Multiplexed nanotracers for biomedical imaging and therapy of glioblastoma
Since the end of the 20th century, nanotechnology has revolutionized the field of medicine. Specifically, iron oxide nanoparticles, owing to their versatility and special properties at the nanoscale, continue to be promising tools for the development of new solutions in biomedicine. In this PhD thes...
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| Format: | doctoral thesis |
| Publication Date: | 2025 |
| Country: | España |
| Institution: | Universidad Complutense de Madrid (UCM) |
| Repository: | Docta Complutense |
| Language: | English |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/119163 |
| Online Access: | https://hdl.handle.net/20.500.14352/119163 |
| Access Level: | Open access |
| Keyword: | 62-181.48(043.2) Nanotecnología Farmacia 3209 Farmacología |
| Summary: | Since the end of the 20th century, nanotechnology has revolutionized the field of medicine. Specifically, iron oxide nanoparticles, owing to their versatility and special properties at the nanoscale, continue to be promising tools for the development of new solutions in biomedicine. In this PhD thesis, the modification of these nanosystems has been explored to enable their possible use as positive contrast agents in magnetic resonance imaging and for new approaches in both imaging and therapy with ionizing radiation. The development of a new T1 contrast agent has been carried out by selecting and improving the synthesis methodology and choosing composition modulation over other modifications of nanoparticles. The enhanced in vivo behavior of this new contrast agent was demonstrated in comparison with Gadovist®, resulting in better images at longer times with lower contrast agent concentrations than those commonly used with gadolinium compounds... |
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