Anxiolytic-like effects of Lupinus angustifolious protein hydrolysates in alzheimer model mice
Alzheimer’s disease (AD), which is characterized by a devastating and progressive loss of memory, is the principal neurodegenerative disease in the elderly population worldwide. As a consequence, AD patients present neuropsychiatric symptoms, such as anxiety, causing sleeping difficulty, irritabilit...
| Autores: | , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universidad de Sevilla (US) |
| Repositorio: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/150995 |
| Acceso en línea: | https://hdl.handle.net/11441/150995 https://doi.org/10.3390/foods_2020-07685 |
| Access Level: | acceso abierto |
| Palabra clave: | Alzheimer's Anxiety Lupine protein hydrolysates ApoE−/− Functional food ingredient |
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Anxiolytic-like effects of Lupinus angustifolious protein hydrolysates in alzheimer model miceSantos Sánchez, GuillermoPonce España, EduardoCruz Chamorro, IvánLópez García, Juan CarlosÁlvarez López, Ana IsabelPedroche, JustoMillán-Linares, María del CarmenMillán, FranciscoLardone, Patricia JudithBejarano Hernando, IgnacioGuerrero Montávez, Juan MiguelCarrillo Vico, AntonioAlzheimer'sAnxietyLupine protein hydrolysatesApoE−/−Functional food ingredientAlzheimer’s disease (AD), which is characterized by a devastating and progressive loss of memory, is the principal neurodegenerative disease in the elderly population worldwide. As a consequence, AD patients present neuropsychiatric symptoms, such as anxiety, causing sleeping difficulty, irritability, agitation, or aggressiveness. Previous studies have demonstrated that a high-fat diet, in addition to exacerbating AD, aggravates anxiety. We have demonstrated that Lupinus angustifolius protein hydrolysates (LPHs) have anti-inflammatory and antioxidant effects, key factors for AD and anxiety. Thus, this study aimed to evaluate the potential effects of LPHs on spatial memory and anxiety of a preclinical model of AD. ApoE−/− mice fed with a western diet were intragastrically treated with LPHs (or a vehicle) for 14 weeks. Spatial memory and anxiety were then assessed through the Morris water maze and elevated plus maze, respectively. The results did not show significant differences in spatial memory between groups. However, a significant increase (p < 0.05) in time in open arms, center time, the number of crossings, and a reduction of anxiety behavior were observed in LPH-treated mice. This is the first study showing that an LPH treatment causes anxiolytic effects, pointing to LPHs as a potential component of future nutritional therapies.Ministerio de Economía y Competitividad AGL2012-40247-C02-01Ministerio de Economía y Competitividad AGL2012-40247-C02-02Ministerio de Salud del Gobierno Andaluz PC-0111-2016-0111Gobierno Andaluz CTS160Ministerio de Educación, Cultura y Deporte FPU16/02339Ministerio de Educación, Cultura y Deporte FPU13/01210Universidad de Sevilla VI PPIT-USMDPIPsicología ExperimentalBioquímica Médica y Biología Molecular e InmunologíaMinisterio de Economía y Competitividad (MINECO). EspañaMinisterio de Salud del Gobierno AndaluzGobierno AndaluzMinisterio de Educación, Cultura y Deporte (MECD). EspañaUniversidad de Sevilla2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/150995https://doi.org/10.3390/foods_2020-07685reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésProceedings, 70 (1), 41, 1-6.AGL2012-40247-C02-01AGL2012-40247-C02-02PC-0111-2016-0111CTS160FPU16/02339FPU13/01210VI PPIT-UShttps://www.mdpi.com/2504-3900/70/1/41info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1509952026-06-17T12:51:07Z |
| dc.title.none.fl_str_mv |
Anxiolytic-like effects of Lupinus angustifolious protein hydrolysates in alzheimer model mice |
| title |
Anxiolytic-like effects of Lupinus angustifolious protein hydrolysates in alzheimer model mice |
| spellingShingle |
Anxiolytic-like effects of Lupinus angustifolious protein hydrolysates in alzheimer model mice Santos Sánchez, Guillermo Alzheimer's Anxiety Lupine protein hydrolysates ApoE−/− Functional food ingredient |
