Similarities and differences between systemic juvenile idiopathic arthritis and adult-onset Still's disease: a multicenter Spanish study

To describe the characteristics of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD), compare their presentation and evolution, and analyse possible complication predictors. Multicenter study. Data were retrieved from a hospital-based study of patients with a...

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Autores: Antón López, Jordi, Mosquera Anguita, Juan Manuel, Calzada Hernández, Joan, Iglesias Jiménez, Estíbaliz, Zacarías, Andrea, Olivé, Alejandro, Bittermann, Violeta, Rodríguez Lorenzo, Tania, Remesal, Agustín, Quintana-Ortega, Cristian, Nuño-Nuño, Laura, Robles Marhuenda, Ángel, De Inocencio, Jaime, Martín-López, María, Carreira, Patricia E., Brandy-García, Anahy M., Holgado, Susana, Camacho Lovillo, Marisol, Ruiz-Román, Alberto, Clemente, Daniel, Narváez García, Francisco Javier, Campos, José, Sánchez Manubens, Judith, Bernabeu, Pilar, Graña Gil, Jenaro, Vargas Lebrón, Carmen, Ortiz-Santamaria, Vera, Castañeda, Sergio, García de Yébenes, M.J., Carmona, L.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/219511
Acceso en línea:https://hdl.handle.net/2445/219511
Access Level:acceso abierto
Palabra clave:Artritis
Inflamació
Epidemiologia
Arthritis
Inflammation
Epidemiology
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spelling Similarities and differences between systemic juvenile idiopathic arthritis and adult-onset Still's disease: a multicenter Spanish studyAntón López, JordiMosquera Anguita, Juan ManuelCalzada Hernández, JoanIglesias Jiménez, EstíbalizZacarías, AndreaOlivé, AlejandroBittermann, VioletaRodríguez Lorenzo, TaniaRemesal, AgustínQuintana-Ortega, CristianNuño-Nuño, LauraRobles Marhuenda, ÁngelDe Inocencio, JaimeMartín-López, MaríaCarreira, Patricia E.Brandy-García, Anahy M.Holgado, SusanaCamacho Lovillo, MarisolRuiz-Román, AlbertoClemente, DanielNarváez García, Francisco JavierCampos, JoséSánchez Manubens, JudithBernabeu, PilarGraña Gil, JenaroVargas Lebrón, CarmenOrtiz-Santamaria, VeraCastañeda, SergioGarcía de Yébenes, M.J.Carmona, L.ArtritisInflamacióEpidemiologiaArthritisInflammationEpidemiologyTo describe the characteristics of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD), compare their presentation and evolution, and analyse possible complication predictors. Multicenter study. Data were retrieved from a hospital-based study of patients with a diagnosis or suspected diagnosis of sJIA or AOSD according to the responsible physician and followed-up for at least one year. Descriptive variables (classification criteria, clinical manifestations, complications, family, and personal history) were collected at disease onset and during follow-up. We present the clinical characteristics of 326 patients, 67% of whom had a diagnosis of sJIA and 33% of AOSD. Clinical manifestation frequencies were similar between the two groups, except for odynophagia, which was significantly more frequent in AOSD than in sJIA (78.4% vs. 25.5%; p < 0.0001). Among the complications, macrophage activation syndrome (MAS) was significantly more common in sJIA than in AOSD (24.4% vs. 9.5%; p = 0.002), to the extent that an sJIA diagnosis significantly increased the risk of MAS, together with serositis presence, and the need for biological therapy. Patients with sJIA and AOSD showed similar characteristics, supporting the idea that they are both part of Still's disease, but are expressed at different ages. Differences in manifestations and complications might be due to different management between diseases and immune response maturity.Springer Verlag2025202520242025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/219511Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1007/s00296-024-05658-6Rheumatology International, 2024, vol. 44, num.12, p. 2911-2920https://doi.org/10.1007/s00296-024-05658-6cc by (c) Antón López, Jordi et al., 2024https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2195112026-05-29T05:05:01Z
dc.title.none.fl_str_mv Similarities and differences between systemic juvenile idiopathic arthritis and adult-onset Still's disease: a multicenter Spanish study
title Similarities and differences between systemic juvenile idiopathic arthritis and adult-onset Still's disease: a multicenter Spanish study
spellingShingle Similarities and differences between systemic juvenile idiopathic arthritis and adult-onset Still's disease: a multicenter Spanish study
Antón López, Jordi
Artritis
Inflamació
Epidemiologia
Arthritis
Inflammation
Epidemiology
title_short Similarities and differences between systemic juvenile idiopathic arthritis and adult-onset Still's disease: a multicenter Spanish study
title_full Similarities and differences between systemic juvenile idiopathic arthritis and adult-onset Still's disease: a multicenter Spanish study
title_fullStr Similarities and differences between systemic juvenile idiopathic arthritis and adult-onset Still's disease: a multicenter Spanish study
title_full_unstemmed Similarities and differences between systemic juvenile idiopathic arthritis and adult-onset Still's disease: a multicenter Spanish study
title_sort Similarities and differences between systemic juvenile idiopathic arthritis and adult-onset Still's disease: a multicenter Spanish study
dc.creator.none.fl_str_mv Antón López, Jordi
Mosquera Anguita, Juan Manuel
Calzada Hernández, Joan
Iglesias Jiménez, Estíbaliz
Zacarías, Andrea
Olivé, Alejandro
Bittermann, Violeta
Rodríguez Lorenzo, Tania
Remesal, Agustín
Quintana-Ortega, Cristian
Nuño-Nuño, Laura
Robles Marhuenda, Ángel
De Inocencio, Jaime
Martín-López, María
Carreira, Patricia E.
