0002-3025-8251, Di Pasquale, Mattia, Regueiro, Ander|||0000-0001-5201-447X, Vergara-Uzcategui, Carlos|||0000-0001-7855-9128, Íñiguez-Romo, Andrés|||0000-0002-7758-6252, Fernández-Vázquez, Felipe|||0000-0001-7187-1290, Dvir, Danny, Taramasso, Maurizio|||0000-0001-7295-1153, Shuvy, Mony
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:271977
Acesso em linha:https://ddd.uab.cat/record/271977
https://dx.doi.org/urn:doi:10.3390/jcm10091819
Access Level:acceso abierto
Palavra-chave:Mitral regurgitation
Percutaneous mitral valve repair
Acute myocardial infarction
Left ventricle dysfunction
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spelling Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunctionHaberman, Dan|||0000-0003-2897-8919Estevez-Loureiro, Rodrigo|||0000-0001-5841-5514Benito-González, Tomás|||0000-0002-8428-9248Denti, Paolo|||0000-0002-3075-0203Arzamendi, Dabit|||0000-0001-7543-5867Adamo, Marianna|||0000-0002-3855-1815Freixa, Xavier|||0000-0002-3203-9060Nombela-Franco, Luís|||0000-0003-3438-8907Villablanca, PedroKrivoshei, LianFam, NeilSpargias, KonstantinosCzarnecki, AndrewPascual, Isaac|||0000-0001-5433-1364Praz, Fabien|||0000-0001-5416-165XSudarsky, DoronKerner, ArthurNinios, VlasisGennari, MarcoBeeri, Ronen|||0000-0002-8014-0702Perl, Leor|||0000-0002-0625-7937Danenberg, HaimPoles, LionShimoni, SaraGoland, SorelCaneiro-Queija, BereniceScianna, SalvatoreMoaraf, IgalSchiavi, Davide|||0000-0002-3081-1678Scardino, ClaudiaCorpataux, Noé|||0000-0001-9514-6835Echarte-Morales, JulioChrissoheris, MichaelFernández-Peregrina, Estefanía|||0000-0002-3025-8251Di Pasquale, MattiaRegueiro, Ander|||0000-0001-5201-447XVergara-Uzcategui, Carlos|||0000-0001-7855-9128Íñiguez-Romo, Andrés|||0000-0002-7758-6252Fernández-Vázquez, Felipe|||0000-0001-7187-1290Dvir, DannyTaramasso, Maurizio|||0000-0001-7295-1153Shuvy, MonyMitral regurgitationPercutaneous mitral valve repairAcute myocardial infarctionLeft ventricle dysfunctionPatients with severe mitral regurgitation (MR) after myocardial infarction (MI) have an increased risk of mortality. Transcatheter mitral valve repair may therefore be a suitable therapy. However, data on clinical outcomes of patients in an acute setting are scarce, especially those with reduced left ventricle (LV) dysfunction. We conducted a multinational, collaborative data analysis from 21 centers for patients who were, within 90 days of acute MI, treated with MitraClip due to severe MR. The cohort was divided according to median left ventricle ejection fraction (LVEF)-35%. Included in the study were 105 patients. The mean age was 71 ± 10 years. Patients in the LVEF < 35% group were younger but with comparable Euroscore II, multivessel coronary artery disease, prior MI and coronary artery bypass graft surgery. Procedure time was comparable and acute success rate was high in both groups (94% vs. 90%, p = 0.728). MR grade was significantly reduced in both groups along with an immediate reduction in left atrial V-wave, pulmonary artery pressure and improvement in New York Heart Association (NYHA) class. In-hospital and 1-year mortality rates were not significantly different between the two groups (11% vs. 7%, p = 0.51 and 19% vs. 12%, p = 0.49) and neither was the 3-month re-hospitalization rate. In conclusion, MitraClip intervention in patients with acute severe functional mitral regurgitation (FMR) due to a recent MI in an acute setting is safe and feasible. Even patients with severe LV dysfunction may benefit from transcatheter mitral valve intervention and should not be excluded. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/271977https://dx.doi.org/urn:doi:10.3390/jcm10091819reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2719772026-06-06T12:50:31Z