| title_short |
Anxiolytic-like effects of Lupinus angustifolious protein hydrolysates in alzheimer model mice |
| title_full |
Anxiolytic-like effects of Lupinus angustifolious protein hydrolysates in alzheimer model mice |
| title_fullStr |
Anxiolytic-like effects of Lupinus angustifolious protein hydrolysates in alzheimer model mice |
| title_full_unstemmed |
Anxiolytic-like effects of Lupinus angustifolious protein hydrolysates in alzheimer model mice |
| title_sort |
Anxiolytic-like effects of Lupinus angustifolious protein hydrolysates in alzheimer model mice |
| dc.creator.none.fl_str_mv |
Santos Sánchez, Guillermo Ponce España, Eduardo Cruz Chamorro, Iván López García, Juan Carlos Álvarez López, Ana Isabel Pedroche, Justo Millán-Linares, María del Carmen Millán, Francisco Lardone, Patricia Judith Bejarano Hernando, Ignacio Guerrero Montávez, Juan Miguel Carrillo Vico, Antonio |
| author |
Santos Sánchez, Guillermo |
| author_facet |
Santos Sánchez, Guillermo Ponce España, Eduardo Cruz Chamorro, Iván López García, Juan Carlos Álvarez López, Ana Isabel Pedroche, Justo Millán-Linares, María del Carmen Millán, Francisco Lardone, Patricia Judith Bejarano Hernando, Ignacio Guerrero Montávez, Juan Miguel Carrillo Vico, Antonio |
| author_role |
author |
| author2 |
Ponce España, Eduardo Cruz Chamorro, Iván López García, Juan Carlos Álvarez López, Ana Isabel Pedroche, Justo Millán-Linares, María del Carmen Millán, Francisco Lardone, Patricia Judith Bejarano Hernando, Ignacio Guerrero Montávez, Juan Miguel Carrillo Vico, Antonio |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Psicología Experimental Bioquímica Médica y Biología Molecular e Inmunología Ministerio de Economía y Competitividad (MINECO). España Ministerio de Salud del Gobierno Andaluz Gobierno Andaluz Ministerio de Educación, Cultura y Deporte (MECD). España Universidad de Sevilla |
| dc.subject.none.fl_str_mv |
Alzheimer's Anxiety Lupine protein hydrolysates ApoE−/− Functional food ingredient |
| topic |
Alzheimer's Anxiety Lupine protein hydrolysates ApoE−/− Functional food ingredient |
| description |
Alzheimer’s disease (AD), which is characterized by a devastating and progressive loss of memory, is the principal neurodegenerative disease in the elderly population worldwide. As a consequence, AD patients present neuropsychiatric symptoms, such as anxiety, causing sleeping difficulty, irritability, agitation, or aggressiveness. Previous studies have demonstrated that a high-fat diet, in addition to exacerbating AD, aggravates anxiety. We have demonstrated that Lupinus angustifolius protein hydrolysates (LPHs) have anti-inflammatory and antioxidant effects, key factors for AD and anxiety. Thus, this study aimed to evaluate the potential effects of LPHs on spatial memory and anxiety of a preclinical model of AD. ApoE−/− mice fed with a western diet were intragastrically treated with LPHs (or a vehicle) for 14 weeks. Spatial memory and anxiety were then assessed through the Morris water maze and elevated plus maze, respectively. The results did not show significant differences in spatial memory between groups. However, a significant increase (p < 0.05) in time in open arms, center time, the number of crossings, and a reduction of anxiety behavior were observed in LPH-treated mice. This is the first study showing that an LPH treatment causes anxiolytic effects, pointing to LPHs as a potential component of future nutritional therapies. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/11441/150995 https://doi.org/10.3390/foods_2020-07685 |
| url |
https://hdl.handle.net/11441/150995 https://doi.org/10.3390/foods_2020-07685 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Proceedings, 70 (1), 41, 1-6. AGL2012-40247-C02-01 AGL2012-40247-C02-02 PC-0111-2016-0111 CTS160 FPU16/02339 FPU13/01210 VI PPIT-US https://www.mdpi.com/2504-3900/70/1/41 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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MDPI |
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MDPI |
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