Brandy-García, Anahy M.
Holgado, Susana
Camacho Lovillo, Marisol
Ruiz-Román, Alberto
Clemente, Daniel
Narváez García, Francisco Javier
Campos, José
Sánchez Manubens, Judith
Bernabeu, Pilar
Graña Gil, Jenaro
Vargas Lebrón, Carmen
Ortiz-Santamaria, Vera
Castañeda, Sergio
García de Yébenes, M.J.
Carmona, L.
author Antón López, Jordi
author_facet Antón López, Jordi
Mosquera Anguita, Juan Manuel
Calzada Hernández, Joan
Iglesias Jiménez, Estíbaliz
Zacarías, Andrea
Olivé, Alejandro
Bittermann, Violeta
Rodríguez Lorenzo, Tania
Remesal, Agustín
Quintana-Ortega, Cristian
Nuño-Nuño, Laura
Robles Marhuenda, Ángel
De Inocencio, Jaime
Martín-López, María
Carreira, Patricia E.
Brandy-García, Anahy M.
Holgado, Susana
Camacho Lovillo, Marisol
Ruiz-Román, Alberto
Clemente, Daniel
Narváez García, Francisco Javier
Campos, José
Sánchez Manubens, Judith
Bernabeu, Pilar
Graña Gil, Jenaro
Vargas Lebrón, Carmen
Ortiz-Santamaria, Vera
Castañeda, Sergio
García de Yébenes, M.J.
Carmona, L.
author_role author
author2 Mosquera Anguita, Juan Manuel
Calzada Hernández, Joan
Iglesias Jiménez, Estíbaliz
Zacarías, Andrea
Olivé, Alejandro
Bittermann, Violeta
Rodríguez Lorenzo, Tania
Remesal, Agustín
Quintana-Ortega, Cristian
Nuño-Nuño, Laura
Robles Marhuenda, Ángel
De Inocencio, Jaime
Martín-López, María
Carreira, Patricia E.
Brandy-García, Anahy M.
Holgado, Susana
Camacho Lovillo, Marisol
Ruiz-Román, Alberto
Clemente, Daniel
Narváez García, Francisco Javier
Campos, José
Sánchez Manubens, Judith
Bernabeu, Pilar
Graña Gil, Jenaro
Vargas Lebrón, Carmen
Ortiz-Santamaria, Vera
Castañeda, Sergio
García de Yébenes, M.J.
Carmona, L.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Artritis
Inflamació
Epidemiologia
Arthritis
Inflammation
Epidemiology
topic Artritis
Inflamació
Epidemiologia
Arthritis
Inflammation
Epidemiology
description To describe the characteristics of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still's disease (AOSD), compare their presentation and evolution, and analyse possible complication predictors. Multicenter study. Data were retrieved from a hospital-based study of patients with a diagnosis or suspected diagnosis of sJIA or AOSD according to the responsible physician and followed-up for at least one year. Descriptive variables (classification criteria, clinical manifestations, complications, family, and personal history) were collected at disease onset and during follow-up. We present the clinical characteristics of 326 patients, 67% of whom had a diagnosis of sJIA and 33% of AOSD. Clinical manifestation frequencies were similar between the two groups, except for odynophagia, which was significantly more frequent in AOSD than in sJIA (78.4% vs. 25.5%; p < 0.0001). Among the complications, macrophage activation syndrome (MAS) was significantly more common in sJIA than in AOSD (24.4% vs. 9.5%; p = 0.002), to the extent that an sJIA diagnosis significantly increased the risk of MAS, together with serositis presence, and the need for biological therapy. Patients with sJIA and AOSD showed similar characteristics, supporting the idea that they are both part of Still's disease, but are expressed at different ages. Differences in manifestations and complications might be due to different management between diseases and immune response maturity.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/219511
url https://hdl.handle.net/2445/219511
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1007/s00296-024-05658-6
Rheumatology International, 2024, vol. 44, num.12, p. 2911-2920
https://doi.org/10.1007/s00296-024-05658-6
dc.rights.none.fl_str_mv cc by (c) Antón López, Jordi et al., 2024
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Antón López, Jordi et al., 2024
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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