dc.title.none.fl_str_mv Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction
title Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction
spellingShingle Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction
Haberman, Dan|||0000-0003-2897-8919
Mitral regurgitation
Percutaneous mitral valve repair
Acute myocardial infarction
Left ventricle dysfunction
title_short Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction
title_full Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction
title_fullStr Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction
title_full_unstemmed Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction
title_sort Safety and feasibility of mitraclip implantation in patients with acute mitral regurgitation after recent myocardial infarction and severe left ventricle dysfunction
dc.creator.none.fl_str_mv Haberman, Dan|||0000-0003-2897-8919
Estevez-Loureiro, Rodrigo|||0000-0001-5841-5514
Benito-González, Tomás|||0000-0002-8428-9248
Denti, Paolo|||0000-0002-3075-0203
Arzamendi, Dabit|||0000-0001-7543-5867
Adamo, Marianna|||0000-0002-3855-1815
Freixa, Xavier|||0000-0002-3203-9060
Nombela-Franco, Luís|||0000-0003-3438-8907
Villablanca, Pedro
Krivoshei, Lian
Fam, Neil
Spargias, Konstantinos
Czarnecki, Andrew
Pascual, Isaac|||0000-0001-5433-1364
Praz, Fabien|||0000-0001-5416-165X
Sudarsky, Doron
Kerner, Arthur
Ninios, Vlasis
Gennari, Marco
Beeri, Ronen|||0000-0002-8014-0702
Perl, Leor|||0000-0002-0625-7937
Danenberg, Haim
Poles, Lion
Shimoni, Sara
Goland, Sorel
Caneiro-Queija, Berenice
Scianna, Salvatore
Moaraf, Igal
Schiavi, Davide|||0000-0002-3081-1678
Scardino, Claudia
Corpataux, Noé|||0000-0001-9514-6835
Echarte-Morales, Julio
Chrissoheris, Michael
Fernández-Peregrina, Estefanía|||0000-0002-3025-8251
Di Pasquale, Mattia
Regueiro, Ander|||0000-0001-5201-447X
Vergara-Uzcategui, Carlos|||0000-0001-7855-9128
Íñiguez-Romo, Andrés|||0000-0002-7758-6252
Fernández-Vázquez, Felipe|||0000-0001-7187-1290
Dvir, Danny
Taramasso, Maurizio|||0000-0001-7295-1153
Shuvy, Mony
author Haberman, Dan|||0000-0003-2897-8919
author_facet Haberman, Dan|||0000-0003-2897-8919
Estevez-Loureiro, Rodrigo|||0000-0001-5841-5514
Benito-González, Tomás|||0000-0002-8428-9248
Denti, Paolo|||0000-0002-3075-0203
Arzamendi, Dabit|||0000-0001-7543-5867
Adamo, Marianna|||0000-0002-3855-1815
Freixa, Xavier|||0000-0002-3203-9060
Nombela-Franco, Luís|||0000-0003-3438-8907
Villablanca, Pedro
Krivoshei, Lian
Fam, Neil
Spargias, Konstantinos
Czarnecki, Andrew
Pascual, Isaac|||0000-0001-5433-1364
Praz, Fabien|||0000-0001-5416-165X
Sudarsky, Doron
Kerner, Arthur
Ninios, Vlasis
Gennari, Marco
Beeri, Ronen|||0000-0002-8014-0702
Perl, Leor|||0000-0002-0625-7937
Danenberg, Haim
Poles, Lion
Shimoni, Sara
Goland, Sorel
Caneiro-Queija, Berenice
Scianna, Salvatore
Moaraf, Igal
Schiavi, Davide|||0000-0002-3081-1678
Scardino, Claudia
Corpataux, Noé|||0000-0001-9514-6835
Echarte-Morales, Julio
Chrissoheris, Michael
Fernández-Peregrina, Estefanía|||0000-0002-3025-8251
Di Pasquale, Mattia
Regueiro, Ander|||0000-0001-5201-447X
Vergara-Uzcategui, Carlos|||0000-0001-7855-9128
Íñiguez-Romo, Andrés|||0000-0002-7758-6252
Fernández-Vázquez, Felipe|||0000-0001-7187-1290
Dvir, Danny
Taramasso, Maurizio|||0000-0001-7295-1153
Shuvy, Mony
author_role author
author2 Estevez-Loureiro, Rodrigo|||0000-0001-5841-5514
Benito-González, Tomás|||0000-0002-8428-9248
Denti, Paolo|||0000-0002-3075-0203
Arzamendi, Dabit|||0000-0001-7543-5867
Adamo, Marianna|||0000-0002-3855-1815
Freixa, Xavier|||0000-0002-3203-9060
Nombela-Franco, Luís|||0000-0003-3438-8907
Villablanca, Pedro
Krivoshei, Lian
Fam, Neil
Spargias, Konstantinos
Czarnecki, Andrew
Pascual, Isaac|||0000-0001-5433-1364
Praz, Fabien|||0000-0001-5416-165X
Sudarsky, Doron
Kerner, Arthur
Ninios, Vlasis
Gennari, Marco
Beeri, Ronen|||0000-0002-8014-0702
Perl, Leor|||0000-0002-0625-7937
Danenberg, Haim
Poles, Lion
Shimoni, Sara
Goland, Sorel
Caneiro-Queija, Berenice
Scianna, Salvatore
Moaraf, Igal
Schiavi, Davide|||0000-0002-3081-1678
Scardino, Claudia
Corpataux, Noé|||0000-0001-9514-6835
Echarte-Morales, Julio
Chrissoheris, Michael
Fernández-Peregrina, Estefanía|||0000-0002-3025-8251
Di Pasquale, Mattia
Regueiro, Ander|||0000-0001-5201-447X
Vergara-Uzcategui, Carlos|||0000-0001-7855-9128
Íñiguez-Romo, Andrés|||0000-0002-7758-6252
Fernández-Vázquez, Felipe|||0000-0001-7187-1290
Dvir, Danny
Taramasso, Maurizio|||0000-0001-7295-1153
Shuvy, Mony
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mitral regurgitation
Percutaneous mitral valve repair
Acute myocardial infarction
Left ventricle dysfunction
topic Mitral regurgitation
Percutaneous mitral valve repair
Acute myocardial infarction
Left ventricle dysfunction
description Patients with severe mitral regurgitation (MR) after myocardial infarction (MI) have an increased risk of mortality. Transcatheter mitral valve repair may therefore be a suitable therapy. However, data on clinical outcomes of patients in an acute setting are scarce, especially those with reduced left ventricle (LV) dysfunction. We conducted a multinational, collaborative data analysis from 21 centers for patients who were, within 90 days of acute MI, treated with MitraClip due to severe MR. The cohort was divided according to median left ventricle ejection fraction (LVEF)-35%. Included in the study were 105 patients. The mean age was 71 ± 10 years. Patients in the LVEF < 35% group were younger but with comparable Euroscore II, multivessel coronary artery disease, prior MI and coronary artery bypass graft surgery. Procedure time was comparable and acute success rate was high in both groups (94% vs. 90%, p = 0.728). MR grade was significantly reduced in both groups along with an immediate reduction in left atrial V-wave, pulmonary artery pressure and improvement in New York Heart Association (NYHA) class. In-hospital and 1-year mortality rates were not significantly different between the two groups (11% vs. 7%, p = 0.51 and 19% vs. 12%, p = 0.49) and neither was the 3-month re-hospitalization rate. In conclusion, MitraClip intervention in patients with acute severe functional mitral regurgitation (FMR) due to a recent MI in an acute setting is safe and feasible. Even patients with severe LV dysfunction may benefit from transcatheter mitral valve intervention and should not be excluded.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/271977
https://dx.doi.org/urn:doi:10.3390/jcm10091819
url https://ddd.uab.cat/record/271977
https://dx.doi.org/urn:doi:10.3390/jcm10091819
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
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eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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